Product image of Levofloxacine Pch (Levofloxacin Hemihydrate) supplied by GNH India

Levofloxacine Pch

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Levofloxacine Pch (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Levofloxacine Pch, is a fluoroquinolone antibiotic presented as an oral dosage form for systemic use. It is employed to treat a broad spectrum of bacterial infections in adults, such as community‑acquired respiratory tract infections, urinary tract infections, skin and soft‑tissue infections, and complicated intra‑abdominal infections.

GNH India supplies Levofloxacine Pch as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and providing reliable global distribution.

Manufacturer / TM Owner

Pharmachemie Bv

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Indications & Clinical Uses

Levofloxacin is used to manage bacterial infections affecting several organ systems.

  • Community‑acquired pneumonia: effective in eradicating the causative pathogens and improving respiratory symptoms.
  • Acute exacerbations of chronic bronchitis: reduces bacterial load and shortens the duration of the exacerbation.
  • Uncomplicated urinary tract infection: clears the infection and relieves dysuria and frequency.
  • Skin and soft‑tissue infection: resolves cellulitis, abscesses, and wound infections caused by susceptible organisms.
  • Acute bacterial prostatitis: eliminates the infection within the prostate and alleviates associated pain.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription and repair. By stabilizing the enzyme‑DNA complex, it prevents the resealing of DNA strands, leading to accumulation of double‑strand breaks and bacterial cell death. This bactericidal activity is concentration‑dependent and covers a wide range of Gram‑negative and Gram‑positive organisms.

Side Effects

Levofloxacine Pch may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects

  • Nausea: mild stomach upset.
  • Diarrhea: loose stools.
  • Headache: transient cranial discomfort.
  • Rash: mild skin erythema or itching.

Serious or Rare Side Effects

  • Tendon rupture: sudden pain and loss of function, especially in the Achilles tendon.
  • QT interval prolongation: cardiac rhythm disturbances that may lead to arrhythmia.
  • Severe hypersensitivity: anaphylaxis, angioedema, or Stevens‑Johnson syndrome.

Precautions & Warnings

When prescribing Levofloxacine Pch, clinicians should consider several safety aspects.

  • Renal function: adjust use in patients with impaired renal clearance and monitor serum creatinine.
  • Age: use cautiously in elderly patients due to increased risk of tendon injury.
  • Phototoxicity: advise patients to avoid excessive sunlight and use sunscreen.
  • CNS effects: monitor for seizures or confusion, especially in patients with a history of neurological disorders.
  • Drug resistance: limit use to infections confirmed or strongly suspected to be caused by susceptible bacteria.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original container.

Avoid Interactions

Levofloxacine Pch can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levofloxacin absorption; separate dosing by at least 2 hours.
  • Iron or zinc supplements: chelate the drug and markedly decrease bioavailability.
  • Warfarin: may enhance anticoagulant effect and increase INR; monitor coagulation parameters.

Moderate Interactions (Monitor Closely)

  • NSAIDs (e.g., ibuprofen): may increase risk of CNS stimulation and seizures.
  • Theophylline: levofloxacin can raise plasma theophylline levels, requiring dose adjustment.
  • Corticosteroids: combined use may increase risk of tendon rupture.

Frequently Asked Questions

Levofloxacine Pch contains levofloxacin, a fluoroquinolone that is indicated for a range of bacterial infections, including community‑acquired pneumonia, acute exacerbations of chronic bronchitis, uncomplicated urinary tract infections, skin and soft‑tissue infections, acute bacterial prostatitis, and complicated intra‑abdominal infections.

Levofloxacin blocks bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes required for DNA replication and transcription. By preventing the resealing of DNA strands, it causes lethal double‑strand breaks, leading to rapid bacterial cell death.

The dosage of Levofloxacine Pch is determined by the prescribing clinician based on the infection type, severity, patient age, renal function and other clinical factors. No fixed regimen is provided here; the prescriber will set the appropriate dose and schedule.

Safety data for levofloxacin in pregnancy and lactation are limited, and the drug is generally avoided unless the potential benefit outweighs the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare professional.

To request Levofloxacine Pch, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Levofloxacine Pch belongs to the fluoroquinolone class, offering broad‑spectrum activity against many Gram‑negative and Gram‑positive bacteria and a convenient once‑daily oral dosing for many infections. Compared with older agents such as ciprofloxacin, levofloxacin provides enhanced activity against Streptococcus pneumoniae and better pharmacokinetic profiles, but it shares class‑related safety considerations.

Levofloxacine Pch should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Levofloxacine Pch is taken orally, usually with a full glass of water. It may be taken with or without food, but if antacids, iron, zinc or calcium supplements are used, they should be spaced at least two hours apart to avoid reduced absorption.

Serious adverse events include tendon rupture (especially the Achilles tendon), QT‑interval prolongation that can lead to arrhythmias, and severe hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience sudden tendon pain, palpitations, or signs of a severe allergic reaction.

Levofloxacine Pch is contraindicated in individuals with a known hypersensitivity to levofloxacin or other fluoroquinolones. It should also be avoided in patients taking medications that significantly prolong the QT interval, those with a history of tendon disorders related to fluoroquinolone use, and, unless clearly justified, in pregnant or breastfeeding women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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