Product image of Levofloxacine Sandoz (Levofloxacin) supplied by GNH India

Levofloxacine Sandoz

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacine Sandoz (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacine Sandoz, is a fluoroquinolone antibiotic presented as an oral dosage form for oral use. It treats bacterial infections such as urinary tract infections, respiratory tract infections, skin and soft‑tissue infections, prostatitis and complicated intra‑abdominal infections in adult patients.

GNH India supplies Levofloxacine Sandoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz B.V.

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Indications & Clinical Uses

Levofloxacine Sandoz is a broad‑spectrum fluoroquinolone that targets bacterial pathogens in several organ systems.

  • Urinary tract infections: eradicates susceptible Gram‑negative and Gram‑positive bacteria, improving clinical cure rates.
  • Respiratory tract infections (e.g., community‑acquired pneumonia): provides rapid bacterial clearance and symptom resolution.
  • Skin and soft‑tissue infections: treats cellulitis, abscesses and other bacterial skin conditions.
  • Prostatitis: penetrates prostatic tissue to eliminate causative organisms.
  • Complicated intra‑abdominal infections: covers mixed aerobic and anaerobic flora for effective therapy.

How It Works

  • Levofloxacin exerts a bactericidal effect by selectively inhibiting bacterial DNA gyrase (topoisomerase II) and topoisomerase IV. This dual inhibition prevents DNA supercoiling and separation, thereby blocking DNA replication and transcription, leading to bacterial cell death.

Side Effects

Levofloxacine Sandoz may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Dizziness
  • Abdominal pain
  • Rash

Serious or Rare Side Effects

  • Tendon rupture or tendinitis
  • QT interval prolongation and cardiac arrhythmias
  • Peripheral neuropathy
  • Clostridioides difficile‑associated colitis
  • Severe allergic reactions (anaphylaxis)
  • Hepatic dysfunction or elevated liver enzymes

Precautions & Warnings

Use Levofloxacine Sandoz with caution and follow clinical guidelines.

  • Renal function: adjust dose in patients with impaired clearance.
  • Age: monitor elderly patients closely due to increased tendon injury risk.
  • Concomitant NSAIDs: avoid combined use to reduce tendon rupture risk.
  • Photosensitivity: advise patients to limit exposure to direct sunlight.
  • QT interval: obtain baseline ECG and monitor in patients with cardiac risk factors.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Levofloxacine Sandoz can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect; monitor INR closely.
  • Corticosteroids: heightened risk of tendon rupture.
  • NSAIDs: may amplify central nervous system stimulation.
  • Cyclosporine: potential increase in levofloxacin plasma levels.

Moderate Interactions (Monitor Closely)

  • Theophylline: may raise serum theophylline concentrations.
  • Insulin or sulfonylureas: risk of hypoglycemia.
  • Quinolone‑resistant bacterial strains: may diminish therapeutic efficacy.
  • Other fluoroquinolones: avoid concurrent use to prevent additive toxicity.
  • Methylprednisolone: monitor for tendon complications.

Frequently Asked Questions

Levofloxacine Sandoz is a fluoroquinolone antibiotic indicated for the treatment of adult bacterial infections such as urinary tract infections, community‑acquired pneumonia, skin and soft‑tissue infections, prostatitis and complicated intra‑abdominal infections.

Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. By blocking these targets, the drug prevents bacterial DNA synthesis, leading to rapid bactericidal activity against susceptible organisms.

The prescribed dose of Levofloxacine Sandoz is determined by the treating physician based on the type and severity of infection, patient age, renal function and other clinical factors. The prescriber will set the appropriate regimen.

Safety of levofloxacin in pregnancy and lactation has not been definitively established. It should be used only when the potential benefit justifies the potential risk to the fetus or infant, and only under the guidance of a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levofloxacin offers a broader spectrum of activity against Gram‑positive and Gram‑negative pathogens compared with older agents like ciprofloxacin, and it can be administered once daily for many infections, which may improve patient adherence while maintaining comparable efficacy.

Levofloxacine Sandoz should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keep the container tightly closed and out of reach of children.

The medication is taken orally, usually as a whole tablet swallowed with a full glass of water. It may be taken with or without food, but patients should follow the prescriber’s instructions regarding timing relative to meals.

Serious adverse events include tendon rupture or tendinitis, QT‑interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, peripheral neuropathy and Clostridioides difficile‑associated colitis. Patients should seek immediate medical attention if these occur.

Levofloxacine Sandoz is contraindicated in individuals with a known hypersensitivity to levofloxacin or other fluoroquinolones, those with a history of tendon disorders related to quinolone therapy, pregnant women unless essential, and children except for specific approved indications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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