Product image of Levofloxacine Teva (Levofloxacin Hemihydrate) supplied by GNH India

Levofloxacine Teva

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Levofloxacine Teva (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Levofloxacine Teva, is a fluoroquinolone antibiotic presented as an oral dosage form for oral use. It treats a range of bacterial infections in adults and adolescents when prescribed by a qualified health professional.

GNH India supplies Levofloxacine Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Santé

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Indications & Clinical Uses

Levofloxacine Teva is a fluoroquinolone antibiotic indicated for several bacterial infections.

  • Community‑acquired respiratory tract infection: eradicates susceptible pathogens and improves respiratory symptoms.
  • Acute bacterial sinusitis: reduces bacterial load and relieves sinus inflammation.
  • Acute exacerbations of chronic bronchitis: shortens disease course and prevents complications.
  • Uncomplicated urinary tract infection: clears infection and restores urinary function.
  • Skin and soft tissue infection: eliminates causative bacteria and promotes healing.
  • Prostatitis: treats bacterial prostatitis and alleviates associated pain.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By binding to these enzymes, it prevents the supercoiling and separation of DNA strands, leading to bacterial cell death. The drug exhibits concentration‑dependent bactericidal activity against a broad spectrum of Gram‑positive and Gram‑negative organisms.

Side Effects

Levofloxacine Teva may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Dizziness
  • Abdominal pain
  • Rash

Serious or Rare Side Effects

  • Tendon rupture or tendinitis
  • QT interval prolongation leading to arrhythmia
  • Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome)
  • Clostridioides difficile‑associated colitis
  • Hepatic toxicity
  • Peripheral neuropathy

Precautions & Warnings

Before prescribing Levofloxacine Teva, clinicians should consider several safety measures.

  • Renal function assessment: adjust dose in patients with impaired clearance.
  • Hypersensitivity check: avoid in individuals with known fluoroquinolone allergy.
  • Elderly caution: monitor for CNS effects and tendon disorders.
  • Tendon monitoring: advise patients to report sudden tendon pain or swelling.
  • QT‑prolonging drugs: avoid concurrent use with other agents that affect cardiac repolarisation.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levofloxacine Teva can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levofloxacin absorption.
  • NSAIDs (e.g., ibuprofen): increase risk of CNS stimulation and seizures.
  • Warfarin: potentiate anticoagulant effect, raising bleeding risk.
  • Cyclosporine: elevate levofloxacin plasma concentrations.
  • Theophylline: increase theophylline toxicity.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may reduce contraceptive efficacy.
  • Corticosteroids: heighten risk of tendon rupture.
  • Diabetic agents: possible alterations in blood glucose control.
  • SSRIs: additive effect on QT interval prolongation.
  • Rifampin: may lower levofloxacin levels, reducing efficacy.

Frequently Asked Questions

Levofloxacine Teva is prescribed for a variety of bacterial infections, including community‑acquired respiratory tract infections, acute bacterial sinusitis, exacerbations of chronic bronchitis, uncomplicated urinary tract infections, skin and soft‑tissue infections, and bacterial prostatitis. The choice of therapy depends on the susceptibility of the pathogen and the clinical judgment of the prescriber.

Levofloxacin blocks two essential bacterial enzymes—DNA gyrase (topoisomerase II) and topoisomerase IV—preventing DNA replication and transcription. This inhibition leads to bacterial cell death, providing a bactericidal effect against a broad range of Gram‑positive and Gram‑negative organisms.

The dosage regimen for Levofloxacine Teva is determined by the treating physician based on the specific infection, patient age, renal function, and other clinical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for levofloxacin in pregnancy and lactation are limited. It should be used only if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Levofloxacin is a third‑generation fluoroquinolone offering once‑daily dosing and a broad spectrum of activity, often preferred over older fluoroquinolones for its enhanced potency against respiratory pathogens. Compared with macrolides or beta‑lactams, it provides faster bacterial eradication but carries class‑specific risks such as tendon injury and QT prolongation, which must be weighed by the prescriber.

Levofloxacine Teva should be stored at temperatures below 25 °C, in its original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.

The medication is taken orally, usually with a full glass of water. It may be taken with or without food, but antacids containing aluminum or magnesium should be spaced at least two hours apart to avoid reduced absorption. Swallow tablets whole; do not crush or chew unless specifically instructed.

Serious adverse events include tendon rupture or tendinitis, especially in older adults; QT interval prolongation leading to potentially life‑threatening arrhythmias; severe hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome; Clostridioides difficile‑associated colitis; and peripheral neuropathy. Patients should seek immediate medical attention if they experience sudden tendon pain, palpitations, rash, or neurological symptoms.

Levofloxacine Teva is contraindicated in individuals with a known hypersensitivity to levofloxacin or other fluoroquinolones. It should also be avoided in patients with a history of tendon disorders related to fluoroquinolone use, those with significant QT prolongation, and in pregnant or lactating women unless no safer alternative exists. Children and adolescents should not receive this drug for certain indications due to the risk of musculoskeletal adverse effects.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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