Levofloxacine Zentiva (Levofloxacin Hemihydrate)

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes that unwind and reseal DNA during replication and transcription. By preventing these processes, the drug halts bacterial growth and leads to cell death, providing a bactericidal effect against many Gram‑positive and Gram‑negative organisms.

The exact dosage of Levofloxacine Zentiva is determined by the prescribing clinician based on the infection type, severity, patient age, renal function, and other clinical factors. Only a qualified health professional can set the appropriate regimen.

Safety data for levofloxacin in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Levofloxacine Zentiva contains levofloxacin, the L‑isomer of ofloxacin, offering a broader spectrum and higher potency against many pathogens. Compared with older fluoroquinolones, it often requires once‑daily dosing and has a lower risk of certain resistance mechanisms, though safety considerations such as tendon toxicity remain similar across the class.

Levofloxacine Zentiva should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, controlled environment helps maintain its stability and potency throughout its shelf life.

Levofloxacine Zentiva is taken orally, usually with a full glass of water. It may be taken with or without food, but antacids or supplements containing aluminum, magnesium, calcium, iron, or zinc should be spaced at least two hours apart to avoid reduced absorption.

Serious risks include tendon rupture (especially Achilles tendon), QT interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, and Clostridioides difficile‑associated colitis. Patients should be advised to seek immediate medical attention if they experience sudden tendon pain, palpitations, severe rash, or persistent diarrhea.

Levofloxacine Zentiva is contraindicated in patients with a known hypersensitivity to levofloxacin, other fluoroquinolones, or any of the product excipients. It should also be avoided in individuals with a history of tendon disorders related to fluoroquinolone use, and in patients with established QT prolongation unless benefits outweigh risks.