Product image of Levofloxacine Zonder Conserveermiddel Rafarm (Levofloxacin Hemihydrate) supplied by GNH India

Levofloxacine Zonder Conserveermiddel Rafarm

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Levofloxacine Zonder Conserveermiddel Rafarm (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Levofloxacine Zonder Conserveermiddel Rafram, is a fluoroquinolone antibiotic presented as a sterile ophthalmic solution for ocular use. It treats bacterial eye infections such as conjunctivitis and keratitis by eliminating the causative microorganisms.
GNH India supplies Levofloxacine Zonder Conserveermiddel Rafram as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rafarm Sa.

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Indications & Clinical Uses

Levofloxacin ophthalmic solution is employed to manage bacterial infections of the eye and to prevent postoperative ocular contamination.

  • Bacterial conjunctivitis: reduces bacterial load and accelerates resolution of infection.
  • Bacterial keratitis: eradicates pathogenic bacteria in corneal ulcers, promoting healing.
  • Post‑surgical prophylaxis: prevents bacterial colonisation after cataract or refractive surgery.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription and repair. By blocking these targets, it prevents bacterial cell division and leads to rapid bacterial cell death, providing a bactericidal effect against susceptible ocular pathogens.

Side Effects

Levofloxacine ophthalmic solution may cause local and systemic adverse reactions.

Common Side Effects

  • Eye irritation or burning sensation.
  • Redness of the conjunctiva.
  • Tearing or increased lacrimation.
  • Foreign body sensation.
  • Blurred vision.
  • Mild headache.

Serious or Rare Side Effects

  • Allergic reaction (e.g., eyelid swelling, rash).
  • Corneal ulceration or thinning.
  • Severe ocular inflammation.
  • Tendon rupture (systemic exposure).
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Levofloxacine ophthalmic solution requires careful handling to minimise risks.

  • Hypersensitivity: avoid use in patients with known fluoroquinolone allergy.
  • Solution integrity: do not use if the product appears discoloured or contains particles.
  • Systemic exposure: monitor for tendon pain or rupture, especially in elderly patients.
  • Renal impairment: use with caution; adjust therapy if systemic absorption is suspected.
  • Pregnancy and lactation: safety not established; weigh benefits against potential risks.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Levofloxacine ophthalmic solution can interact with other medications, primarily when systemic absorption occurs.

Major Interactions (Avoid)

  • Concurrent systemic fluoroquinolones: additive toxicity risk.
  • Systemic NSAIDs: increased risk of tendon rupture.
  • Corticosteroid eye drops: heightened chance of corneal complications.

Moderate Interactions (Monitor Closely)

  • Antacids or multivalent cations (if systemic exposure): may reduce fluoroquinolone absorption.
  • Warfarin: possible enhancement of anticoagulant effect.
  • Oral hypoglycaemic agents: potential for hypoglycaemia.

Frequently Asked Questions

Levofloxacine Zonder Conserveermiddel is an ophthalmic formulation of levofloxacin used to treat bacterial infections of the eye, such as conjunctivitis, keratitis, and to prevent infection after ocular surgery.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. This inhibition stops bacterial cell division, leading to rapid bacterial death and resolution of the infection.

The dosing regimen for Levofloxacine Zonder Conserveermiddel is determined by the prescribing clinician based on the specific infection, severity, and patient factors. The prescriber will provide the appropriate frequency and duration.

Safety data for levofloxacin in pregnancy and lactation are limited. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levofloxacine belongs to the fluoroquinolone class, offering broad‑spectrum coverage against Gram‑negative and some Gram‑positive bacteria. Compared with older agents like ciprofloxacin, levofloxacin often provides higher potency with once‑daily dosing, though choice depends on local resistance patterns and clinician preference.

Store the ophthalmic solution at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect it from light and moisture, and discard any product that appears discoloured or contains particles.

Levofloxacine is applied as sterile eye drops directly onto the affected eye(s) according to the prescriber’s instructions, typically using a clean fingertip to lower the eyelid and instilling the recommended number of drops.

Serious risks include severe allergic reactions, corneal ulceration, tendon rupture (especially in older patients), and rare systemic hypersensitivity syndromes such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience any of these symptoms.

Individuals with a known hypersensitivity to levofloxacin or any fluoroquinolone should avoid this product. Caution is also advised for patients with a history of tendon disorders, severe renal impairment, or those who are pregnant or breastfeeding unless clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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