Product image of Levofloxacino Altan (Levofloxacin) supplied by GNH India

Levofloxacino Altan

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacino Altan (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacino Altan, is a fluoroquinolone antibiotic presented as an injection for intravenous use. It treats a range of bacterial infections in adult patients, including community‑acquired pneumonia, complicated urinary tract infections, intra‑abdominal infections, skin and soft‑tissue infections, and acute bacterial sinusitis.

GNH India supplies Levofloxacino Altan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Altan Pharmaceuticals S.A.

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Indications & Clinical Uses

Levofloxacino Altan is a fluoroquinolone antibacterial used for several serious bacterial infections.

  • Community‑acquired pneumonia: achieves bacterial eradication and clinical cure in adult patients.
  • Complicated urinary tract infections: eliminates pathogenic organisms causing upper and lower urinary tract disease.
  • Complicated intra‑abdominal infections: provides broad‑spectrum coverage for mixed aerobic and anaerobic flora.
  • Skin and soft‑tissue infections: resolves cellulitis, abscesses and other bacterial skin conditions.
  • Acute bacterial sinusitis: clears sinus pathogens and relieves symptoms.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to these enzymes, it prevents the unwinding of DNA, halting bacterial replication and transcription, which leads to bacterial cell death. This bactericidal action is effective against a wide range of Gram‑positive and Gram‑negative organisms.

Side Effects

Levofloxacino Altan may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional vertigo or light‑headedness.
  • Rash: mild skin erythema or pruritus.
  • Elevated liver enzymes: transient increase in ALT/AST.

Serious or Rare Side Effects

  • Tendon rupture: especially Achilles tendon, may occur without warning.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Severe allergic reactions: anaphylaxis, angioedema.
  • Clostridioides difficile infection: colitis with watery diarrhea.
  • Peripheral neuropathy: sensory disturbances, tingling.
  • Stevens‑Johnson syndrome/toxic epidermal necrolysis: severe skin reactions.

Precautions & Warnings

Levofloxacino Altan requires careful patient assessment before use.

  • Renal impairment: dose adjustment may be needed based on creatinine clearance.
  • History of tendon disorders: avoid in patients with prior tendon injury.
  • Cardiac arrhythmias: monitor QT interval in patients with known prolongation.
  • Concomitant CNS disorders: use cautiously in patients with seizures.
  • Pregnancy and lactation: safety not established; avoid unless clearly needed.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levofloxacino Altan can interact with several medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levofloxacin absorption.
  • Warfarin: may increase INR and bleeding risk.
  • Theophylline: elevated plasma levels can cause toxicity.
  • Cyclosporine: increased cyclosporine concentrations.
  • NSAIDs: heightened risk of CNS stimulation and seizures.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: increased chance of tendon rupture.
  • Oral contraceptives: reduced hormonal efficacy.
  • Diabetic agents: potential for hypoglycemia.
  • QT‑prolonging drugs (e.g., macrolides): monitor cardiac rhythm.
  • Diuretics: may enhance hypokalemia, affecting cardiac safety.

Frequently Asked Questions

Levofloxacino Altan is indicated for serious bacterial infections such as community‑acquired pneumonia, complicated urinary tract infections, complicated intra‑abdominal infections, skin and soft‑tissue infections, and acute bacterial sinusitis. It is administered intravenously in a hospital setting to achieve rapid bacterial clearance.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By preventing DNA unwinding, the drug stops bacterial cell division, leading to bactericidal activity against a broad spectrum of Gram‑positive and Gram‑negative organisms.

The specific dose and duration are determined by the prescribing clinician based on the infection type, severity, patient weight, renal function, and local guidelines. Healthcare professionals should follow the product label and institutional protocols when prescribing.

Safety data for levofloxacin in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Levofloxacin offers a once‑daily dosing schedule and broad‑spectrum activity comparable to other fluoroquinolones such as ciprofloxacin. It has a higher potency against Gram‑positive organisms and better lung penetration, making it a preferred choice for respiratory infections, while maintaining a similar safety profile.

Levofloxacino Altan should be stored at 2‑8 °C in a refrigerator. Keep the vials in their original packaging, protect them from light, and do not freeze or shake the solution. Maintain the temperature range throughout transport and storage.

The product is supplied as a sterile injection for intravenous infusion. It is administered by a qualified healthcare professional, typically diluted in an appropriate IV fluid and infused over a set period according to the prescribing information and patient condition.

Serious adverse events include tendon rupture (especially Achilles), QT interval prolongation leading to arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, peripheral neuropathy, and rare skin reactions like Stevens‑Johnson syndrome. Prompt medical attention is required if any of these occur.

Patients with a known hypersensitivity to levofloxacin or other fluoroquinolones should avoid the drug. It is also contraindicated in individuals with a history of tendon disorders related to fluoroquinolone use, those with significant QT prolongation, and patients with severe renal impairment without appropriate dose adjustment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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