Product image of Levofloxacino Aristo (Levofloxacin Hemihydrate) supplied by GNH India

Levofloxacino Aristo

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Levofloxacino Aristo (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Levofloxacino Aristo, is a fluoroquinolone presented as an oral dosage form for oral use. It is employed to treat a range of bacterial infections, including urinary, respiratory, skin, prostatitis, and gonorrhea, in adult patients.

GNH India supplies Levofloxacino Aristo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and ensuring consistent batch release and regulatory compliance for global distribution.

Manufacturer / TM Owner

Aristo Pharma Gmbh (Art 57)

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Indications & Clinical Uses

Levofloxacin is a fluoroquinolone antibacterial that interferes with bacterial DNA replication and is indicated for several infection types.

  • Urinary tract infections: eradicates susceptible uropathogens and relieves urinary symptoms.
  • Respiratory tract infections: treats community‑acquired pneumonia, acute exacerbations of chronic bronchitis, and other bacterial respiratory diseases.
  • Skin and soft tissue infections: resolves infections caused by susceptible Gram‑positive and Gram‑negative organisms.
  • Prostatitis: achieves bacterial clearance in chronic bacterial prostatitis.
  • Gonorrhea: provides microbiological cure of uncomplicated gonococcal infection.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to these enzymes, it prevents the unwinding of DNA, halting bacterial replication and transcription, which leads to bacterial cell death. The drug exhibits concentration‑dependent bactericidal activity against a broad spectrum of Gram‑positive and Gram‑negative organisms.

Side Effects

Levofloxacin may cause a range of adverse reactions, from mild to severe. Patients should be aware of both common and serious possibilities.

Common Side Effects

  • Nausea: mild gastrointestinal upset occurring in many patients.
  • Diarrhea: loose stools that are usually self‑limiting.
  • Headache: transient cranial discomfort.

Serious or Rare Side Effects

  • Tendon rupture: sudden tendon pain or swelling, especially in the Achilles tendon.
  • QT interval prolongation: may predispose to cardiac arrhythmias.
  • Severe allergic reaction: rash, angioedema, or anaphylaxis requiring immediate medical attention.

Precautions & Warnings

Levofloxacino Aristo requires careful consideration of patient‑specific factors and proper handling.

  • Renal function assessment: adjust therapy in patients with impaired renal clearance.
  • Hypersensitivity screening: avoid use in individuals with known allergy to fluoroquinolones.
  • Elderly caution: monitor for tendon pain and central nervous system effects.
  • Concomitant QT‑prolonging drugs: evaluate cardiac risk before co‑administration.
  • Store below 25°C: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Levofloxacin can interact with several medication classes, influencing safety and efficacy.

Major Interactions (Avoid)

  • Other fluoroquinolones: additive toxicity risk.
  • QT‑prolonging agents (e.g., quinidine, amiodarone): increased risk of arrhythmia.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): heightened tendon‑rupture risk.

Moderate Interactions (Monitor Closely)

  • Antacids or supplements containing magnesium/aluminum: may reduce levofloxacin absorption.
  • Warfarin: potential alteration of INR, requiring coagulation monitoring.
  • Corticosteroids: synergistic effect on tendon toxicity.
  • Oral contraceptives: possible reduction in contraceptive efficacy.

Frequently Asked Questions

Levofloxacino Aristo, containing levofloxacin, is prescribed for bacterial urinary tract infections, respiratory tract infections such as pneumonia and bronchitis, skin and soft‑tissue infections, chronic bacterial prostatitis, and uncomplicated gonorrhea. The drug targets susceptible organisms in these conditions, helping to clear the infection and alleviate symptoms.

Levofloxacin inhibits two key bacterial enzymes—DNA gyrase (topoisomerase II) and topoisomerase IV. By binding to these enzymes, it prevents DNA supercoiling and replication, which stops bacterial cell division and leads to bacterial death. This mechanism provides broad‑spectrum bactericidal activity against many Gram‑positive and Gram‑negative pathogens.

The specific dosage of Levofloxacino Aristo is determined by the prescribing clinician based on the infection type, severity, patient age, weight, and renal function. Healthcare professionals follow local guidelines and product labeling to select the appropriate strength and duration for each individual case.

Safety data for levofloxacin in pregnancy and lactation are limited, and the drug is generally avoided unless the potential benefit outweighs the risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To request Levofloxacino Aristo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any temperature requirements) and necessary import documentation.

Levofloxacin offers broad‑spectrum coverage and convenient once‑daily oral dosing, which can be advantageous over some beta‑lactams that require multiple daily doses. However, fluoroquinolones carry specific safety warnings (e.g., tendon toxicity, QT prolongation) that may make clinicians prefer other classes when equally effective alternatives are available.

Levofloxacino Aristo should be stored below 25 °C in a dry place, protected from moisture and direct sunlight. Keep the product in its original packaging until use to maintain stability and potency throughout its shelf life.

Levofloxacino Aristo is taken orally, usually with a full glass of water. It can be taken with or without food, but patients should avoid concurrent intake of antacids or mineral supplements containing magnesium or aluminum, as these may reduce absorption.

Serious risks include tendon rupture (especially Achilles tendon), QT interval prolongation leading to arrhythmias, severe allergic reactions such as anaphylaxis, and Clostridioides difficile‑associated diarrhea. Patients should promptly report tendon pain, palpitations, or signs of an allergic reaction to their healthcare provider.

Levofloxacino Aristo is contraindicated in individuals with a known hypersensitivity to levofloxacin or any fluoroquinolone. Caution is also advised for patients with a history of tendon disorders, prolonged QT interval, or those taking medications that significantly prolong QT. Pregnant or breastfeeding women should only use it if clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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