Product image of Levofloxacino Krka (Levofloxacin) supplied by GNH India

Levofloxacino Krka

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacino Krka (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacino Krka, is a fluoroquinolone antibiotic presented as an oral tablet for oral use. It treats a range of bacterial infections, including respiratory, urinary and skin infections, in adult patients.
GNH India supplies Levofloxacino Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Levofloxacin is indicated for bacterial infections affecting several organ systems.

  • Community‑acquired pneumonia: eradicates the causative pathogens and improves respiratory function.
  • Acute bacterial sinusitis: reduces sinus inflammation and clears infection.
  • Acute exacerbation of chronic bronchitis: controls bacterial overgrowth and eases bronchial symptoms.
  • Uncomplicated urinary tract infection: eliminates uropathogens and resolves urinary symptoms.
  • Complicated urinary tract infection: provides bactericidal activity against resistant strains in the urinary tract.
  • Skin and soft‑tissue infections: treats cellulitis, abscesses and other bacterial skin conditions.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription and repair. By stabilizing the enzyme‑DNA complex, it prevents the resealing of DNA strands, leading to bacterial cell death and a bactericidal effect against susceptible organisms.

Side Effects

Levofloxacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Abdominal pain: cramping or discomfort in the stomach area.
  • Rash: mild skin erythema or itching.

Serious or Rare Side Effects

  • Tendon rupture: sudden tendon pain or loss of function, especially in the Achilles.
  • QT interval prolongation: potential cardiac arrhythmias.
  • Clostridioides difficile infection: severe colitis with watery diarrhea.
  • Anaphylaxis: rapid onset of severe allergic reaction.
  • Peripheral neuropathy: numbness or tingling in extremities.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.

Precautions & Warnings

Before prescribing Levofloxacino Krka, clinicians should consider several safety measures.

  • Renal function assessment: adjust dose in patients with impaired kidney function.
  • Hypersensitivity screening: avoid in individuals with known fluoroquinolone allergy.
  • Elderly caution: monitor for tendon pain and central nervous system effects.
  • Tendon monitoring: discontinue if sudden tendon pain or swelling occurs.
  • QT‑prolonging drugs: avoid concurrent use with other agents that lengthen the QT interval.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levofloxacino Krka can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect and INR.
  • NSAIDs: heightened risk of central nervous system stimulation.
  • Cyclosporine: increased cyclosporine serum concentrations.
  • Theophylline: elevated theophylline levels and toxicity risk.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: possible reduction in contraceptive effectiveness.
  • Corticosteroids: increased risk of tendon rupture.
  • Diabetic agents: enhanced hypoglycemic effect.
  • SSRIs: additive QT‑prolongation potential.
  • Rifampin: decreased levofloxacin plasma concentrations.

Frequently Asked Questions

Levofloxacino Krka is prescribed for bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, acute exacerbations of chronic bronchitis, uncomplicated and complicated urinary tract infections, and skin or soft‑tissue infections caused by susceptible organisms.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. This inhibition prevents the resealing of DNA strands, leading to bacterial cell death and a bactericidal effect against a broad range of gram‑negative and gram‑positive pathogens.

The dosage of Levofloxacino Krka is determined by the prescribing clinician based on the specific infection, severity, patient age, renal function and other clinical factors. Patients should follow the exact regimen provided by their healthcare professional.

Levofloxacino Krka falls under an unknown pregnancy category, and fluoroquinolones are generally avoided unless the potential benefit justifies the risk. It is also excreted in breast milk, so breastfeeding mothers should discuss alternatives with their physician.

To request Levofloxacino Krka, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levofloxacin offers broad‑spectrum coverage, including many gram‑negative organisms, and provides once‑daily dosing for several infections, which can be an advantage over beta‑lactams that may require multiple daily doses. However, resistance patterns, safety profile and specific pathogen susceptibility guide the choice of alternative agents.

Levofloxacino Krka should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Maintaining these conditions helps preserve tablet potency throughout its shelf life.

Levofloxacino Krka is taken orally, usually with a full glass of water. It can be taken with or without food, but antacids containing aluminum or magnesium should be spaced at least two hours apart to avoid reduced absorption.

Serious risks include tendon rupture (especially the Achilles tendon), QT interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, peripheral neuropathy, and hepatic injury. Patients should seek immediate medical attention if they experience any of these symptoms.

Levofloxacino Krka should be avoided in individuals with a known hypersensitivity to fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, patients taking other QT‑prolonging drugs without close monitoring, and patients with severe renal impairment unless dose‑adjusted by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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