Product image of Levofloxacino Tarbis (Levofloxacin) supplied by GNH India

Levofloxacino Tarbis

Active Ingredient:
Levofloxacin
Origin:
EU

Levofloxacino Tarbis (Levofloxacin)

Levofloxacin, the active ingredient in Levofloxacino Tarbis, is a fluoroquinolone antibiotic presented as an oral dosage form for systemic use. It treats a range of bacterial infections in adults and children when prescribed by a qualified health professional. It is indicated for infections of the respiratory, urinary and skin systems and is effective against both Gram‑positive and Gram‑negative pathogens.

GNH India supplies Levofloxacino Tarbis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑ready documentation for each batch.

Manufacturer / TM Owner

Tarbis Farma, S.L.

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Indications & Clinical Uses

Levofloxacin is a broad‑spectrum fluoroquinolone used to treat bacterial infections affecting several organ systems.

  • Community‑Acquired Pneumonia: shortens disease duration and improves clinical cure rates in adults.
  • Acute Bacterial Sinusitis: eradicates the causative pathogens, relieving sinus congestion and facial pain.
  • Uncomplicated Urinary Tract Infection: eliminates uropathogens, leading to rapid symptom resolution.
  • Skin and Soft‑Tissue Infections: controls Gram‑positive and Gram‑negative bacteria, promoting wound healing.
  • Chronic Bacterial Prostatitis: reduces bacterial load in the prostate, alleviating urinary symptoms.

How It Works

  • Levofloxacin exerts its antibacterial activity by binding to bacterial DNA gyrase (topoisomerase II) and topoisomerase IV. This inhibition prevents the supercoiling and relaxation of DNA that are essential for replication and transcription, leading to bacterial cell death. The dual targeting of both enzymes provides potent activity against a wide range of Gram‑positive and Gram‑negative organisms, including many resistant strains.

Side Effects

Levofloxacin may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Tendon rupture or inflammation
  • QT interval prolongation leading to arrhythmia
  • Clostridioides difficile‑associated colitis
  • Severe allergic reactions such as anaphylaxis
  • Peripheral neuropathy
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis

Precautions & Warnings

Levofloxacin requires careful patient assessment and monitoring.

  • Assess renal function: dose adjustment may be required in impaired clearance.
  • Avoid use in patients with a history of tendon disorders: risk of tendon rupture is increased.
  • Use cautiously in individuals with known QT prolongation or electrolyte abnormalities.
  • Monitor for hypersensitivity reactions: discontinue if rash or anaphylaxis develops.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levofloxacin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Antacids or supplements containing aluminum, magnesium or calcium: markedly reduce levofloxacin absorption.
  • NSAIDs (e.g., ibuprofen, naproxen): increase risk of central nervous system stimulation and seizures.
  • Corticosteroids: combined use heightens risk of tendon rupture.

Moderate Interactions (Monitor Closely)

  • Warfarin: levofloxacin may enhance anticoagulant effect, requiring INR monitoring.
  • Theophylline: possible increase in plasma concentrations, watch for toxicity.
  • QT‑prolonging drugs (e.g., macrolides, other fluoroquinolones): may compound cardiac risk.

Frequently Asked Questions

Levofloxacino Tarbis contains levofloxacin, a fluoroquinolone antibiotic that is prescribed for a variety of bacterial infections such as community‑acquired pneumonia, urinary tract infections, skin and soft‑tissue infections, and certain sinus or bronchial infections. The specific indication depends on the clinician’s assessment of the infection type and severity.

Levofloxacin inhibits two essential bacterial enzymes: DNA gyrase (topoisomerase II) and topoisomerase IV. By blocking these enzymes, the drug prevents DNA supercoiling and replication, leading to bacterial cell death. This dual mechanism gives levofloxacin activity against many Gram‑positive and Gram‑negative organisms, including some resistant strains.

The dose is set by the prescribing healthcare professional based on the type and severity of the infection, the patient’s age, weight, renal function, and any concomitant medications. Levofloxacin dosing can vary widely, so patients should follow the exact regimen written on the prescription label.

Safety data for levofloxacin in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and only under medical supervision.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After submission, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Levofloxacin offers broad‑spectrum coverage and convenient once‑daily oral dosing, which can be advantageous over some macrolides or beta‑lactams that require multiple daily doses. However, fluoroquinolones carry specific safety concerns such as tendon toxicity and QT prolongation, so clinicians weigh these risks against the benefits when selecting therapy.

Store the product at room temperature, below 25 °C (77 °F). Keep it in the original packaging to protect it from moisture and light. Do not store in a bathroom or near a heat source, and keep out of reach of children.

Levofloxacino Tarbis is taken orally with a full glass of water. It may be taken with or without food, but if gastrointestinal upset occurs, it can be taken with a light meal. Swallow tablets whole; do not crush or chew unless the formulation specifically permits it.

Serious adverse events include tendon rupture or inflammation, especially in older adults or those on corticosteroids; QT interval prolongation that can lead to life‑threatening arrhythmias; severe hypersensitivity reactions such as anaphylaxis; and Clostridioides difficile‑associated colitis. Patients should be instructed to seek immediate medical attention if they notice sudden joint pain, palpitations, severe rash or persistent diarrhea.

Individuals with a known hypersensitivity to levofloxacin or other fluoroquinolones should avoid the product. Patients with a history of tendon disorders, recent tendon injury, or those receiving concomitant corticosteroids are also contraindicated due to increased tendon‑rupture risk. Caution is advised in patients with prolonged QT interval, uncontrolled epilepsy, or severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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