Product image of Levofolene (Levoleucovorin) supplied by GNH India

Levofolene

Active Ingredient:
Levoleucovorin
Origin:
EU

Levofolene (Levoleucovorin)

Levoleucovorin, the active ingredient in Levofolene, is a folate analog presented as an injectable solution for intravenous use. It is employed to rescue patients from high‑dose methotrexate toxicity, to augment 5‑fluorouracil chemotherapy, and to prevent or treat folate deficiency in oncology settings.

GNH India supplies Levofolene as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides reliable global distribution.

Manufacturer / TM Owner

Alfasigma S.P.A.

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Indications & Clinical Uses

Levofolene is used in oncology and supportive care to address folate‑related pathways.

  • High‑dose methotrexate rescue: restores DNA synthesis and reduces toxicity after methotrexate therapy.
  • 5‑fluorouracil enhancement: stabilizes the drug‑enzyme complex to improve antitumor effect.
  • Folate deficiency prevention/treatment: supplies reduced folate to patients at risk of deficiency.

How It Works

  • Levoleucovorin provides a reduced form of folate that bypasses dihydrofolate reductase inhibition, allowing normal tetrahydrofolate‑dependent reactions to continue. This restores DNA synthesis in normal cells during methotrexate exposure and enhances the binding of 5‑fluorouracil to thymidylate synthase, increasing its cytotoxic effect on tumor cells.

Side Effects

Levofolene may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Vomiting: occasional emesis following infusion.
  • Rash: transient erythematous skin changes.
  • Headache: mild headache during or after administration.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Renal dysfunction: acute kidney injury in susceptible patients.
  • Hepatic toxicity: elevated liver enzymes or hepatic failure in rare cases.

Precautions & Warnings

Before initiating Levofolene therapy, consider the following precautions.

  • Renal function monitoring: assess creatinine clearance and adjust use in renal impairment.
  • Hepatic function monitoring: evaluate liver enzymes and avoid use in severe hepatic disease.
  • Known hypersensitivity: discontinue if allergic reactions occur.
  • Pregnancy considerations: use only if potential benefit justifies potential risk to the fetus.
  • Storage at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the vial.

Avoid Interactions

Levofolene can interact with several agents; awareness of the interaction level is essential.

Major Interactions (Avoid)

  • High‑dose methotrexate (improper timing): may increase toxicity if rescue is not correctly timed.
  • Pemetrexed (concurrent use): may diminish antitumor activity.

Moderate Interactions (Monitor Closely)

  • 5‑Fluorouracil (combined therapy): monitor for enhanced cytotoxicity.
  • Corticosteroids (long‑term use): may alter folate metabolism.
  • NSAIDs (renal clearance): observe renal function closely.

Frequently Asked Questions

Levofolene is used as a rescue agent after high‑dose methotrexate therapy, as an enhancer of 5‑fluorouracil chemotherapy, and to prevent or treat folate deficiency in patients receiving oncologic treatment.

Levoleucovorin supplies a reduced folate that bypasses the block created by dihydrofolate reductase inhibitors, allowing normal DNA synthesis in healthy cells and strengthening the binding of 5‑fluorouracil to thymidylate synthase, which improves its anticancer activity.

The dose of Levofolene is determined by the prescribing clinician based on the specific indication, patient weight, renal and hepatic function, and the timing relative to other chemotherapy agents.

Levofolene’s pregnancy category is unknown. It should only be used during pregnancy or lactation when the potential benefit outweighs any possible risk to the fetus or infant, and after careful evaluation by the treating physician.

To order Levofolene, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Levofolene (levoleucovorin) is a folate analog similar to leucovorin (folinic acid) but with a slightly different molecular structure. Both provide reduced folate for rescue, yet levoleucovorin may offer comparable efficacy with a distinct safety profile, making it an alternative when specific formulation or supply considerations apply.

Levofolene should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability.

Levofolene is given by intravenous infusion. The preparation and infusion rate are defined by the prescribing information and should be performed by qualified healthcare professionals in a clinical setting.

Serious risks include anaphylactic reactions, acute renal failure, and severe hepatic dysfunction. Patients should be monitored for signs of hypersensitivity, sudden changes in kidney or liver function, and any unexpected systemic symptoms during and after infusion.

Levofolene is contraindicated in individuals with known hypersensitivity to levoleucovorin or any component of the formulation, and it should be used with extreme caution or avoided in patients with severe renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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