Product image of Levofree (Levocabastine) supplied by GNH India

Levofree

Active Ingredient:
Levocabastine
Origin:
EU

Levofree (Levocabastine)

Levocabastine, the active ingredient in Levofree, is an antihistamine presented as an eye‑drop formulation for ocular use. It alleviates symptoms of allergic conjunctivitis by blocking histamine H1 receptors, thereby reducing redness, itching and watery discharge in affected individuals.

GNH India supplies Levofree as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑controlled sourcing from the European market and adherence to global regulatory standards. The company manages end‑to‑end logistics, documentation and customs clearance to facilitate reliable delivery across continents.

Manufacturer / TM Owner

Laboratoire Chauvin

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Indications & Clinical Uses

Levofree, an ocular antihistamine, acts on the histamine‑mediated pathway that underlies allergic eye disease.

  • Allergic conjunctivitis: reduces ocular itching, redness and tearing.
  • Seasonal allergic conjunctivitis: provides rapid relief of histamine‑driven symptoms during pollen seasons.
  • Vernal keratoconjunctivitis (mild cases): helps control inflammatory response and improves comfort.

How It Works

  • Levocabastine selectively antagonizes histamine H1 receptors on conjunctival mast cells and sensory nerves. By blocking these receptors, it prevents histamine‑induced vasodilation, increased vascular permeability, and nerve stimulation, thereby diminishing the classic signs of ocular allergy such as redness, edema, itching and watery discharge.

Side Effects

Levofree is generally well tolerated, but ocular antihistamines can cause local reactions.

Common Side Effects

  • Burning or stinging sensation at the application site.
  • Transient blurred vision after instillation.
  • Mild eye irritation or foreign‑body feeling.
  • Temporary conjunctival hyperemia.
  • Headache.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis) with swelling of the eyelids.
  • Corneal ulcer or epithelial defect.
  • Significant visual loss.
  • Ocular edema.
  • Persistent intraocular inflammation.

Precautions & Warnings

Before using Levofree, consider the following safety measures.

  • Assess patient history: confirm diagnosis of allergic conjunctivitis prior to treatment.
  • Avoid use in individuals with known hypersensitivity to levocabastine or other antihistamines.
  • Remove contact lenses before instillation and re‑insert after the drop has been absorbed.
  • Monitor for worsening ocular irritation; discontinue if severe reactions occur.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Levofree may interact with other ophthalmic or systemic agents.

Major Interactions (Avoid)

  • Concurrent use with monoamine oxidase inhibitors: may enhance systemic antihistamine effects.
  • Simultaneous administration of other ocular antihistamines: risk of additive irritation.
  • Co‑administration with prostaglandin analog eye drops: possible reduction in therapeutic efficacy.

Moderate Interactions (Monitor Closely)

  • Systemic antihistamines: may increase overall sedative burden.
  • Beta‑blocker eye drops: monitor intraocular pressure for potential changes.

Frequently Asked Questions

Levofree is an ophthalmic solution containing levocabastine, indicated for the relief of symptoms associated with allergic conjunctivitis. It helps reduce eye itching, redness, and watery discharge caused by histamine release in the conjunctiva.

Levocabastine is a selective histamine H1‑receptor antagonist. By binding to H1 receptors on conjunctival mast cells and sensory nerves, it blocks histamine‑mediated vasodilation and nerve activation, which diminishes the inflammatory signs of ocular allergy.

The specific dosing regimen is determined by the prescribing clinician. Typically, one drop is instilled into the affected eye(s) as needed, but the exact frequency and duration should follow the prescriber’s instructions.

Safety data for levocabastine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the Levofree product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levofree (levocabastine) offers rapid onset of action and a well‑characterised safety profile. Compared with agents such as olopatadine, levocabastine may cause slightly more transient stinging but is similarly effective in controlling itching and redness. Choice often depends on clinician preference and patient tolerance.

Levofree should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from direct light and moisture, and avoid freezing. Do not use the product after the expiration date printed on the label.

Levofree is applied topically to the eye. The patient should wash hands, tilt the head back, pull down the lower eyelid, and place a single drop into the conjunctival sac. Close the eye gently for a few seconds and avoid blinking excessively to allow absorption.

While uncommon, serious adverse events can include severe allergic reactions such as anaphylaxis, corneal ulceration, significant visual loss, or persistent ocular inflammation. Patients should seek immediate medical attention if they experience swelling of the eyelids, intense pain, or sudden vision changes.

Levofree should be avoided in individuals with a known hypersensitivity to levocabastine or any component of the formulation. It is also contraindicated in patients who have experienced severe ocular reactions to other antihistamine eye drops.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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