Product image of Levoftyal (Levofloxacin Hemihydrate) supplied by GNH India

Levoftyal

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Levoftyal (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Levoftyal, is a fluoroquinolone presented as an ophthalmic solution for ocular use. It is employed to treat bacterial infections of the eye in adult patients under medical supervision.

GNH India supplies Levoftyal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Unimed Pharma Spol.S R.O.

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Indications & Clinical Uses

Levoftyal is a fluoroquinolone antibiotic indicated for bacterial infections of the eye. It is applied directly to the ocular surface to eradicate susceptible pathogens.

  • Bacterial conjunctivitis: reduces bacterial load and accelerates symptom relief.
  • Bacterial keratitis: eradicates causative organisms and promotes corneal healing.
  • Post‑operative endophthalmitis: prevents or treats intra‑ocular infection after surgery.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By blocking these targets, the drug prevents bacterial cell division and leads to rapid bacterial cell death, providing a bactericidal effect against a broad spectrum of Gram‑positive and Gram‑negative ocular pathogens.

Side Effects

Levoftyal may cause local and systemic adverse reactions. Most events are mild and resolve after discontinuation.

Common Side Effects

  • Ocular burning or stinging sensation.
  • Redness of the conjunctiva.
  • Transient blurred vision.
  • Increased tearing or discharge.
  • Foreign‑body feeling in the eye.
  • Mild eyelid edema.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angioedema, anaphylaxis).
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Corneal ulceration or perforation.
  • Significant intra‑ocular inflammation.
  • Systemic hypersensitivity (e.g., rash, fever).

Precautions & Warnings

Levoftyal should be used with caution and under professional guidance.

  • Allergy to fluoroquinolones: discontinue immediately if hypersensitivity is observed.
  • Use only for the prescribed indication: avoid off‑label ocular use.
  • Contact lens wearers: remove lenses during treatment and until symptoms resolve.
  • Corneal epithelial defects: avoid use on compromised corneal surfaces.
  • Monitor for signs of severe ocular inflammation or systemic allergic response.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Levoftyal may interact with other ophthalmic or systemic agents.

Major Interactions (Avoid)

  • Concurrent systemic fluoroquinolones: risk of additive toxicity.
  • Topical corticosteroids: may delay wound healing and increase infection risk.

Moderate Interactions (Monitor Closely)

  • Other ophthalmic antibiotics: assess for antagonistic effects.
  • Non‑steroidal anti‑inflammatory eye drops: monitor for delayed corneal recovery.
  • Herbal supplements such as ginkgo biloba: may potentiate bleeding risk if systemic absorption occurs.
  • Antacids or multivitamins containing divalent cations: unlikely with ocular use but note systemic exposure.

Frequently Asked Questions

Levoftyal is an ophthalmic solution containing levofloxacin, a fluoroquinolone antibiotic. It is prescribed to treat bacterial infections of the eye such as conjunctivitis, keratitis, and post‑operative endophthalmitis, helping to eliminate pathogenic bacteria and relieve associated symptoms.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By inhibiting these targets, the drug prevents bacterial cell division, leading to rapid bacterial death and effective eradication of susceptible ocular pathogens.

The dosing regimen for Levoftyal is determined by the prescribing clinician based on the specific infection, severity, and patient factors. Healthcare professionals set the frequency and duration of eye‑drop administration in accordance with clinical guidelines.

Levoftyal’s pregnancy category is listed as unknown, and safety data are limited. Caution is advised when prescribing to pregnant or nursing women; the prescriber should weigh potential benefits against possible risks and consider alternative therapies if appropriate.

To request Levoftyal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Levoftyal belongs to the fluoroquinolone class, offering broad‑spectrum activity against Gram‑positive and Gram‑negative bacteria. Compared with older agents such as ciprofloxacin, levofloxacin provides enhanced potency and a lower risk of resistance development, while maintaining a similar safety profile for ocular use.

Levoftyal should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from direct light, moisture, and extreme temperatures to maintain stability. Do not freeze the solution, and keep the container tightly closed when not in use.

Levoftyal is applied directly to the affected eye(s) as prescribed. Typically, a few drops are instilled into the conjunctival sac, avoiding contact with the eyelid or lashes. Patients should wash their hands before and after administration and follow the dosing schedule provided by their eye‑care professional.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, toxic epidermal necrolysis, and corneal ulceration or perforation. Any signs of intense ocular pain, swelling, rash, or systemic symptoms should prompt immediate medical attention and discontinuation of the product.

Levoftyal is contraindicated in individuals with a known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation. It should also be avoided in patients with active corneal epithelial defects or severe ocular surface disease unless specifically directed by an ophthalmologist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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