Product image of Levogastrol (Levosulpiride) supplied by GNH India

Levogastrol

Active Ingredient:
Levosulpiride
Origin:
EU

Levogastrol (Levosulpiride)

Levosulpiride, the active ingredient in Levogastrol, is a benzamide derivative (dopamine D2 receptor antagonist) presented as an oral dosage form for oral use. It is employed in the management of certain psychiatric conditions and functional gastrointestinal disorders in adult patients.
GNH India supplies Levogastrol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorios Salvat, S.A.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Levosulpiride acts on dopaminergic pathways and gastrointestinal motility, making it useful for several psychiatric and gastro‑enterology indications.

  • Schizophrenia: reduces positive and negative symptoms by blocking central D2 receptors.
  • Depressive disorders: augments mood when used as an adjunctive therapy.
  • Functional dyspepsia: improves gastric emptying and relieves upper‑abdominal discomfort.
  • Gastroparesis: enhances gastric motility to alleviate delayed emptying.
  • Gastroesophageal reflux disease: reduces reflux episodes by promoting gastric clearance.

How It Works

  • Levosulpiride selectively antagonizes dopamine D2 receptors in the central nervous system, which modulates psychotic and mood symptoms. Peripheral D2 blockade in the gastrointestinal tract increases acetylcholine release, enhancing smooth‑muscle contractility and accelerating gastric emptying, thereby improving motility‑related disorders.

Side Effects

Levosulpiride may be associated with a range of adverse reactions.

Common Side Effects

  • Drowsiness: mild sedation or fatigue.
  • Extrapyramidal symptoms: tremor, rigidity, or akathisia.
  • Gastrointestinal upset: nausea, abdominal cramps, or diarrhea.
  • Elevated prolactin: menstrual irregularities or galactorrhea.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: high fever, muscle rigidity, autonomic instability.
  • Severe extrapyramidal reactions: tardive dyskinesia or dystonia.
  • Cardiac arrhythmias: QT prolongation in susceptible individuals.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor appropriately.

  • Pregnancy: safety not established; avoid unless benefits outweigh risks.
  • Breastfeeding: excreted in milk; assess infant risk before use.
  • Renal impairment: dose adjustment may be required in severe dysfunction.
  • Elderly: increased sensitivity to extrapyramidal effects; start at low dose.
  • Concomitant CNS depressants: may enhance sedation.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Levosulpiride can interact with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Antipsychotics with strong D2 antagonism: may exacerbate extrapyramidal symptoms.
  • QT‑prolonging agents (e.g., macrolides, fluoroquinolones): increase risk of cardiac arrhythmias.
  • CYP3A4 inhibitors (e.g., ketoconazole): raise plasma concentrations.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines): enhanced sedation.
  • Anticholinergic drugs: may counteract pro‑kinetic effect.
  • Dopamine agonists (e.g., levodopa): reduced therapeutic efficacy.

Frequently Asked Questions

Levogastrol, containing levosulpiride, is indicated for schizophrenia, depressive disorders as an adjunct, functional dyspepsia, gastroparesis, and gastro‑oesophageal reflux disease. It works by modulating dopamine pathways in the brain and enhancing gastrointestinal motility.

Levosulpiride selectively blocks dopamine D2 receptors in the central nervous system, reducing psychotic symptoms, and also antagonises peripheral D2 receptors, which increases acetylcholine release and promotes smooth‑muscle contraction, thereby improving gastric emptying and digestive function.

The dosage of Levogastrol is individualized by the prescribing clinician based on the specific indication, patient age, renal function, and response. Healthcare professionals determine the appropriate strength, frequency, and duration of therapy.

Safety data for levosulpiride in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Levogastrol product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with typical antipsychotics, levosulpiride has a more selective D2 antagonism, often resulting in fewer metabolic side effects but a higher propensity for prolactin elevation. In gastro‑prokinetic therapy, it offers a dual benefit of central dopamine blockade and enhanced gastric motility, distinguishing it from agents like metoclopramide.

Levogastrol should be stored at ambient temperature, below 25 °C, in its original packaging to protect from moisture and light. Do not store in areas with high humidity or extreme heat.

Levogastrol is taken orally, usually with or without food, as directed by the prescribing clinician. The tablet should be swallowed whole with water and not chewed or crushed unless specifically instructed.

Serious risks include neuroleptic malignant syndrome, severe extrapyramidal reactions such as tardive dyskinesia, significant QT interval prolongation leading to arrhythmias, and marked hyperprolactinemia that can cause endocrine disturbances.

Levogastrol is contraindicated in patients with known hypersensitivity to levosulpiride or other benzamide derivatives, those with a history of neuroleptic malignant syndrome, and individuals taking other potent D2 antagonists without medical supervision. Caution is advised in patients with severe cardiac, hepatic, or renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Levosulpiride

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT