Product image of Levogenix (Lansoprazole) supplied by GNH India

Levogenix

Active Ingredient:
Lansoprazole
Origin:
EU

Levogenix (Lansoprazole)

Lansoprazole, the active ingredient in Levogenix, is a proton pump inhibitor presented as an oral tablet for oral use. It reduces gastric acid production and is used to treat conditions such as gastro‑esophageal reflux disease, peptic ulcer disease, erosive esophagitis, and as part of Helicobacter pylori eradication regimens in adult patients.

GNH India supplies Levogenix as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide. The company adheres to European Union quality standards and provides reliable sourcing for clinical and retail settings.

Manufacturer / TM Owner

Genetic Spa

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Indications & Clinical Uses

Levogenix (lansoprazole) is employed to manage acid‑related gastrointestinal disorders. It acts on the gastric proton pump to lower acid secretion, benefiting several conditions.

  • Gastro‑esophageal reflux disease (GERD): reduces acid exposure and promotes healing of the esophageal lining.
  • Peptic ulcer disease: facilitates ulcer healing by decreasing gastric acidity.
  • Erosive esophagitis: alleviates mucosal damage caused by refluxed acid.
  • Helicobacter pylori eradication (in combination therapy): enhances the effectiveness of antibiotic regimens by providing a less acidic environment.

How It Works

  • Lansoprazole irreversibly binds to the H+/K+ ATPase enzyme (gastric proton pump) located on the secretory surface of parietal cells. By inhibiting this final step of acid secretion, it markedly reduces both basal and stimulated gastric acid output, allowing the gastric mucosa to heal and decreasing reflux‑related injury.

Side Effects

Adverse reactions may occur with any medication. The following lists reported events associated with lansoprazole use.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhea: loose stools, sometimes watery.
  • Nausea: feeling of queasiness or upset stomach.
  • Abdominal pain: discomfort or cramping in the stomach area.
  • Flatulence: increased gas production.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Clostridioides difficile infection: severe colitis presenting with diarrhea.
  • Severe allergic reactions: anaphylaxis, angioedema, or skin rash.
  • Interstitial nephritis: kidney inflammation with reduced function.
  • Elevated liver enzymes: signs of hepatic stress.
  • Long‑term bone fracture risk: decreased calcium absorption potentially leading to fractures.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess renal function: adjust use in patients with severe impairment.
  • Review hepatic status: use with caution in moderate liver disease.
  • Monitor for drug interactions: especially with clopidogrel, atazanavir, and methotrexate.
  • Limit duration of use: avoid indefinite therapy without periodic reassessment.
  • Discontinue before certain surgeries: evaluate need for acid suppression peri‑operatively.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Lansoprazole can affect the pharmacokinetics of several co‑administered medicines.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect, increasing cardiovascular risk.
  • Atazanavir: decreased absorption, leading to sub‑therapeutic HIV control.
  • HIV protease inhibitors (e.g., ritonavir): altered plasma levels.
  • Methotrexate: increased toxicity due to reduced clearance.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible INR elevation, requiring dose adjustment.
  • Digoxin: increased serum concentration, risk of toxicity.
  • Phenytoin: reduced levels, potentially decreasing seizure control.
  • Fluconazole: may raise lansoprazole concentrations, monitor for side effects.

Frequently Asked Questions

Levogenix contains lansoprazole, a proton pump inhibitor that is prescribed to lower stomach acid. It is commonly used to treat gastro‑esophageal reflux disease, peptic ulcer disease, erosive esophagitis, and as part of combination therapy for Helicobacter pylori eradication.

Lansoprazole blocks the H+/K+ ATPase enzyme, also known as the gastric proton pump, on the surface of parietal cells. By irreversibly inhibiting this pump, it stops the final step of acid secretion, leading to a marked reduction in gastric acidity.

The appropriate dose of Levogenix is determined by the prescribing clinician based on the specific condition, severity, and patient characteristics. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for lansoprazole in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To request Levogenix, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levogenix (lansoprazole) belongs to the proton pump inhibitor class, which generally provides more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with other PPIs, its efficacy and safety profile are similar, with differences mainly in pharmacokinetic properties and dosing frequency.

Levogenix should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, heat and direct sunlight to maintain stability.

Levogenix is taken orally, usually as a whole tablet swallowed with water. It is generally recommended to take the medication before a meal, but patients should follow the specific instructions provided by their prescriber.

Serious adverse events, although rare, can include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, interstitial nephritis, and significant elevations in liver enzymes. Patients should seek immediate medical attention if they experience symptoms like rash, difficulty breathing, persistent diarrhea, or jaundice.

Levogenix is contraindicated in individuals with known hypersensitivity to lansoprazole or any component of the formulation. Caution is advised for patients with severe liver disease, those taking medications that have major interactions, and patients who have experienced previous severe reactions to proton pump inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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