Product image of Levomepromazin Neuraxpharm (Levomepromazine Hydrochloride) supplied by GNH India

Levomepromazin Neuraxpharm

Active Ingredient:
Levomepromazine Hydrochloride
Origin:
EU

Levomepromazin Neuraxpharm (Levomepromazine Hydrochloride)

Levomepromazine Hydrochloride, the active ingredient in Levomepromazin Neuraxpharm, is a phenothiazine antipsychotic presented as an injectable solution for intramuscular or intravenous use. It is employed to manage schizophrenia, severe agitation, nausea, vomiting and palliative sedation in appropriate patients under medical supervision and careful monitoring.

GNH India supplies Levomepromazin Neuraxpharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide through a robust quality‑assured distribution network. The company adheres to stringent regulatory standards and provides comprehensive technical support to its global partners.

Manufacturer / TM Owner

Neuraxpharm Arzneimittel Gmbh

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Indications & Clinical Uses

  • Levomepromazine is a phenothiazine antipsychotic used in several clinical situations that involve dopamine blockade and related pathways.
  • Schizophrenia: reduces psychotic symptoms and stabilizes mood in patients with chronic disease.
  • Severe agitation: provides rapid calming effect in acute psychiatric emergencies.
  • Nausea and vomiting: controls chemotherapy‑induced or postoperative nausea when other agents are insufficient.
  • Palliative sedation: induces sedation to alleviate refractory distress in end‑of‑life care.

How It Works

  • Levomepromazine exerts its pharmacological activity primarily by antagonizing dopamine D2 receptors, which diminishes dopaminergic neurotransmission linked to psychosis. In addition, it blocks histamine H1, muscarinic acetylcholine, and alpha‑adrenergic receptors, contributing to its sedative, antiemetic, and antihistaminic properties. The combined receptor profile results in reduced psychotic symptoms, decreased nausea, and profound sedation when required.

Side Effects

Levomepromazine may be associated with a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Drowsiness: pronounced sedation and somnolence.
  • Orthostatic hypotension: dizziness upon standing due to vascular blockade.
  • Dry mouth: reduced salivation causing discomfort.
  • Constipation: slowed gastrointestinal motility.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening reaction with fever, rigidity, autonomic instability.
  • Torsades de pointes: rare ventricular arrhythmia linked to QT prolongation.
  • Severe extrapyramidal symptoms: acute dystonia, parkinsonism, or akathisia requiring immediate treatment.

Precautions & Warnings

When prescribing Levomepromazine, clinicians should observe several precautionary measures to minimize risks.

  • Cardiac assessment: obtain baseline ECG due to potential QT‑interval prolongation.
  • Blood pressure monitoring: watch for orthostatic hypotension, especially after dose changes.
  • Hepatic/renal evaluation: consider dose adjustment in patients with organ impairment.
  • Hypersensitivity check: avoid use in individuals with known allergy to phenothiazines.
  • Elderly caution: increased susceptibility to sedation, falls, and anticholinergic effects.
  • Store below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Levomepromazine can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • QT‑prolonging drugs (e.g., macrolide antibiotics, antiarrhythmics) may increase risk of torsades de pointes.
  • CNS depressants (e.g., benzodiazepines, opioids) can cause excessive sedation or respiratory depression.
  • Anticholinergic agents may exacerbate dry mouth and constipation.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) may raise levomepromazine plasma levels.
  • Antihypertensive agents may have additive hypotensive effect.
  • Lithium may increase neurotoxic risk when combined with antipsychotics.

Frequently Asked Questions

Levomepromazin Neuraxpharm contains levomepromazine hydrochloride, a phenothiazine antipsychotic. It is indicated for the treatment of schizophrenia, control of severe agitation, management of nausea and vomiting, and for palliative sedation in end‑of‑life care when other measures are insufficient.

Levomepromazine works by blocking dopamine D2 receptors, which reduces psychotic signaling. It also antagonises histamine H1, muscarinic, and alpha‑adrenergic receptors, providing sedative, antiemetic, and antihistaminic effects that together help control agitation, nausea and facilitate sedation.

The dosage of Levomepromazin Neuraxpharm is individualized. A qualified prescriber determines the appropriate amount, route (intramuscular or intravenous), and frequency based on the patient’s condition, response, and clinical guidelines. No fixed regimen is provided here.

Data on levomepromazine use during pregnancy and lactation are limited. Because potential risks to the fetus or infant cannot be excluded, it should only be used when the expected benefit justifies the possible risk, and after a careful risk‑benefit assessment by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and the necessary import documentation.

Levomepromazine belongs to the phenothiazine class, offering strong dopamine blockade together with antihistaminic and anticholinergic activity. Compared with newer atypical antipsychotics, it may cause more sedation and anticholinergic effects but can be useful when rapid tranquilisation or anti‑emetic action is required.

The product should be stored below 25 °C in its original packaging, protected from light and moisture. Do not freeze. Inspect the vial for particulate matter before use and discard any solution that appears discoloured or contaminated.

Levomepromazin Neuraxpharm is supplied as an injectable solution for intramuscular or intravenous injection. Administration is performed by a qualified healthcare professional, following aseptic technique and the dosage prescribed by the treating physician.

Serious adverse events include neuroleptic malignant syndrome, torsades de pointes due to QT prolongation, and severe extrapyramidal reactions such as acute dystonia or parkinsonism. Prompt recognition and immediate medical intervention are essential if any of these symptoms develop.

Levomepromazine is contraindicated in patients with known hypersensitivity to phenothiazines, in individuals with a history of neuroleptic malignant syndrome, and in patients taking other medications that significantly prolong the QT interval. Caution is also advised for those with severe cardiovascular disease, uncontrolled hypertension, or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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