Product image of Levomepromazin Terapia (Levomepromazine Maleate) supplied by GNH India

Levomepromazin Terapia

Active Ingredient:
Levomepromazine Maleate
Origin:
EU

Levomepromazin Terapia (Levomepromazine Maleate)

Levomepromazine, the active ingredient in Levomepromazin Terapia, is a phenothiazine antipsychotic presented as an oral formulation for oral use. It is employed to manage schizophrenia, acute psychosis, severe agitation, and nausea or vomiting in adult patients.
GNH India supplies Levomepromazin Terapia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Terapia S.A.

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Indications & Clinical Uses

  • Levomepromazine is a phenothiazine antipsychotic that acts on dopaminergic pathways to treat several psychiatric and gastrointestinal conditions.
  • Schizophrenia: reduces psychotic symptoms such as delusions, hallucinations and thought disorder.
  • Acute psychosis: helps control sudden onset of severe psychotic episodes.
  • Severe agitation: calms intense restlessness and aggressive behavior.
  • Nausea and vomiting: alleviates refractory nausea, especially in palliative care settings.

How It Works

  • Levomepromazine exerts its therapeutic effect primarily by antagonising dopamine D2 receptors, thereby diminishing dopaminergic neurotransmission. It also blocks histamine H1, muscarinic acetylcholine, and alpha‑adrenergic receptors, contributing to its sedative, anti‑emetic, and anticholinergic properties while influencing cardiovascular tone and CNS activity.

Side Effects

Levomepromazine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Sedation or drowsiness
  • Orthostatic hypotension
  • Dry mouth and other anticholinergic effects
  • Constipation or gastrointestinal discomfort
  • Blurred vision

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome
  • Tardive dyskinesia or other movement disorders
  • Severe hypotension or cardiac arrhythmia
  • Agranulocytosis or blood dyscrasias
  • Seizures
  • Elevated liver enzymes or hepatic dysfunction

Precautions & Warnings

  • When prescribing Levomepromazin Terapia, clinicians should consider several safety measures.
  • Dose adjustment in elderly: start low and monitor for excessive sedation.
  • Monitor cardiovascular status: risk of orthostatic hypotension and arrhythmia.
  • Assess for extrapyramidal symptoms: watch for tremor, rigidity, or dyskinesia.
  • Avoid use in patients with known hypersensitivity to phenothiazines.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levomepromazin Terapia can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Concurrent use with other dopamine antagonists: increased risk of severe extrapyramidal symptoms.
  • Combination with CNS depressants (e.g., benzodiazepines, opioids): enhanced sedation and respiratory depression.
  • Co‑administration with strong anticholinergic agents: additive anticholinergic burden.

Moderate Interactions (Monitor Closely)

  • Use with antihypertensives: may potentiate hypotensive effect.
  • Combination with QT‑prolonging drugs: increased risk of cardiac arrhythmia.
  • Interaction with CYP2D6 inhibitors: may raise levomepromazine plasma levels.

Frequently Asked Questions

Levomepromazin Terapia contains levomepromazine, a phenothiazine antipsychotic indicated for the treatment of schizophrenia, acute psychotic episodes, severe agitation, and refractory nausea or vomiting, particularly in palliative‑care settings. It helps control psychotic symptoms, calm extreme restlessness, and reduce vomiting when other therapies are insufficient.

Levomepromazine works by blocking dopamine D2 receptors, which reduces dopaminergic activity linked to psychosis. It also antagonises histamine H1, muscarinic, and alpha‑adrenergic receptors, providing sedative, anti‑emetic, and anticholinergic effects while influencing blood pressure and cardiovascular tone.

The specific dose of Levomepromazin Terapia is determined by the prescribing clinician based on the patient’s condition, severity, age, and response to therapy. Dosage may be titrated gradually, and the prescriber will select an appropriate regimen that balances efficacy with safety.

Safety data for levomepromazine in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant. Clinicians typically evaluate each case individually and consider alternative therapies when possible.

To order Levomepromazin Terapia, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Levomepromazine belongs to the phenothiazine class, which is a typical antipsychotic with strong dopamine antagonism and additional antihistamine, anticholinergic and alpha‑blocking properties. Compared with atypical antipsychotics, it may cause more sedation and anticholinergic effects but can be useful for severe agitation and nausea where other agents are less effective.

Levomepromazin Terapia should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid exposing it to extreme temperatures or humidity.

Levomepromazin is administered orally. The tablets or capsules should be swallowed whole with a glass of water, preferably with food or a light snack to reduce gastrointestinal irritation. The exact route and timing are directed by the prescribing healthcare professional.

The most serious risks include neuroleptic malignant syndrome, a potentially life‑threatening reaction characterized by fever, muscle rigidity and autonomic instability; tardive dyskinesia, which may cause irreversible involuntary movements; severe hypotension or cardiac arrhythmias; and rare blood disorders such as agranulocytosis.

Levomepromazin should be avoided in individuals with known hypersensitivity to phenothiazines, those with severe cardiovascular disease prone to orthostatic hypotension, patients with a history of neuroleptic malignant syndrome, and anyone taking medications that could cause dangerous additive effects without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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