Product image of Levomer (Levofloxacin Hemihydrate) supplied by GNH India

Levomer

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Levomer (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Levomer, is a fluoroquinolone presented as an ophthalmic preparation for ocular use. It is employed to treat bacterial eye infections caused by susceptible organisms in adult and pediatric patients. The drug is formulated for topical administration directly onto the eye surface, delivering high local concentrations while minimizing systemic exposure.

GNH India supplies Levomer as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, ophthalmology centres and clinics worldwide.

Manufacturer / TM Owner

Adamed Pharma S.A.

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Indications & Clinical Uses

Levofloxacin is a fluoroquinolone antibacterial used in ophthalmology to treat bacterial infections of the eye.

  • Bacterial conjunctivitis: reduces bacterial load and speeds resolution of redness, discharge and irritation.
  • Bacterial keratitis: eradicates causative pathogens, promoting corneal healing and visual recovery.
  • Blepharitis: diminishes bacterial colonisation of eyelid margins, alleviating inflammation and crusting.
  • Post‑operative prophylaxis: prevents infection after ocular surgery such as cataract extraction.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription and repair. By blocking these targets, it prevents bacterial cell division and leads to rapid, concentration‑dependent bactericidal activity against a broad spectrum of Gram‑positive and Gram‑negative ocular pathogens.

Side Effects

Levofloxacin eye drops may cause local and systemic adverse reactions.

Common Side Effects

  • Eye irritation or burning sensation.
  • Stinging or foreign‑body feeling.
  • Conjunctival hyperemia (redness).
  • Transient blurred vision.
  • Mild tearing.
  • Eyelid edema.

Serious or Rare Side Effects

  • Allergic reactions such as severe eyelid swelling, rash or anaphylaxis.
  • Corneal ulceration or perforation.
  • Tendon rupture or tendonitis (systemic exposure).
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Vision loss due to intra‑ocular inflammation.

Precautions & Warnings

Before prescribing Levomer, consider the following safety measures.

  • Allergy assessment: avoid in patients with known fluoroquinolone hypersensitivity.
  • Corneal integrity: use with caution on compromised corneal epithelium.
  • Concurrent corticosteroids: monitor closely for delayed wound healing or perforation.
  • Systemic exposure: advise patients to report tendon pain or swelling.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levofloxacin ocular formulation can interact with other systemic or ophthalmic agents.

Major Interactions (Avoid)

  • Systemic fluoroquinolones: concurrent use may increase overall fluoroquinolone exposure.
  • Topical corticosteroids: may heighten risk of corneal thinning or perforation.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory eye drops: could affect corneal healing.
  • Other ophthalmic antibiotics: may reduce combined efficacy.
  • Warfarin: systemic absorption could potentiate anticoagulation; monitor INR if long‑term use is anticipated.

Frequently Asked Questions

Levomer contains levofloxacin, a fluoroquinolone antibacterial indicated for the treatment of bacterial eye infections such as conjunctivitis, keratitis, blepharitis, and for prophylaxis after ocular surgery. It works by eliminating susceptible bacteria on the ocular surface.

Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. This blockade stops bacterial cell division, leading to rapid bactericidal activity against a wide range of Gram‑positive and Gram‑negative ocular pathogens.

The dosing regimen for Levomer is determined by the prescribing clinician based on the specific infection, severity, and patient factors. The product is supplied as eye drops and should be administered exactly as directed on the prescription label.

Safety data for ocular levofloxacin in pregnancy and lactation are limited. The prescriber should weigh potential benefits against possible risks and consider alternative treatments when appropriate. Women who are pregnant or nursing should discuss use with their healthcare provider.

To order Levomer, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with older agents such as ciprofloxacin or ofloxacin, levofloxacin offers broader Gram‑negative coverage and a lower propensity for resistance development. It also provides convenient once‑ or twice‑daily dosing schedules, which can improve patient adherence.

Levomer should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and discard any solution that appears discolored or contains particles.

Levomer is applied as eye drops. The prescribed number of drops is placed into the conjunctival sac of the affected eye(s) according to the dosing schedule indicated by the prescriber, typically avoiding contact with the eyelid or lashes to maintain sterility.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, corneal ulceration or perforation, tendon rupture, and systemic hypersensitivity reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience intense eye pain, swelling, or systemic symptoms.

Levomer should not be used by individuals with a known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation. Caution is also advised for patients with pre‑existing corneal epithelial defects or those receiving concurrent topical corticosteroids.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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