Product image of Levomin 20 (Ethinylestradiol, Levonorgestrel) supplied by GNH India

Levomin 20

Active Ingredient:
Ethinylestradiol, Levonorgestrel
Origin:
EU

Levomin 20 (Ethinylestradiol, Levonorgestrel)

Ethinylestradiol, the active ingredient in Levomin 20, is a combined oral contraceptive presented as a tablet for oral use. Together with levonorgestrel, it provides hormonal contraception to prevent pregnancy in women of reproductive age by suppressing ovulation and modifying cervical mucus and the endometrial lining.

GNH India supplies Levomin 20 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company follows stringent quality standards and provides regulatory‑approved batches to meet global demand for reliable oral contraceptive tablets.

Manufacturer / TM Owner

Mibe Gmbh Arzneimittel

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Indications & Clinical Uses

Levomin 20, a combined oral contraceptive, is indicated for hormonal contraception to prevent pregnancy.

  • Prevention of pregnancy: provides reliable contraceptive protection when taken as prescribed.
  • Regulation of menstrual cycle: helps achieve more predictable bleeding patterns and reduces menstrual irregularities.
  • Treatment of moderate acne: hormonal control can improve acne symptoms in some women.

How It Works

  • Ethinylestradiol binds to estrogen receptors while levonorgestrel binds to progesterone receptors, together suppressing the hypothalamic‑pituitary‑gonadal axis. This inhibition reduces the secretion of luteinizing hormone and follicle‑stimulating hormone, preventing follicular development and ovulation. The progestogenic component also thickens cervical mucus and induces endometrial changes that are unfavorable for implantation, thereby providing contraceptive efficacy. Additionally, the estrogen component stabilizes the endometrial lining, reducing breakthrough bleeding.

Side Effects

Levomin 20 may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Nausea: mild stomach upset that often resolves with continued use.
  • Headache: tension‑type or migraine‑like pain.
  • Breast tenderness: temporary swelling or discomfort.
  • Spotting between periods: light vaginal bleeding.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins, potentially life‑threatening.
  • Stroke or myocardial infarction: rare cardiovascular events.
  • Severe allergic reaction: rash, swelling, or anaphylaxis requiring immediate care.

Precautions & Warnings

Before prescribing Levomin 20, clinicians should evaluate the following precautions to ensure safe use.

  • Contraindications: known thrombophilia, estrogen‑dependent tumor, active liver disease, or current pregnancy.
  • Smoking: avoid use in women over 35 who smoke due to increased cardiovascular risk.
  • Cardiovascular history: assess for hypertension, stroke, or coronary artery disease before initiation.
  • Drug interactions: review concomitant medications that may alter hormone levels or efficacy.
  • Store at ambient temperature: keep below 25°C, retain original packaging, and protect from moisture.

Avoid Interactions

Levomin 20 can interact with other medicines, affecting its effectiveness or safety.

Major Interactions (Avoid)

  • Potent enzyme inducers (e.g., rifampin, carbamazepine, phenytoin): may markedly reduce contraceptive efficacy.
  • Hormonal therapies for breast cancer: combined use is contraindicated due to opposing mechanisms.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles (ketoconazole, itraconazole): can increase hormone concentrations, requiring clinical observation.
  • Certain antibiotics (tetracycline, metronidazole): may slightly lower effectiveness; advise backup contraception.
  • St. John’s wort: herbal supplement that may decrease plasma hormone levels, reducing protection.

Frequently Asked Questions

Levomin 20 is a combined oral contraceptive indicated for the prevention of pregnancy. The tablet delivers a fixed dose of ethynylestradiol and levonorgestrel to suppress ovulation, thicken cervical mucus, and alter the endometrial lining, providing reliable contraceptive protection when taken as directed.

Ethinylestradiol acts as a synthetic estrogen, while levonorgestrel is a synthetic progestogen. Together they inhibit the hypothalamic‑pituitary‑gonadal axis, reducing luteinizing hormone and follicle‑stimulating hormone release, which prevents follicular development and ovulation. The progestogen also thickens cervical mucus and creates an endometrial environment that is unsuitable for implantation.

The specific dosing regimen for Levomin 20 is determined by the prescribing healthcare professional. Typically, combined oral contraceptives are taken as one tablet daily at the same time each day, but the exact schedule and any missed‑dose instructions should be provided by the prescriber.

Levomin 20 is contraindicated during pregnancy because it is intended to prevent conception, not to treat an existing pregnancy. Women who become pregnant should discontinue use immediately. While limited data exist for breastfeeding, combined oral contraceptives are generally considered compatible, but a clinician should evaluate individual risk‑benefit factors.

To place an order, submit an enquiry on the Levomin 20 product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

Levomin 20 contains a standard dose of ethynylestradiol combined with levonorgestrel, a widely used progestogen. Compared with other formulations, it offers a familiar safety profile and efficacy. Differences among products usually relate to the estrogen dose, the type of progestogen, and any additional indications such as acne control; clinicians select based on individual patient needs.

Levomin 20 tablets should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original blister pack or container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use. Do not store in the refrigerator or freezer.

Levomin 20 is taken orally as a single tablet each day, preferably at the same time each day. The tablet is swallowed whole with water and should be taken with or without food according to the prescriber’s instructions. Consistent daily intake maintains hormone levels needed for effective contraception.

Serious but rare risks include venous thromboembolism, stroke, myocardial infarction, and severe allergic reactions such as anaphylaxis. These events are more likely in women with pre‑existing cardiovascular risk factors, smoking history, or certain genetic clotting disorders. Prompt medical attention is required if symptoms such as sudden leg pain, chest discomfort, or severe rash occur.

Levomin 20 should not be used by women who are pregnant, have a known history of thromboembolic disorders, estrogen‑dependent tumors, uncontrolled hypertension, active liver disease, or who are over 35 and smoke. Additionally, individuals taking contraindicated medications or with known hypersensitivity to any component of the tablet should avoid its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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