Product image of Levomine (Ethinylestradiol, Levonorgestrel) supplied by GNH India

Levomine

Active Ingredient:
Ethinylestradiol, Levonorgestrel
Origin:
EU

Levomine (Ethinylestradiol, Levonorgestrel)

Ethinylestradiol and Levonorgestrel, the active ingredients in Levomine, are a combined oral contraceptive presented as tablets for oral use. The formulation prevents pregnancy by suppressing ovulation and altering cervical mucus in women of reproductive age. It belongs to the hormonal contraceptive drug class and is regulated as a prescription medication in the European Union.

GNH India supplies Levomine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sun-Farm Sp. Z.O.O.

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Indications & Clinical Uses

Levomine, a combined oral contraceptive, works within the hormonal regulation pathway of the menstrual cycle to prevent pregnancy.

  • Prevention of pregnancy: inhibits ovulation and creates cervical mucus that blocks sperm entry.
  • Contraception: provides reliable, reversible birth control for women of reproductive age.

How It Works

  • Levomine combines ethinylestradiol, a synthetic estrogen, with levonorgestrel, a progestin. The estrogen suppresses the mid‑cycle surge of luteinizing hormone, while the progestin blocks the luteinizing hormone surge and prevents follicular development. Together they inhibit ovulation, thicken cervical mucus to impede sperm penetration, and induce endometrial changes that reduce the likelihood of implantation.

Side Effects

Levomine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Breast tenderness: discomfort or swelling of the breasts.
  • Headache: transient cranial pain.
  • Spotting or breakthrough bleeding: irregular uterine bleeding.
  • Weight gain: modest increase in body weight.
  • Mood changes: irritability or emotional fluctuations.

Serious or Rare Side Effects

  • Venous thromboembolism: deep vein thrombosis or pulmonary embolism.
  • Hypertension: significant increase in blood pressure.
  • Liver disorders: jaundice or hepatic dysfunction.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Visual disturbances: blurred vision or eye pain.

Precautions & Warnings

Before prescribing Levomine, clinicians should evaluate several safety considerations.

  • Contraindications: avoid in women with a history of thromboembolic events, estrogen‑dependent tumors, or active liver disease.
  • Pregnancy: contraindicated; ensure patient is not pregnant before initiating therapy.
  • Smoking: assess smoking status, especially in women over 35, as risk of cardiovascular events increases.
  • Blood pressure: monitor regularly; discontinue if hypertension develops.
  • Drug interactions: review concomitant medications that may reduce efficacy or increase risk.
  • Store at ambient temperature: keep tablets in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levomine can interact with other medicines, affecting its effectiveness or safety.

Major Interactions (Avoid)

  • Enzyme inducers (e.g., rifampicin, carbamazepine, phenytoin): markedly reduce hormone levels, compromising contraceptive efficacy.
  • St. John’s Wort: herbal inducer that may lower plasma concentrations of ethinylestradiol and levonorgestrel.
  • Certain antiretrovirals (e.g., efavirenz): decrease hormonal exposure, increasing risk of unintended pregnancy.

Moderate Interactions (Monitor Closely)

  • Antifungal agents (e.g., ketoconazole): may increase hormone levels, raising risk of side effects.
  • Diuretics (e.g., thiazides): can elevate blood pressure when combined with estrogen.
  • Anticonvulsants (e.g., valproate): may alter hormone metabolism, requiring clinical monitoring.

Frequently Asked Questions

Levomine is a combined oral contraceptive containing ethinylestradiol and levonorgestrel. It is prescribed to prevent pregnancy in women of reproductive age by inhibiting ovulation and creating cervical mucus that hinders sperm. It also provides a reliable, reversible method of hormonal contraception.

Ethinylestradiol is a synthetic estrogen that suppresses the mid‑cycle surge of luteinizing hormone, while levonorgestrel is a progestin that blocks the luteinizing hormone surge and prevents follicular development. Together they stop ovulation, thicken cervical mucus, and alter the endometrium, making implantation unlikely.

The dosage of Levomine is determined by the prescribing clinician based on the product’s labeling and the patient’s individual needs. Typically, the medication is taken once daily at the same time for a 21‑day active phase followed by a hormone‑free interval, but the exact regimen must be confirmed by a qualified health professional.

Levomine is contraindicated during pregnancy because its hormonal components can affect fetal development. Women who become pregnant while taking the product should discontinue use immediately. Breastfeeding is not recommended while on combined oral contraceptives, as the hormones may pass into breast milk and affect the infant; alternative methods should be considered.

To place an order, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Levomine contains a standard dose of ethinylestradiol paired with levonorgestrel, a widely used progestin. Compared with formulations that use newer progestins, Levomine offers a well‑characterized safety profile and reliable contraceptive efficacy. Choice of product often depends on individual risk factors, tolerability, and physician preference.

Levomine tablets should be stored at ambient temperature, below 25 °C, in their original blister pack to protect them from moisture and light. Keep the medication out of reach of children and do not use if the packaging is damaged or the tablets appear discolored.

Levomine is taken orally, usually as one tablet each day, at the same time each day. The typical regimen includes 21 consecutive days of active tablets followed by a 7‑day hormone‑free interval, during which withdrawal bleeding occurs. Patients should follow the specific instructions provided by their healthcare provider.

The most serious risks include venous thromboembolism such as deep‑vein thrombosis or pulmonary embolism, arterial thrombosis leading to stroke or myocardial infarction, and severe hypertension. Women with a history of clotting disorders, smoking, or certain cardiovascular conditions should avoid Levomine and discuss alternatives with their clinician.

Levomine is contraindicated in women who are pregnant, have known or suspected estrogen‑dependent tumors, a history of thromboembolic disease, uncontrolled hypertension, active liver disease, or who are breastfeeding. It should also be avoided in individuals with known hypersensitivity to ethinylestradiol, levonorgestrel, or any tablet excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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