Product image of Levonic (Levofloxacin) supplied by GNH India

Levonic

Active Ingredient:
Levofloxacin
Origin:
EU

Levonic (Levofloxacin)

Levofloxacin, the active ingredient in Levonic, is a fluoroquinolone presented as an intravenous solution for IV use. It treats a range of serious bacterial infections in adult patients, including community‑acquired pneumonia, complicated urinary tract infections, skin and soft tissue infections, intra‑abdominal infections, and bacterial sinusitis.

GNH India supplies Levonic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and research institutions worldwide, ensuring quality and regulatory compliance across global markets, with a focus on timely delivery, cold‑chain logistics where required, and comprehensive documentation for import and distribution.

Manufacturer / TM Owner

Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.

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Indications & Clinical Uses

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections in various organ systems.

  • Community‑acquired pneumonia: effective bacterial eradication leading to clinical recovery.
  • Complicated urinary tract infections: eradicates resistant uropathogens and resolves infection.
  • Skin and soft tissue infections: clears bacterial involvement and promotes wound healing.
  • Intra‑abdominal infections: eliminates polymicrobial infection sources.
  • Bacterial sinusitis: resolves sinus inflammation caused by susceptible bacteria.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By blocking these targets, it prevents bacterial DNA synthesis and transcription, leading to bacterial cell death and eradication of the infection.

Side Effects

Levofloxacin may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Rash: mild skin erythema or itching.

Serious or Rare Side Effects

  • Tendon rupture: especially Achilles tendon, requiring immediate medical attention.
  • QT interval prolongation: may precipitate cardiac arrhythmias.
  • Clostridioides difficile infection: severe colitis with watery diarrhea.
  • Severe allergic reactions: anaphylaxis, angioedema, or Stevens‑Johnson syndrome.
  • Hepatic toxicity: elevated liver enzymes or jaundice.

Precautions & Warnings

Levofloxacin requires careful consideration of patient‑specific factors.

  • Renal impairment: dose adjustment may be required to avoid accumulation.
  • History of tendon disorders: avoid use due to increased risk of tendon rupture.
  • QT prolongation risk: monitor ECG in patients with cardiac history.
  • Pregnancy Category C: use only if potential benefits justify potential fetal risks.
  • Concomitant drugs: assess for interactions that may increase toxicity.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Levofloxacin can interact with several medicines, altering safety or efficacy.

Major Interactions (Avoid)

  • NSAIDs: co‑administration may increase risk of central nervous system toxicity.
  • QT‑prolonging agents (e.g., quinidine, macrolides): may cause serious arrhythmias.
  • Systemic corticosteroids: combined use raises tendon rupture risk.

Moderate Interactions (Monitor Closely)

  • Antacids containing magnesium or aluminum: may reduce levofloxacin absorption.
  • Warfarin: concurrent use can enhance anticoagulant effect, requiring INR monitoring.
  • Theophylline: levofloxacin may increase theophylline plasma levels, necessitating dose adjustment.

Frequently Asked Questions

Levonics contains levofloxacin, a fluoroquinolone antibiotic indicated for serious bacterial infections such as community‑acquired pneumonia, complicated urinary tract infections, skin and soft tissue infections, intra‑abdominal infections, and bacterial sinusitis. The specific infection treated is determined by the prescribing clinician based on culture results and clinical presentation.

Levofloxacin inhibits two essential bacterial enzymes, DNA gyrase and topoisomerase IV. These enzymes are required for DNA supercoiling and replication. By blocking their activity, levofloxacin prevents bacterial DNA synthesis, leading to bacterial cell death and clearance of the infection.

The dosage of Levonic is individualized by the prescriber according to the type and severity of infection, patient weight, renal function, and other clinical factors. Only a qualified healthcare professional can determine the appropriate dose and duration for each patient.

Levonics is classified as Pregnancy Category C, meaning it should be used only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk, so breastfeeding mothers should discuss risks and benefits with their healthcare provider before using the product.

To request Levonic, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where applicable) and necessary import documentation.

Levonics (levofloxacin) offers a broad spectrum of activity against Gram‑negative and Gram‑positive bacteria and is often preferred for its once‑daily dosing and high bioavailability compared with older fluoroquinolones such as ciprofloxacin. However, choice of therapy depends on local resistance patterns, patient factors, and specific infection site.

Levonics should be stored at 2‑8 °C (refrigerated). Keep the vial in its original packaging, protect it from light, and do not freeze or shake the solution. Proper storage maintains drug stability and potency until administration.

Levonics is supplied as an intravenous solution and is administered by a qualified healthcare professional via slow IV infusion. The infusion rate and duration are determined by the prescribing clinician based on the infection being treated and patient tolerance.

Serious adverse events include tendon rupture (especially Achilles tendon), QT interval prolongation leading to potentially life‑threatening arrhythmias, severe allergic reactions such as anaphylaxis, and Clostridioides difficile‑associated colitis. Patients should be monitored closely for any signs of these conditions.

Levonics is contraindicated in patients with a known hypersensitivity to levofloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, and patients taking other medications that significantly prolong the QT interval. Clinicians must assess each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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