Product image of Levonic (Levofloxacin) supplied by GNH India

Levonic

Active Ingredient:
Levofloxacin
Origin:
EU

Levonic (Levofloxacin)

Levofloxacin, the active ingredient in Levonic, is a fluoroquinolone presented as an intravenous solution for parenteral use. It treats a range of bacterial infections in adults and children as prescribed by a healthcare professional.

GNH India supplies Levonic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, transplant centres, oncology centres and clinics worldwide.

Manufacturer / TM Owner

Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.

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Indications & Clinical Uses

Levofloxacin is a broad‑spectrum antibacterial used for infections caused by susceptible bacteria.

  • Community‑acquired pneumonia: eradicates typical and atypical pathogens, improving respiratory function.
  • Complicated urinary tract infection: eliminates Gram‑negative organisms, facilitating urinary tract recovery.
  • Intra‑abdominal infection: targets mixed flora, supporting resolution of peritoneal inflammation.
  • Skin and soft‑tissue infection: reduces bacterial load, aiding wound healing.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By stabilizing the enzyme‑DNA complex, it prevents the resealing of DNA strands, leading to bacterial cell death and a bactericidal effect against a wide range of Gram‑positive and Gram‑negative organisms.

Side Effects

Levofloxacin may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Insomnia: difficulty falling or staying asleep.
  • Rash: mild skin erythema.

Serious or Rare Side Effects

  • Tendon rupture: sudden tendon pain or loss of function.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Clostridioides difficile infection: severe colitis symptoms.
  • Severe allergic reaction: anaphylaxis, swelling, or breathing difficulty.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Peripheral neuropathy: tingling or numbness in extremities.

Precautions & Warnings

Levofloxacin requires careful consideration of patient‑specific factors before use.

  • Renal impairment: dose adjustment may be required based on creatinine clearance.
  • History of tendon disorders: avoid use or monitor closely for tendon pain.
  • QT prolongation risk: obtain baseline ECG and monitor cardiac rhythm.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Concomitant CNS‑active drugs: monitor for seizures or heightened stimulation.
  • Store at below 25°C: keep in original packaging, protect from moisture and light.

Avoid Interactions

Levofloxacin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Ciprofloxacin: additive QT‑prolongation risk.
  • NSAIDs (e.g., ibuprofen): increased central nervous system stimulation.
  • Theophylline: elevated serum theophylline levels, risk of toxicity.
  • Warfarin: enhanced anticoagulant effect, monitor INR closely.

Moderate Interactions (Monitor Closely)

  • Antacids containing magnesium or aluminum: reduce levofloxacin absorption; separate dosing by at least 2 hours.
  • Corticosteroids: heightened risk of tendon rupture.
  • Diabetes medications (e.g., insulin, sulfonylureas): possible dysglycemia; monitor blood glucose.

Frequently Asked Questions

Levonic, containing levofloxacin, is indicated for a variety of bacterial infections such as community‑acquired pneumonia, complicated urinary tract infections, intra‑abdominal infections, and skin and soft‑tissue infections. It is prescribed when the causative bacteria are susceptible to fluoroquinolones.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. This inhibition prevents the bacteria from repairing their DNA, leading to bacterial cell death and a bactericidal effect.

The dose of Levonic is determined by the prescribing clinician based on the type and severity of infection, patient weight, renal function, and other clinical factors. Dosage regimens are individualized and should follow the prescriber’s instructions.

Levofloxacin is classified as a pregnancy‑category drug where safety data are limited. It should only be used during pregnancy or lactation if the potential benefits justify the potential risks to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To order Levonic, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Levonic (levofloxacin) offers a broad spectrum of activity against both Gram‑positive and Gram‑negative bacteria and has a once‑daily dosing option for many infections, which can improve adherence compared with some older fluoroquinolones that require multiple daily doses.

Levonic should be stored at temperatures below 25 °C, in its original container, protected from moisture and direct light. Maintaining these conditions helps preserve the stability and potency of the intravenous solution.

Levonic is administered intravenously by a healthcare professional. The infusion rate and duration are determined by the prescriber and should follow institutional protocols to ensure safe delivery of the medication.

Serious risks include tendon rupture, QT‑interval prolongation leading to arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated diarrhea, and hepatic dysfunction. Patients should be monitored for these events, especially if they have pre‑existing risk factors.

Levonic is contraindicated in patients with a known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation. It should also be avoided in individuals with a history of tendon disorders related to fluoroquinolone use or those with significant QT prolongation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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