Product image of Levonic (Levofloxacin) supplied by GNH India

Levonic

Active Ingredient:
Levofloxacin
Origin:
EU

Levonic (Levofloxacin)

Levofloxacin, the active ingredient in Levonic, is a Fluoroquinolone antibiotic presented as an injection for intravenous use. It treats a range of serious bacterial infections in adult patients.
GNH India supplies Levonic as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.

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Indications & Clinical Uses

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections affecting various organ systems.

  • Community‑acquired pneumonia: effective bacterial eradication improving respiratory outcomes.
  • Hospital‑acquired pneumonia: rapid pathogen clearance in severe nosocomial cases.
  • Complicated urinary tract infections: resolves infection when oral therapy is insufficient.
  • Complicated skin and soft‑tissue infections: eliminates resistant Gram‑negative organisms.
  • Intra‑abdominal infections: provides broad‑spectrum coverage for mixed flora.
  • Severe sepsis: contributes to systemic infection control in critical care.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and supercoiling. By blocking these targets, the drug prevents bacterial DNA synthesis, leading to bactericidal activity against a wide range of Gram‑negative and Gram‑positive pathogens.

Side Effects

Levofloxacin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Dizziness
  • Rash
  • Photosensitivity

Serious or Rare Side Effects

  • Tendon rupture or tendinitis
  • QT interval prolongation
  • Clostridioides difficile‑associated diarrhea
  • Peripheral neuropathy
  • Severe allergic reactions (anaphylaxis)
  • Hepatic dysfunction

Precautions & Warnings

Levofloxacin requires careful consideration of patient‑specific factors before use.

  • Renal impairment: adjust dose based on renal function.
  • History of tendon disorders: avoid use due to heightened risk of tendon rupture.
  • QT prolongation risk: monitor ECG in patients with cardiac history.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Concomitant CNS‑active drugs: monitor for seizures.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levofloxacin can interact with several medicines, necessitating monitoring or avoidance.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect; monitor INR closely.
  • Corticosteroids: heightened risk of tendon rupture.

Moderate Interactions (Monitor Closely)

  • Theophylline: may raise plasma levels, watch for toxicity.
  • Cyclosporine: possible increase in levofloxacin concentrations.
  • Sulfonylureas (diabetes meds): may enhance hypoglycemic effect.

Frequently Asked Questions

Levonics contains levofloxacin, a fluoroquinolone antibiotic indicated for serious bacterial infections such as community‑acquired and hospital‑acquired pneumonia, complicated urinary tract infections, complicated skin and soft‑tissue infections, intra‑abdominal infections, and severe sepsis in adult patients.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. Inhibiting these targets prevents bacterial DNA synthesis, leading to rapid bactericidal activity against a broad spectrum of Gram‑negative and Gram‑positive organisms.

The specific dose of Levonic is determined by the prescribing clinician based on the infection type, severity, patient weight, renal function, and other clinical factors. No fixed regimen is provided here; the prescriber sets the appropriate dosing schedule.

Safety data for levofloxacin in pregnancy and lactation are limited. Use is generally reserved for situations where the potential benefit to the mother outweighs any possible risk to the fetus or infant, and only under medical supervision.

To order Levonic, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and required import documentation.

Levonics (levofloxacin) offers once‑daily dosing and a broad spectrum that includes many Gram‑negative and Gram‑positive pathogens, similar to moxifloxacin but with a slightly different activity profile against anaerobes. Choice between agents depends on local resistance patterns, infection site, and patient‑specific factors.

Levonics should be stored at 2–8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging to maintain stability and ensure the cold‑chain is maintained during transport and storage.

Levonics is supplied as a sterile injection for intravenous administration. It is typically infused over a prescribed period, often 30–60 minutes, under aseptic conditions by qualified healthcare personnel.

The most serious adverse events include tendon rupture or tendinitis, QT‑interval prolongation leading to arrhythmias, Clostridioides difficile‑associated colitis, severe allergic reactions such as anaphylaxis, peripheral neuropathy, and hepatic dysfunction. Prompt medical attention is required if any of these occur.

Levonics is contraindicated in patients with known hypersensitivity to levofloxacin or other fluoroquinolones, a history of tendon disorders related to fluoroquinolone use, significant QT prolongation, or those receiving concomitant medications that markedly increase tendon‑rupture risk. Caution is also advised for patients with severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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