Product image of Levonic-Opto (Levofloxacin) supplied by GNH India

Levonic-Opto

Active Ingredient:
Levofloxacin
Origin:
EU

Levonic-Opto (Levofloxacin)

Levofloxacin, the active ingredient in Levonic-Opto, is a fluoroquinolone antibiotic presented as an ophthalmic solution for ocular use. It treats bacterial eye infections such as bacterial conjunctivitis, keratitis, and other bacterial eye infections.

GNH India supplies Levonic-Opto as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.

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Indications & Clinical Uses

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections of the eye.

  • Bacterial conjunctivitis: reduces bacterial load and resolves redness, discharge and irritation.
  • Keratitis: eradicates causative bacteria and promotes corneal healing.
  • Other bacterial eye infections: treats infections such as blepharitis or corneal ulceration caused by susceptible organisms.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. By binding to these enzymes, it prevents bacterial DNA supercoiling and separation, leading to inhibition of bacterial cell division and ultimately bacterial death. The drug is bactericidal against a broad range of Gram‑positive and Gram‑negative ocular pathogens.

Side Effects

Levofloxacin may cause ocular and systemic adverse reactions.

Common Side Effects

  • Eye irritation or burning on instillation.
  • Redness of the conjunctiva.
  • Temporary blurred vision.
  • Tearing or excessive lacrimation.
  • Mild headache.
  • Nausea (rare with ocular use).

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis, angioedema).
  • Tendon rupture or tendonitis, especially in patients with systemic exposure.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Corneal ulceration or perforation.
  • Vision loss due to optic neuritis.
  • Systemic QT prolongation in susceptible individuals.

Precautions & Warnings

Before using Levonic-Opto, consider the following precautions.

  • Pregnancy: safety not established; avoid unless benefits outweigh risks.
  • Breastfeeding: unknown excretion; consider potential risk to infant.
  • Renal impairment: dose adjustment may be required based on prescriber assessment.
  • Hypersensitivity: discontinue immediately if allergic reaction occurs.
  • Contact lens wearers: avoid use while wearing lenses; remove lenses before instillation.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Levofloxacin can interact with other medicines; monitor accordingly.

Major Interactions (Avoid)

  • Systemic fluoroquinolones: concurrent use may increase risk of tendon rupture.
  • Antacids containing aluminum or magnesium: may reduce ocular absorption.
  • Corticosteroids: may increase risk of secondary ocular infections.

Moderate Interactions (Monitor Closely)

  • Warfarin: levofloxacin may enhance anticoagulant effect, requiring INR monitoring.
  • Theophylline: may increase plasma theophylline concentrations.
  • NSAIDs (topical): may raise risk of corneal toxicity when used together.

Frequently Asked Questions

Levonics-Opto is indicated for bacterial eye infections, including bacterial conjunctivitis, keratitis, and other bacterial ocular conditions such as blepharitis or corneal ulceration caused by susceptible microorganisms.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. This inhibition stops bacterial cell division, leading to rapid bactericidal activity against a broad spectrum of ocular pathogens.

The dosing regimen for Levonic-Opto is determined by the prescribing ophthalmologist based on the severity of the infection, the specific pathogen, and patient factors. The prescriber will provide exact instructions for frequency and duration of use.

Safety data for Levonic-Opto in pregnancy and lactation are limited. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by the treating physician.

To order Levonic-Opto, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Levonics-Opto belongs to the fluoroquinolone class, offering broad‑spectrum coverage against many Gram‑positive and Gram‑negative bacteria. Compared with older agents such as chloramphenicol or polymyxin‑B/trimethoprim, levofloxacin often provides faster bacterial eradication and a lower risk of resistance development, though individual choice depends on susceptibility patterns and patient tolerance.

Levonics-Opto should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from direct light and moisture, and discard any solution that appears discolored or contains particles.

Levonics-Opto is applied topically to the eye as directed by the prescriber. Typically, a few drops are instilled into the affected eye(s) at the prescribed frequency, with hands washed beforehand and contact lenses removed before administration.

Serious adverse events include severe allergic reactions (anaphylaxis, angioedema), tendon rupture, Stevens‑Johnson syndrome, toxic epidermal necrolysis, corneal ulceration or perforation, and systemic QT‑interval prolongation. Patients should seek immediate medical attention if they experience symptoms such as swelling, rash, vision changes, or severe pain.

Levonics-Opto should be avoided in individuals with known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation. Caution is also advised for patients with a history of tendon disorders, uncontrolled epilepsy, or those receiving concurrent systemic fluoroquinolones.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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