Product image of Levonicopto (Levofloxacin) supplied by GNH India

Levonicopto

Active Ingredient:
Levofloxacin
Origin:
EU

Levonicopto (Levofloxacin)

Levofloxacin, the active ingredient in Levonicopto, is a fluoroquinolone antibiotic presented as an ophthalmic solution for ocular use. It treats bacterial conjunctivitis, bacterial keratitis and other ocular bacterial infections in patients requiring topical eye therapy.

GNH India supplies Levonicopto as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.

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Indications & Clinical Uses

Levonicopto is a fluoroquinolone eye drop indicated for bacterial infections of the eye surface and cornea.

  • Bacterial conjunctivitis: reduces bacterial load and accelerates resolution of redness and discharge.
  • Bacterial keratitis: eradicates causative organisms and promotes corneal healing.
  • Other ocular bacterial infections: provides broad‑spectrum coverage for Gram‑negative and Gram‑positive pathogens affecting the eye.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By stabilizing the DNA‑enzyme complex, it prevents bacterial chromosome segregation, leading to bactericidal activity against a wide range of ocular pathogens.

Side Effects

Levonicopto may cause local ocular reactions and, rarely, systemic hypersensitivity.

Common Side Effects

  • Stinging or burning sensation upon instillation.
  • Redness of the conjunctiva.
  • Transient blurred vision.
  • Foreign‑body sensation.
  • Mild itching or irritation.
  • Increased tearing.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angioedema, anaphylaxis).
  • Corneal ulceration or perforation.
  • Significant visual loss.
  • Persistent eye pain or swelling.
  • Stevens‑Johnson syndrome involving the eye.
  • Toxic epidermal necrolysis affecting ocular tissues.

Precautions & Warnings

Before prescribing Levonicopto, consider the following safety measures.

  • Pregnancy: safety not established; use only if clearly needed.
  • Breastfeeding: unknown excretion; weigh benefits against potential risks.
  • Contact lens wearers: remove lenses before and for at least 15 minutes after instillation.
  • Concurrent ocular surgery: avoid use immediately before or after procedures unless directed.
  • Known fluoroquinolone allergy: contraindicated.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Levonicopto may interact with systemic or topical agents; monitor patients accordingly.

Major Interactions (Avoid)

  • Systemic fluoroquinolones: additive risk of tendon rupture and QT prolongation.
  • Live vaccines: may diminish vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • Anticholinergic eye drops: may reduce drug absorption.
  • Topical corticosteroids: increased risk of secondary infection.
  • Non‑steroidal anti‑inflammatory eye drops: may affect corneal healing.
  • Other ophthalmic antibiotics: potential for antagonism or reduced efficacy.

Frequently Asked Questions

Levonicopto is a prescription ophthalmic solution containing levofloxacin. It is indicated for the treatment of bacterial conjunctivitis, bacterial keratitis, and other bacterial infections of the eye, providing broad‑spectrum activity against common ocular pathogens.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. This inhibition halts bacterial cell division and leads to bacterial death, offering bactericidal activity against a wide range of Gram‑positive and Gram‑negative organisms.

The dosing regimen for Levonicopto is determined by the prescribing clinician based on the infection severity, patient age, and response to therapy. The prescriber will specify the number of drops, frequency, and duration appropriate for each indication.

Safety data for Levonicopto in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To order Levonicopto, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levonicopto (levofloxacin) offers a broader spectrum and higher potency against many resistant strains compared with older agents such as ciprofloxacin. Compared with moxifloxacin, it has similar efficacy but a slightly different safety profile, allowing clinicians to choose based on pathogen susceptibility and patient tolerance.

Levonicopto should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from light and moisture, and discard any solution that appears discolored or contains particles.

Levonicopto is applied as eye drops. The patient should wash hands, tilt the head back, pull down the lower eyelid, instill the prescribed number of drops, and close the eye gently for a few seconds. Contact lenses should be removed before administration and re‑inserted after the recommended interval.

Serious adverse reactions include severe allergic responses such as angioedema or anaphylaxis, corneal ulceration or perforation, and significant visual loss. Patients should seek immediate medical attention if they experience intense eye pain, swelling, rapid vision changes, or signs of a systemic allergic reaction.

Levonicopto is contraindicated in individuals with a known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation. It should also be avoided in patients with a history of tendon disorders related to fluoroquinolone use, unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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