Product image of Levonis Bambini (Flunisolide) supplied by GNH India

Levonis Bambini

Active Ingredient:
Flunisolide
Origin:
EU

Levonis Bambini (Flunisolide)

Flunisolide, the active ingredient in Levonis Bambini, is a corticosteroid presented as an inhalation formulation for inhalation use. It is employed to treat inflammatory airway conditions, primarily asthma, by reducing airway swelling and hyper‑responsiveness and improving overall lung function.

GNH India supplies Levonis Bambini as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance, and reliable logistics for global distribution. Our network facilitates timely delivery across Europe, Asia, Africa and the Americas, backed by robust quality‑assurance processes.

Manufacturer / TM Owner

Farto S.R.L. Farmaco Biochimico Toscano

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Indications & Clinical Uses

Flunisolide, an inhaled corticosteroid, acts on airway inflammation in asthma.

  • Asthma (mild persistent): improves daily symptom control and reduces need for rescue inhaler.
  • Asthma (moderate persistent): decreases frequency of exacerbations and hospital visits.
  • Asthma (severe persistent): contributes to long‑term lung function preservation when used as maintenance therapy.

How It Works

  • Flunisolide binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This interaction suppresses the expression of pro‑inflammatory cytokines, chemokines, and adhesion molecules, leading to reduced airway edema, mucus production, and bronchial hyper‑reactivity.

Side Effects

Common Side Effects

  • Oral candidiasis (thrush) due to local immunosuppression.
  • Hoarseness or voice changes.
  • Cough or throat irritation after inhalation.
  • Mild headache.
  • Nausea.
  • Upper respiratory tract infection.

Serious or Rare Side Effects

  • Adrenal suppression with systemic effects.
  • Growth retardation in children with prolonged use.
  • Severe allergic reactions, including anaphylaxis.
  • Pneumonia or other serious respiratory infections.
  • Cataracts or glaucoma with long‑term therapy.
  • Paradoxical bronchospasm.

Precautions & Warnings

Before initiating therapy, assess asthma control and educate patients on proper inhaler technique.

  • Monitor for oral thrush: advise rinsing mouth after each dose.
  • Use a spacer device to minimize oropharyngeal deposition.
  • Avoid abrupt discontinuation; taper if long‑term high doses are used.
  • Caution in patients with active tuberculosis or untreated infections.
  • Pregnancy and breastfeeding: consult a healthcare professional before use.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Flunisolide may interact with several medications that affect corticosteroid activity or immune response.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin): may reduce inhaled steroid efficacy.
  • Systemic corticosteroids: increase risk of systemic side effects.
  • Live vaccines: may suppress vaccine‑induced immunity.

Moderate Interactions (Monitor Closely)

  • Short‑acting β2‑agonists: may mask worsening asthma symptoms.
  • Antifungal agents (e.g., ketoconazole): may increase local exposure.
  • Diuretics: potential electrolyte disturbances.
  • Anticholinergics: additive bronchodilatory effects.

Frequently Asked Questions

Levonis Bambini contains flunisolide, an inhaled corticosteroid indicated for the maintenance treatment of asthma. It helps control chronic airway inflammation, reduces the frequency of asthma symptoms, and lowers the risk of exacerbations when used regularly as prescribed by a healthcare professional.

Flunisolide binds to glucocorticoid receptors inside airway cells, altering gene transcription. This suppresses the production of inflammatory mediators such as cytokines and chemokines, leading to decreased airway swelling, mucus formation, and hyper‑responsiveness, thereby improving breathing in asthma patients.

The dose of Levonis Bambini is individualized by the prescribing clinician based on the patient’s age, severity of asthma, and response to therapy. The prescriber determines the number of inhalations per day and any necessary adjustments, following current asthma management guidelines.

Safety data for flunisolide during pregnancy and lactation are limited. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Levonis Bambini.

To order Levonis Bambini, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Levonis Bambini (flunisolide) is comparable to other inhaled corticosteroids such as budesonide or beclomethasone in its anti‑inflammatory potency. Choice among agents often depends on device preference, dosing frequency, patient tolerance, and specific regulatory approvals in a given market.

Store Levonis Bambini at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight. Do not freeze. Ensure the inhaler is kept upright and the mouthpiece is clean before each use.

Levonis Bambini is administered by inhalation using a metered‑dose inhaler or a similar device. Patients should shake the inhaler, exhale fully, place the mouthpiece in the mouth, and inhale slowly while actuating the device. Using a spacer can improve drug delivery and reduce oral side effects.

Serious risks include adrenal suppression, especially with high‑dose or prolonged use, growth retardation in children, severe allergic reactions such as anaphylaxis, and rare occurrences of pneumonia or cataracts. Patients should be monitored regularly for these potential complications.

Levonis Bambini should be avoided in individuals with known hypersensitivity to flunisolide or any component of the inhaler. It is also contraindicated in patients with active, untreated infections such as tuberculosis, and caution is advised in those with severe immunosuppression.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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