Product image of Levonor (Norepinephrine) supplied by GNH India

Levonor

Active Ingredient:
Norepinephrine
Origin:
EU

Levonor (Norepinephrine)

Norepinephrine, the active ingredient in Levonor, is a sympathomimetic presented as an injectable solution for intravenous use. It acts as a potent vasopressor to raise blood pressure in patients with severe hypotension, including those in septic or cardiogenic shock. It is indicated for rapid restoration of vascular tone in critical care settings and is administered under continuous hemodynamic monitoring.

GNH India supplies Levonor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to stringent quality standards and provides reliable logistics for global healthcare institutions.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Norepinephrine is used as a vasopressor to support circulatory function in acute hypotensive states.
  • Hypotension: raises systemic blood pressure to maintain organ perfusion.
  • Septic shock: restores vascular tone and improves hemodynamics in severe infection‑related hypotension.
  • Cardiogenic shock: supports cardiac output by increasing afterload and systemic pressure.

How It Works

  • Norepinephrine acts as a direct agonist at α1‑adrenergic receptors on vascular smooth muscle, causing potent vasoconstriction and increased systemic vascular resistance. It also stimulates β1‑adrenergic receptors in the heart, producing modest positive inotropic and chronotropic effects. The combined α‑mediated vasoconstriction and β‑mediated cardiac stimulation raise arterial pressure and improve tissue perfusion in shock states.

Side Effects

Norepinephrine may be associated with a range of adverse reactions, varying from frequent to rare but serious.

Common Side Effects

  • Headache: transient cranial pain during infusion.
  • Tachycardia: increased heart rate due to β1 stimulation.
  • Nausea: mild gastrointestinal discomfort.
  • Peripheral ischemia: reduced blood flow to extremities causing coldness or discoloration.

Serious or Rare Side Effects

  • Myocardial ischemia: chest pain or infarction from excessive coronary vasoconstriction.
  • Severe hypertension: abrupt rise in blood pressure that may cause vascular injury.
  • Tissue necrosis: extravasation at the infusion site leading to skin and muscle damage.

Precautions & Warnings

When using norepinephrine, careful monitoring and specific precautions are required to minimize risks.

  • Monitor blood pressure: adjust infusion to maintain target MAP.
  • Assess cardiac rhythm: watch for arrhythmias and ischemic changes.
  • Use caution in coronary artery disease: risk of myocardial ischemia.
  • Avoid extravasation: infiltrated drug can cause local tissue injury.
  • Limit use in severe hypertension: may exacerbate pressure elevation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Norepinephrine can interact with several medicines, influencing its efficacy or safety profile.

Major Interactions (Avoid)

  • MAO inhibitors: may potentiate hypertensive response.
  • Tricyclic antidepressants: increase catecholamine effects, raising blood pressure.
  • Ergot alkaloids: additive vasoconstriction can cause severe ischemia.

Moderate Interactions (Monitor Closely)

  • Vasodilators (e.g., nitroglycerin): may blunt pressor effect, requiring dose adjustments.
  • Beta‑blockers: can attenuate heart rate response while not affecting vasoconstriction.
  • ACE inhibitors or ARBs: may enhance hypotensive episodes if norepinephrine is tapered.

Frequently Asked Questions

Levonor contains norepinephrine, a vasopressor indicated for the rapid correction of severe hypotension, including hypotensive episodes associated with septic shock and cardiogenic shock. It helps restore adequate blood pressure and organ perfusion in critically ill patients under intensive monitoring.

Norepinephrine works by directly stimulating α1‑adrenergic receptors on blood vessels, causing strong vasoconstriction and raising systemic vascular resistance. It also activates β1‑adrenergic receptors in the heart, providing modest increases in heart contractility and rate, together elevating arterial pressure.

The dose of Levonor is individualized. A qualified prescriber determines the infusion rate based on the patient’s blood pressure, cardiac output, and response to therapy, titrating the drug to achieve the desired hemodynamic target.

Safety data for norepinephrine in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To order Levonor, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Levonor (norepinephrine) is generally preferred for septic shock because of its potent α‑mediated vasoconstriction with modest β‑activity, offering better blood pressure control than dopamine and fewer tachyarrhythmias than epinephrine. Choice of vasopressor depends on the clinical scenario and physician judgment.

Levonor should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use and discard any solution that appears discolored or contains particles.

Levonor is given as an intravenous infusion, typically through a central or large peripheral line. The infusion is started at a low rate and titrated continuously while monitoring blood pressure and heart rate to achieve the target hemodynamic response.

Serious risks include myocardial ischemia, severe hypertension that can cause vascular injury, and tissue necrosis if the drug extravasates from the vein. Continuous cardiac monitoring and careful site inspection are essential to detect these complications early.

Levonor is contraindicated in patients with known hypersensitivity to norepinephrine, uncontrolled severe hypertension, and those with significant peripheral vascular disease where further vasoconstriction could worsen tissue perfusion. Clinical judgment is required for each individual case.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Norepinephrine

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT