Product image of Levonorgestrel Apofri (Levonorgestrel) supplied by GNH India

Levonorgestrel Apofri

Active Ingredient:
Levonorgestrel
Origin:
EU

Levonorgestrel Apofri (Levonorgestrel)

Levonorgestrel, the active ingredient in Levonorgestrel Apofri, is a progestogen presented as an oral tablet for systemic use. It is employed to prevent pregnancy and can be used as emergency contraception after unprotected intercourse. It is indicated for routine contraception and as a single‑dose regimen for post‑coital use, providing a reliable, hormone‑based method to reduce the risk of implantation.

GNH India supplies Levonorgestrel Apofri as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance.

Manufacturer / TM Owner

Evolan Pharma Ab

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Indications & Clinical Uses

  • Levonorgestrel Apofri acts within the hormonal contraceptive pathway to prevent pregnancy.
  • Prevention of pregnancy: provides reliable contraceptive protection when taken as prescribed.
  • Emergency contraception: can be used after unprotected sexual intercourse to reduce the chance of pregnancy.
  • Menstrual cycle regulation: may be prescribed to manage certain menstrual disorders such as irregular bleeding.

How It Works

  • Levonorgestrel binds to progesterone receptors in the hypothalamus and pituitary, suppressing the luteinizing hormone surge needed for ovulation. It also thickens cervical mucus, hindering sperm penetration, and induces changes in the endometrial lining that make implantation of a fertilized egg unlikely.

Side Effects

Levonorgestrel Apofri may cause a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Nausea
  • Headache
  • Breast tenderness
  • Irregular vaginal bleeding
  • Fatigue
  • Mood changes

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Blood clots such as deep vein thrombosis
  • Liver dysfunction or hepatitis
  • Persistent abdominal pain
  • Unusual or prolonged vaginal bleeding

Precautions & Warnings

  • Before prescribing Levonorgestrel Apofri, clinicians should consider several precautionary measures to ensure safe use.
  • Medical history review: assess for thromboembolic disorders, liver disease, or hormone‑sensitive cancers.
  • Concurrent medication check: evaluate interactions with enzyme inducers or anticoagulants.
  • Pregnancy status: avoid use if the patient is already pregnant.
  • Breastfeeding: discuss potential risks with a healthcare provider.
  • Store at ambient temperature: keep below 25°C, in the original pack, and protect from moisture.

Avoid Interactions

Levonorgestrel Apofri can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Antiepileptic enzyme inducers (e.g., carbamazepine, phenytoin): may reduce contraceptive effectiveness.
  • Rifampin: can lower hormone levels and decrease efficacy.
  • Protease inhibitor antiretrovirals (e.g., ritonavir): may increase hormone concentrations, raising side‑effect risk.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles (e.g., ketoconazole): may raise levonorgestrel plasma levels.
  • St. John’s Wort: may diminish contraceptive effectiveness.
  • Anticoagulants (e.g., warfarin): may alter bleeding risk, requiring monitoring.

Frequently Asked Questions

Levonorgestrel Apofri is used as a hormonal contraceptive to prevent pregnancy during regular use and can also be taken as a single dose after unprotected sexual intercourse for emergency contraception. It works by inhibiting ovulation and altering the uterine lining to reduce the chance of implantation.

Levonorgestrel binds to progesterone receptors, suppressing the luteinizing hormone surge that triggers ovulation. It also thickens cervical mucus, making it harder for sperm to reach the egg, and modifies the endometrial lining, creating an environment that is unfavorable for implantation of a fertilized egg.

The specific dosing regimen for Levonorgestrel Apofri is determined by a qualified prescriber based on the intended use—whether for routine contraception or as emergency contraception. Healthcare professionals follow established clinical guidelines to select the appropriate dose and timing for each patient.

Levonorgestrel Apofri is not intended for use during an existing pregnancy and should be avoided if pregnancy is confirmed. While limited data exist for breastfeeding, the drug does pass into breast milk in small amounts; therefore, a healthcare provider should evaluate the risk‑benefit ratio before use in nursing mothers.

To order Levonorgestrel Apofri, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levonorgestrel Apofri is a progestogen‑based oral option that is effective when taken within 72 hours after unprotected intercourse. Compared with copper‑IUD insertion, it is less invasive but has a shorter window of maximal efficacy. Compared with ulipristal acetate, levonorgestrel is generally less expensive but may be slightly less effective after 48 hours.

Levonorgestrel Apofri tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original packaging to protect from moisture and light, and keep out of reach of children. Do not store in bathrooms or other humid environments.

Levonorgestrel Apofri is administered orally. For routine contraception, it is taken as directed by a prescriber, typically once daily or as a weekly regimen depending on the product formulation. For emergency use, a single tablet is taken as soon as possible after unprotected intercourse, following the prescriber’s instructions.

Serious risks, though rare, include severe allergic reactions (anaphylaxis), blood clot formation such as deep‑vein thrombosis, and liver dysfunction. Any signs of unusual bleeding, severe abdominal pain, or allergic symptoms should prompt immediate medical evaluation.

Women who are currently pregnant, have a known hypersensitivity to levonorgestrel or any tablet excipients, or have a history of thromboembolic disorders, severe liver disease, or hormone‑sensitive cancers should avoid using Levonorgestrel Apofri unless advised otherwise by a qualified healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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