Product image of Levonorgestrel/Etinilestradiol Diario Pensa (Ethinylestradiol, Levonorgestrel | Lactose Anhydrous) supplied by GNH India

Levonorgestrel/Etinilestradiol Diario Pensa

Active Ingredient:
Ethinylestradiol, Levonorgestrel | Lactose Anhydrous
Origin:
EU

Levonorgestrel/Etinilestradiol Diario Pensa (Ethinylestradiol, Levonorgestrel | Lactose Anhydrous)

Levonorgestrel/Ethinylestradiol, the active ingredient in Levonorgestrel/Etinilestradiol Diario Pensa, is a combined estrogen‑progestogen oral contraceptive presented as a tablet for oral use. It is used to prevent pregnancy in women of reproductive age by inhibiting ovulation, thickening cervical mucus, and altering the endometrium to reduce the chance of implantation.

GNH India supplies Levonorgestrel/Etinilestradiol Diario Pensa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU regulatory standards and is distributed under strict quality‑assurance protocols to ensure consistent potency and safety.

Manufacturer / TM Owner

Towa Pharmaceutical S.A.

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Indications & Clinical Uses

Levonorgestrel/Ethinylestradiol is a combined estrogen‑progestogen oral contraceptive used in hormonal contraception.

  • Prevention of pregnancy: provides reliable contraceptive protection.
  • Menstrual cycle regulation: helps establish regular menstrual bleeding patterns.
  • Acne management: may improve acne associated with hormonal fluctuations.

How It Works

  • Levonorgestrel/Ethinylestradiol combines an estrogen (ethinylestradiol) with a progestogen (levonorgestrel). Ethinylestradiol binds to estrogen receptors, providing negative feedback to the hypothalamic‑pituitary axis, while levonorgestrel activates progesterone receptors, suppressing the mid‑cycle luteinising hormone surge. The combined effect prevents follicular development and ovulation, thickens cervical mucus, and induces endometrial changes that reduce implantation potential. It also reduces secretion of follicle‑stimulating hormone, further stabilizing the ovarian environment.

Side Effects

Levonorgestrel/Ethinylestradiol may be associated with a range of adverse reactions, which are generally categorized by frequency.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like pain.
  • Breast tenderness: swelling or discomfort.
  • Irregular bleeding: spotting or breakthrough bleeding.

Serious or Rare Side Effects

  • Venous thromboembolism: deep vein thrombosis or pulmonary embolism.
  • Hypertension: significant increase in blood pressure.
  • Hepatic dysfunction: jaundice or abnormal liver enzymes.

Precautions & Warnings

Before prescribing Levonorgestrel/Ethinylestradiol, clinicians should consider several precautionary measures to ensure safe use.

  • Contraindications: avoid in women with a history of thromboembolic disorders, estrogen‑dependent tumors, or active liver disease.
  • Smoking: do not prescribe to smokers over 35 years of age due to increased cardiovascular risk.
  • Medication review: assess concurrent use of enzyme‑inducing drugs that may reduce contraceptive efficacy.
  • Pregnancy testing: confirm non‑pregnant status before initiating therapy.
  • Follow‑up: schedule periodic evaluation of blood pressure and menstrual patterns.
  • Store at ambient temperature: keep tablets below 25 °C in the original packaging, protected from moisture and light.

Avoid Interactions

Levonorgestrel/Ethinylestradiol can interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Antiepileptics: carbamazepine, phenytoin, phenobarbital may markedly reduce hormone levels, risking contraceptive failure.
  • Rifampicin: induces hepatic enzymes, decreasing contraceptive efficacy.
  • St. John’s wort: herbal inducer that can lower plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Antifungals: ketoconazole, itraconazole may increase hormone levels, potentially enhancing side effects.
  • Antiretrovirals: protease inhibitors can affect hormone metabolism; monitor for efficacy.
  • Diuretics: may increase risk of hypertension; observe blood pressure.

Frequently Asked Questions

Levonorgestrel/Ethinylestradiol is a combined oral contraceptive indicated primarily for the prevention of pregnancy in women of reproductive age. It is also prescribed to help regulate menstrual cycles and may improve acne that is related to hormonal fluctuations.

The product combines ethinylestradiol, an estrogen, with levonorgestrel, a progestogen. Ethinylestradiol provides negative feedback to the hypothalamic‑pituitary axis, while levonorgestrel suppresses the luteinising hormone surge. Together they inhibit ovulation, thicken cervical mucus, and induce endometrial changes that reduce the likelihood of implantation.

The specific dosing regimen is determined by the prescribing healthcare professional. Typically, the medication is taken as one tablet daily at the same time each day, but the exact strength, duration and any cycle‑specific instructions are set by the prescriber based on individual patient needs.

Levonorgestrel/Ethinylestradiol is not intended for use during an established pregnancy and should be discontinued if pregnancy occurs. While limited data exist for breastfeeding, most guidelines advise caution; the benefits and risks should be evaluated by a healthcare provider before use in lactating women.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then provides pricing, availability, shipping details and any necessary import documentation.

Levonorgestrel/Ethinylestradiol contains a widely used progestogen (levonorgestrel) and a standard estrogen dose (ethinylestradiol), offering a balance of efficacy and tolerability comparable to other second‑generation combined pills. Compared with newer formulations that use different progestogens, it may have a slightly higher risk of acne but a well‑characterized safety profile.

Store the tablets at ambient temperature, preferably below 25 °C, in the original blister pack or bottle. Protect them from excess moisture, direct sunlight and heat. Do not store in the bathroom or near a kitchen sink. Keep out of reach of children.

The medication is taken orally as a tablet. Patients should swallow the tablet whole with water, preferably at the same time each day, and should not skip doses. If a dose is missed, follow the specific guidance provided by the prescriber or the product leaflet.

The most serious adverse events include venous thromboembolism (such as deep‑vein thrombosis or pulmonary embolism), arterial thrombosis leading to stroke or myocardial infarction, severe hypertension, and hepatic disorders. Prompt medical attention is required if symptoms such as sudden leg pain, chest pain, severe headache, or jaundice develop.

Women with a history of thromboembolic disease, estrogen‑dependent tumors (e.g., breast cancer), uncontrolled hypertension, active liver disease, or known hypersensitivity to any component should avoid this product. It is also contraindicated in smokers over 35 years of age and in women who are currently pregnant.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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