Product image of Levonorgestrel Sameko (Levonorgestrel) supplied by GNH India

Levonorgestrel Sameko

Active Ingredient:
Levonorgestrel
Origin:
EU

Levonorgestrel Sameko (Levonorgestrel)

Levonorgestrel, the active ingredient in Levonorgestrel Sameko, is a synthetic progestin presented as an oral tablet for oral administration. It works to prevent pregnancy by inhibiting ovulation and altering cervical mucus, and is indicated for emergency contraception and ongoing contraceptive use in women of reproductive age.

GNH India supplies Levonorgestrel Sameko as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑compliant documentation for global distribution. Customers benefit from reliable supply chains and responsive technical support.

Manufacturer / TM Owner

Sameko Farma B.V.

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Indications & Clinical Uses

Levonorgestrel Sameko is a progestin used in contraceptive pathways to prevent unintended pregnancy.

  • Emergency contraception: prevents pregnancy after unprotected intercourse when taken within the recommended time frame.
  • Regular contraception: incorporated into hormonal regimens to inhibit ovulation and maintain contraceptive efficacy.
  • Post‑coital contraception: provides a high dose that interferes with fertilization and implantation.

How It Works

  • Levonorgestrel binds to progesterone receptors in the hypothalamus and pituitary, suppressing the luteinizing hormone surge and thereby preventing ovulation. It also thickens cervical mucus, reducing sperm penetration, and induces endometrial changes that are unfavorable for implantation, collectively contributing to contraceptive efficacy.

Side Effects

Levonorgestrel may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Headache: transient cranial discomfort.
  • Abdominal pain: cramping or lower abdominal discomfort.
  • Fatigue: feeling unusually tired.
  • Menstrual changes: spotting, earlier or delayed periods.
  • Dizziness: light‑headed sensation.

Serious or Rare Side Effects

  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Liver dysfunction: jaundice or abnormal liver enzymes.
  • Ectopic pregnancy: implantation outside the uterus.
  • Persistent pelvic pain: may indicate underlying pathology.
  • Vision changes: rare ocular disturbances.

Precautions & Warnings

Before using Levonorgestrel Sameko, consider the following safety measures.

  • Medical history review: assess for clotting disorders, liver disease, or hormone‑sensitive cancers.
  • Pregnancy status: avoid use if already pregnant; confirm negative pregnancy test when appropriate.
  • Breastfeeding: discuss risks with a healthcare professional before use.
  • Concomitant medications: evaluate potential interactions with enzyme‑inducing drugs.
  • Thrombosis monitoring: watch for leg swelling, chest pain, or shortness of breath.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel can interact with other medicines, affecting its effectiveness.

Major Interactions (Avoid)

  • Rifampin: strong enzyme inducer that reduces contraceptive efficacy.
  • Carbamazepine: decreases plasma levels of levonorgestrel.
  • Phenytoin: may lower hormonal concentrations.
  • St. John's wort: herbal inducer that can compromise effectiveness.
  • Griseofulvin: reduces contraceptive reliability.

Moderate Interactions (Monitor Closely)

  • Ketoconazole: antifungal that may increase hormone levels.
  • HIV protease inhibitors: can alter metabolism of levonorgestrel.
  • Hormonal therapy: combined use may require dosage adjustment.
  • Antiretroviral agents (e.g., efavirenz): may affect drug levels.
  • Certain antibiotics (e.g., metronidazole): monitor for reduced efficacy.

Frequently Asked Questions

Levonorgestrel Sameko is used as a hormonal contraceptive to prevent pregnancy. It is indicated for emergency (post‑coital) contraception when taken shortly after unprotected intercourse, and it can also be part of a regular contraceptive regimen to inhibit ovulation and reduce the chance of fertilisation.

Levonorgestrel acts by binding to progesterone receptors, suppressing the luteinising hormone surge that triggers ovulation. It also thickens cervical mucus, making it harder for sperm to travel, and alters the endometrium so that implantation of a fertilised egg is unlikely.

The specific dose and regimen of Levonorgestrel Sameko are determined by the prescribing healthcare professional based on the indication, timing of administration, and individual patient factors. Patients should follow the prescriber’s instructions and not alter the dose on their own.

Levonorgestrel is not intended for use during an established pregnancy and should be avoided if a woman is already pregnant. For breastfeeding mothers, the drug does pass into breast milk in small amounts; healthcare providers usually assess the risk‑benefit ratio before recommending use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levonorgestrel is a progestin‑only emergency contraceptive that is effective when taken within 72 hours of unprotected intercourse. Compared with copper‑IUD insertion, which can be effective up to five days, levonorgestrel is less invasive but requires timely administration. Other hormonal options, such as ulipristal acetate, may have a slightly longer window of efficacy.

Levonorgestrel Sameko should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack, protect them from moisture, heat and direct sunlight, and ensure the container is tightly closed when not in use.

The product is taken orally, usually as a single tablet or as directed by a healthcare professional. For emergency contraception, the tablet should be swallowed with water as soon as possible after unprotected sex, ideally within the recommended time frame.

Serious but rare risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, severe allergic reactions (anaphylaxis), and liver dysfunction. Any signs of unusual pain, swelling, shortness of breath, rash, or jaundice should prompt immediate medical attention.

Women who are currently pregnant, have a known hypersensitivity to levonorgestrel or any tablet excipients, have active or history of thromboembolic disorders, or have severe liver disease should avoid using Levonorgestrel Sameko. A healthcare professional should evaluate suitability on an individual basis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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