Product image of Levophed (Noradrenaline Tartrate) supplied by GNH India

Levophed

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Levophed (Noradrenaline Tartrate)

norepinephrine, the active ingredient in Levophed, is a sympathomimetic (vasopressor) presented as an injection for intravenous use. It is employed to raise blood pressure in patients with septic shock, cardiogenic shock, acute hypotension, and post‑cardiac surgery hypotension.
GNH India supplies Levophed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Hospira Benelux

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Indications & Clinical Uses

Levophed acts on the sympathetic nervous system to restore vascular tone and cardiac output in critical‑care settings.

  • Septic shock: improves blood pressure and organ perfusion.
  • Cardiogenic shock: supports cardiac output when the heart fails to pump adequately.
  • Acute hypotension: rapidly raises systemic vascular resistance to prevent organ ischemia.
  • Post‑cardiac surgery hypotension: stabilises haemodynamics after operative procedures.

How It Works

  • Norepinephrine tartrate is a direct agonist of alpha‑1 and beta‑1 adrenergic receptors. Stimulation of alpha‑1 receptors causes potent vasoconstriction, increasing systemic vascular resistance, while beta‑1 activation enhances myocardial contractility and heart rate, together raising arterial pressure and cardiac output in acute shock states.

Side Effects

Levophed may cause a range of adverse reactions that require monitoring.

Common Side Effects

  • Headache: mild to moderate discomfort.
  • Tachycardia: increased heart rate due to beta‑1 stimulation.
  • Arrhythmia: irregular heart rhythm, often transient.
  • Peripheral ischemia: reduced blood flow to extremities.
  • Nausea: occasional gastrointestinal upset.
  • Anxiety: heightened nervousness or restlessness.

Serious or Rare Side Effects

  • Myocardial ischemia: reduced heart muscle blood flow.
  • Severe hypertension: dangerously high blood pressure.
  • Tissue necrosis at infusion site: local tissue death if extravasation occurs.
  • Life‑threatening arrhythmias: ventricular tachycardia or fibrillation.
  • Pulmonary edema: fluid accumulation in lungs.
  • Severe bradycardia: markedly slow heart rate.

Precautions & Warnings

Levophed requires careful clinical oversight because of its potent cardiovascular effects.

  • Blood pressure monitoring: continuous arterial line measurement is essential.
  • Cardiac monitoring: ECG should be observed for arrhythmias.
  • Dose titration: adjust infusion rate to achieve target pressure without overshoot.
  • Extravasation risk: avoid infiltration; stop infusion immediately if signs appear.
  • Coronary artery disease: use cautiously, as increased demand may provoke ischemia.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levophed can interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Beta‑blockers: may blunt desired increase in cardiac output.
  • Tricyclic antidepressants: heightened risk of arrhythmias.

Moderate Interactions (Monitor Closely)

  • Vasodilators (e.g., nitroglycerin): may require higher norepinephrine doses.
  • ACE inhibitors: additive blood pressure effects.
  • Diuretics: potential volume depletion influencing response.
  • Calcium channel blockers: may affect vascular tone.
  • Other catecholamines: cumulative sympathomimetic activity.

Frequently Asked Questions

Levophed is a brand name for norepinephrine tartrate, an injectable vasopressor used in intensive‑care settings to treat severe hypotension, including septic shock, cardiogenic shock, and hypotension following cardiac surgery. It works by constricting blood vessels and increasing heart contractility to raise blood pressure.

Norepinephrine acts as a direct agonist at alpha‑1 and beta‑1 adrenergic receptors. Alpha‑1 activation causes strong vasoconstriction, raising systemic vascular resistance, while beta‑1 activation enhances myocardial contractility and heart rate, together improving cardiac output and arterial pressure.

The dose of Levophed is individualized by the treating physician based on the patient’s haemodynamic status. It is administered as a continuous intravenous infusion, and the rate is titrated to achieve the desired blood pressure target while monitoring for adverse effects.

The safety of Levophed (norepinephrine) in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by the prescribing clinician.

To order Levophed, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Levophed (norepinephrine) is often preferred as a first‑line vasopressor because it provides both potent vasoconstriction and modest inotropic support. Alternatives such as dopamine or phenylephrine may have different receptor profiles, with dopamine offering more dose‑dependent effects and phenylephrine being a pure alpha‑agonist without beta activity.

Levophed should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. The product should be kept in its original packaging until use, and any unused portion should be discarded according to local regulations after the recommended storage period.

Levophed is given by intravenous infusion, typically through a central venous catheter. The infusion is started at a low rate and titrated upward under continuous blood pressure and cardiac monitoring to achieve the desired haemodynamic response.

Serious risks include severe hypertension, myocardial ischemia, life‑threatening arrhythmias, tissue necrosis at the infusion site due to extravasation, and pulmonary edema. Prompt recognition and management of these events are essential, and the drug should be administered only in settings equipped for intensive monitoring.

Levophed is contraindicated in patients with known hypersensitivity to norepinephrine or any component of the formulation. Caution is advised in individuals with severe peripheral vascular disease, uncontrolled arrhythmias, or those receiving MAO inhibitors, as the drug may exacerbate these conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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