Product image of Levoreact Oftalmico (Levocabastine Hydrochloride) supplied by GNH India

Levoreact Oftalmico

Active Ingredient:
Levocabastine Hydrochloride
Origin:
EU

Levoreact Oftalmico (Levocabastine Hydrochloride)

Levocabastine Hydrochloride, the active ingredient in Levoreact Oftalmico, is a H1 receptor antagonist presented as an ophthalmic solution for ocular use. It alleviates itching, redness and swelling caused by allergic eye conditions in patients with allergic conjunctivitis and related disorders.

GNH India supplies Levoreact Oftalmico as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Johnson & Johnson S.P.A.

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Indications & Clinical Uses

Levocabastine Hydrochloride is used to manage ocular allergic reactions by blocking histamine H1 receptors.

  • Allergic conjunctivitis: reduces itching, redness and swelling.
  • Seasonal allergic eye disease: provides rapid symptom relief.
  • Vernal keratoconjunctivitis: eases ocular discomfort and inflammation.

How It Works

  • Levocabastine Hydrochloride selectively binds to histamine H1 receptors on conjunctival mast cells and sensory nerves, preventing histamine from triggering the cascade that leads to itching, vasodilation and inflammatory mediator release. By blocking this pathway, the drug reduces ocular irritation and allergic inflammation without significant systemic absorption.

Side Effects

Common Side Effects

  • Transient burning or stinging sensation on instillation.
  • Mild ocular redness or hyperemia.
  • Temporary blurred vision.
  • Increased tearing.
  • Mild headache.
  • Slight eye discomfort.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis) with swelling and difficulty breathing.
  • Corneal ulceration or epithelial defect.
  • Persistent ocular pain or photophobia.
  • Vision loss or significant visual disturbance.
  • Severe intraocular inflammation.

Precautions & Warnings

Levocabastine ophthalmic solution should be used with caution in the following situations:

  • Known hypersensitivity to levocabastine or any excipient: discontinue use.
  • Pre‑existing ocular infection or severe inflammation: avoid unless directed by a specialist.
  • Patients with glaucoma or ocular hypertension: monitor intra‑ocular pressure.
  • Pregnancy and breastfeeding: safety not established; consult a physician.
  • Store at room temperature (below 25°C): keep in original container, protect from moisture and light.

Avoid Interactions

Levocabastine ophthalmic solution may interact with other ocular medications.

Major Interactions (Avoid)

  • Concurrent use of other topical antihistamines: may increase ocular irritation.
  • Combination with vasoconstrictive decongestants: risk of excessive local vasoconstriction.

Moderate Interactions (Monitor Closely)

  • Systemic antihistamines: possible reduction of levocabastine efficacy.
  • Contact lens wear: may cause increased discomfort or lens deposits.
  • Co‑administration with ophthalmic corticosteroids: monitor for additive anti‑inflammatory effects.

Frequently Asked Questions

Levoreact Oftalmico is an ophthalmic solution containing levocabastine hydrochloride. It is used to relieve symptoms of ocular allergies such as itching, redness, and swelling caused by conditions like allergic conjunctivitis and seasonal allergic eye disease.

Levocabastine acts as a selective H1 receptor antagonist. By binding to histamine H1 receptors on conjunctival cells and sensory nerves, it blocks histamine‑induced itching and inflammatory responses, providing rapid relief of allergic eye symptoms.

The dosing regimen for Levoreact Oftalmico is determined by the prescribing clinician based on the severity of the allergic condition and patient response. The prescriber will specify the number of drops and frequency of administration.

Safety data for levocabastine hydrochloride in pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits against any possible risks before prescribing it to pregnant or nursing individuals.

To request Levoreact Oftalmico, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levoreact contains levocabastine, a selective H1 antagonist known for rapid onset of action and minimal systemic absorption. Compared with non‑selective antihistamines, it often offers quicker symptom relief and a lower incidence of systemic side effects, though individual response may vary.

Levoreact should be stored at room temperature, preferably below 25 °C. Keep the bottle in its original packaging, protect it from moisture and direct sunlight, and ensure the cap is tightly closed to maintain sterility.

Levoreact is applied topically to the eye. The patient should wash their hands, tilt the head back, pull down the lower eyelid, and instill the prescribed number of drops into the conjunctival sac. Avoid touching the tip of the bottle to the eye or any surface.

Serious risks, although rare, include severe allergic reactions such as anaphylaxis, corneal ulceration, persistent ocular pain, and significant visual disturbances. Patients should seek immediate medical attention if they experience any of these symptoms.

Individuals with known hypersensitivity to levocabastine hydrochloride or any excipients in the formulation should avoid using Levoreact. Additionally, patients with active ocular infections, severe inflammation, or uncontrolled glaucoma should consult a specialist before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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