Product image of Levorol (Levomepromazine) supplied by GNH India

Levorol

Active Ingredient:
Levomepromazine
Origin:
EU

Levorol (Levomepromazine)

Levomepromazine, the active ingredient in Levorol, is a phenothiazine antipsychotic presented as an oral tablet for oral use. It treats schizophrenia, severe agitation, nausea and vomiting, and is used in palliative care for symptom control. It works by blocking dopamine D2 receptors as well as histamine, muscarinic and alpha‑adrenergic receptors.

GNH India supplies Levorol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Galvany Pharma Limited

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Indications & Clinical Uses

Levomepromazine is used in the management of psychotic disorders and related conditions.

  • Schizophrenia: reduces delusions, hallucinations and other psychotic symptoms.
  • Severe agitation: calms acute agitation and aggressive behaviour.
  • Nausea and vomiting: controls refractory nausea, especially in oncology or palliative settings.
  • Palliative care symptom control: alleviates anxiety, pain‑related insomnia and refractory nausea.

How It Works

  • Levomepromazine antagonises dopamine D2 receptors, which diminishes dopaminergic neurotransmission responsible for psychosis. It also blocks histamine H1, muscarinic and alpha‑adrenergic receptors, contributing to its sedative, anti‑emetic and antihypertensive effects. The combined receptor blockade underlies its utility in psychotic disorders, severe agitation, nausea, and palliative symptom management.

Side Effects

Levomepromazine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Drowsiness: sedation and fatigue.
  • Dry mouth: reduced salivation.
  • Constipation: slowed gastrointestinal motility.
  • Orthostatic hypotension: dizziness upon standing.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: muscle rigidity, tremor, or dystonia.
  • Neuroleptic malignant syndrome: fever, muscle rigidity, autonomic instability.
  • Tardive dyskinesia: involuntary movements after prolonged use.
  • Cardiac arrhythmias: QT prolongation or other rhythm disturbances.

Precautions & Warnings

When prescribing levomepromazine, clinicians should consider several safety measures.

  • Monitor blood pressure: watch for orthostatic hypotension especially at treatment start.
  • Assess cardiac risk: obtain ECG if the patient has known QT‑prolongation.
  • Evaluate hepatic function: dose adjustment may be needed in severe liver impairment.
  • Use caution in the elderly: increased sensitivity to sedative and anticholinergic effects.
  • Avoid abrupt discontinuation: taper gradually to reduce withdrawal or rebound agitation.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Levomepromazine interacts with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Other CNS depressants: may enhance sedation and respiratory depression.
  • Anticholinergic drugs: increase risk of severe anticholinergic toxicity.
  • QT‑prolonging agents: additive risk of cardiac arrhythmias.
  • MAO inhibitors: can cause unpredictable hypotension and sedation.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: may potentiate orthostatic hypotension.
  • Antidiabetic agents: possible alteration of glucose control.
  • CYP450 inhibitors/inducers: may affect levomepromazine plasma levels.

Frequently Asked Questions

Levorol contains levomepromazine, a phenothiazine antipsychotic indicated for schizophrenia, severe agitation, refractory nausea and vomiting, and for symptom control in palliative care settings such as anxiety, pain‑related insomnia and nausea.

Levomepromazine blocks dopamine D2 receptors, reducing psychotic signalling, and also antagonises histamine H1, muscarinic and alpha‑adrenergic receptors. This combined blockade provides antipsychotic, sedative, anti‑emetic and antihypertensive effects.

The appropriate dose of levomepromazine is individualized. A qualified prescriber determines the starting dose, titration schedule and maintenance dose based on the patient’s condition, age, renal and hepatic function, and response to therapy.

Safety data for levomepromazine in pregnancy and lactation are limited. It should only be used when the potential benefit outweighs the possible risk to the fetus or infant, and the decision must be made by the treating physician.

To request Levorol, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with atypical antipsychotics, levomepromazine has stronger antihistamine, anticholinergic and alpha‑adrenergic blockade, which can be advantageous for sedation and anti‑emetic needs but may increase the risk of sedation, hypotension and anticholinergic side effects. It is often chosen when these additional properties are clinically useful.

Levorol tablets should be stored at ambient temperature, preferably below 25 °C, in the original container to protect them from moisture and light. Keep out of reach of children and do not use if the packaging is damaged.

Levorol is taken orally as a tablet. It should be swallowed whole with a glass of water, with or without food, unless the prescriber advises otherwise. The exact timing and any food considerations are determined by the treating clinician.

Serious adverse reactions include neuroleptic malignant syndrome, tardive dyskinesia, severe extrapyramidal symptoms, and cardiac arrhythmias such as QT prolongation. Patients should be monitored closely for fever, muscle rigidity, sudden changes in movement or heart rhythm disturbances.

Levorol is contraindicated in individuals with known hypersensitivity to levomepromazine or any phenothiazine, in patients with severe central nervous system depression, and in those with uncontrolled cardiac arrhythmias or a history of neuroleptic malignant syndrome.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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