Product image of Levosert (Levonorgestrel) supplied by GNH India

Levosert

Active Ingredient:
Levonorgestrel
Origin:
EU

Levosert (Levonorgestrel)

Levonorgestrel, the active ingredient in Levosert, is a progestogen presented as a 52 mg intrauterine system (IUS) for intrauterine use. It delivers a steady low dose of levonorgestrel to provide long‑acting reversible contraception for women of reproductive age, through a single device placed by a qualified clinician.

GNH India supplies Levosert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable access to this intrauterine contraceptive system. Our distribution network ensures compliance with local regulatory requirements and timely delivery.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

  • Levosert, containing levonorgestrel, is used in the hormonal contraceptive pathway to prevent pregnancy.
  • Contraception: provides continuous birth control for up to five years.
  • Heavy menstrual bleeding: reduces menstrual blood loss and may improve dysmenorrhea.
  • Endometrial protection: maintains a thin endometrium, lowering the risk of endometrial hyperplasia.

How It Works

  • Levonorgestrel released from the intrauterine system binds to progesterone receptors in the endometrium, cervical mucus, and hypothalamic‑pituitary axis. This suppresses ovulation, thickens cervical mucus to impede sperm passage, and induces endometrial atrophy, collectively preventing implantation and providing long‑acting reversible contraception.

Side Effects

Levosert may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Irregular bleeding or spotting
  • Amenorrhea (absence of periods)
  • Cervical discharge
  • Pelvic or abdominal cramping
  • Headache

Serious or Rare Side Effects

  • Uterine perforation during insertion or removal
  • Expulsion of the intrauterine system
  • Pelvic inflammatory disease or infection
  • Ectopic pregnancy if contraception fails
  • Severe allergic reaction (anaphylaxis)

Precautions & Warnings

  • Before insertion, clinicians should evaluate patients for contraindications and counsel on expected changes.
  • Screening: confirm absence of active pelvic infection, uterine anomalies, or malignancy.
  • Pregnancy testing: ensure the patient is not pregnant at the time of insertion.
  • Follow‑up: schedule a post‑insertion visit to verify correct placement.
  • Bleeding patterns: advise that menstrual bleeding may become irregular, lighter, or cease.
  • Removal: device should be removed by a qualified provider after the intended duration or if complications arise.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel levels can be altered by other medicines, requiring attention to potential efficacy changes.

Major Interactions (Avoid)

  • Enzyme inducers such as rifampicin that markedly reduce levonorgestrel concentrations.
  • Antiepileptic drugs (e.g., carbamazepine, phenytoin) that may compromise contraceptive effectiveness.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles (e.g., ketoconazole) that can increase levonorgestrel exposure.
  • Certain antiretrovirals (e.g., efavirenz) that may lower hormone levels.
  • Herbal supplements like St. John’s wort that may affect hormonal metabolism.

Frequently Asked Questions

Levosert is a levonorgestrel‑releasing intrauterine system indicated for long‑acting reversible contraception. It provides continuous birth control for up to five years and can also be used to reduce heavy menstrual bleeding and improve menstrual regularity in women of reproductive age.

Levonorgestrel released from the IUS binds to progesterone receptors in the endometrium, cervical mucus, and the hypothalamic‑pituitary axis. This suppresses ovulation, thickens cervical mucus to block sperm, and creates an atrophic endometrium, together preventing implantation.

Levosert is supplied as a single 52 mg intrauterine system that releases approximately 20 µg of levonorgestrel per day. The exact dosing regimen, including insertion timing and duration of use, is determined by the prescribing clinician based on individual patient needs.

Levosert is contraindicated in women who are pregnant; it should be inserted only after confirming a negative pregnancy test. Limited data are available for breastfeeding, and clinicians should weigh potential risks and benefits before use in lactating women.

To order Levosert, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with oral progestin‑only pills, Levosert offers a once‑inserted, maintenance‑free option with higher typical‑use efficacy and no daily adherence. Unlike copper IUDs, it may reduce menstrual bleeding and cause fewer menstrual cramps, though copper devices have no hormonal side effects.

Levosert should be stored at ambient temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight, and physical damage until it is inserted by a qualified healthcare professional.

Levosert is inserted into the uterine cavity by a trained clinician using a sterile insertion kit. The procedure is performed in a clinical setting under aseptic conditions, and placement is confirmed by pelvic examination or ultrasound as needed.

Serious risks include uterine perforation during insertion or removal, infection such as pelvic inflammatory disease, expulsion of the device, and the rare possibility of ectopic pregnancy if contraceptive failure occurs. Prompt medical evaluation is required if any of these events are suspected.

Levosert is contraindicated in women with current pelvic infection, known or suspected uterine or cervical malignancy, unexplained vaginal bleeding, uterine anomalies that preclude proper placement, or a history of severe allergic reaction to levonorgestrel or device components.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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