Product image of Levosert (Levonorgestrel) supplied by GNH India

Levosert

Active Ingredient:
Levonorgestrel
Origin:
EU

Levosert (Levonorgestrel)

Levonorgestrel, the active ingredient in Levosert, is a progestogen presented as a 52 mg intrauterine system for intrauterine use. It provides long‑acting reversible contraception and prevents pregnancy.

GNH India supplies Levosert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

Levosert, a levonorgestrel‑based intrauterine system, is used for hormonal contraception.

  • Contraception: provides continuous pregnancy prevention for up to five years.
  • Management of heavy menstrual bleeding: may reduce the volume and duration of bleeding.
  • Non‑oral hormonal birth control: offers a progestogen‑only option for women who prefer an intrauterine method.

How It Works

  • Levosert releases levonorgestrel locally within the uterine cavity. The hormone binds to progesterone receptors, suppressing ovulation, thickening cervical mucus to impede sperm passage, and inducing endometrial changes that reduce the likelihood of implantation, thereby delivering effective, long‑acting contraception.

Side Effects

Levosert may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Irregular vaginal bleeding or spotting.
  • Menstrual cramps or pelvic discomfort after insertion.
  • Amenorrhea (absence of periods) after several months.
  • Vaginal discharge or odor.

Serious or Rare Side Effects

  • Uterine perforation during insertion.
  • Expulsion of the device.
  • Pelvic inflammatory disease or severe infection.
  • Allergic reaction to levonorgestrel or device components.

Precautions & Warnings

Before using Levosert, clinicians should assess patient suitability and counsel on potential risks.

  • Uterine assessment: confirm normal cavity size and shape.
  • Infection screening: ensure no active pelvic infection.
  • Contraindications: avoid in women with known hypersensitivity to levonorgestrel.
  • Insertion technique: performed by trained healthcare professional.
  • Follow‑up: monitor for signs of expulsion or infection.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levosert can interact with medications that affect hormone metabolism or uterine environment.

Major Interactions (Avoid)

  • Rifampicin or other strong enzyme inducers: may reduce levonorgestrel efficacy.
  • Antiepileptic drugs such as carbamazepine or phenytoin: can lower hormone levels.
  • St John's wort: may diminish contraceptive effect.

Moderate Interactions (Monitor Closely)

  • Certain antiretrovirals (e.g., efavirenz): may modestly decrease effectiveness.
  • Antifungal agents like ketoconazole: could increase hormone exposure.
  • Hormonal therapies (e.g., estrogen patches): assess combined hormonal impact.

Frequently Asked Questions

Levosert is an intrauterine system that delivers levonorgestrel directly to the uterus. It is used as a long‑acting reversible contraceptive to prevent pregnancy for up to five years, providing a non‑oral, hormone‑based birth control option.

Levonorgestrel released from Levosert binds to progesterone receptors in the uterine lining. This action suppresses ovulation, thickens cervical mucus to block sperm, and creates endometrial changes that make implantation unlikely, resulting in effective contraception.

Levosert is supplied as a pre‑loaded 52 mg intrauterine system. The exact dosing regimen, including insertion timing and follow‑up schedule, is determined by the prescribing clinician based on individual patient factors and regulatory guidelines.

Levosert is intended for use in women who are not pregnant. If pregnancy occurs, the device should be removed. Limited data are available for breastfeeding; clinicians should weigh benefits against potential risks and discuss options with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levosert delivers a higher total amount of levonorgestrel (52 mg) than many copper IUDs, offering a hormone‑based mechanism that can reduce menstrual bleeding. Unlike copper devices, it does not rely on a foreign metal surface, which may be preferable for women with metal sensitivities.

Levosert should be stored at room temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight, and physical damage until it is inserted by a qualified healthcare professional.

Levosert is inserted into the uterine cavity by a trained clinician using a specialized inserter. The procedure is performed in a clinical setting under aseptic conditions, and the device remains in place for up to five years, after which it can be removed or replaced.

Serious risks include uterine perforation during insertion, device expulsion, and pelvic inflammatory disease. Rarely, allergic reactions to levonorgestrel or device components may occur. Patients should seek immediate medical attention if they experience severe abdominal pain, fever, or abnormal bleeding.

Levosert is contraindicated in women with active pelvic infection, known hypersensitivity to levonorgestrel, uterine anomalies that prevent proper placement, or current pregnancy. Women with a history of breast cancer or thromboembolic disorders should discuss alternative contraceptive methods with their healthcare provider.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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