Product image of Levosert (Levonorgestrel) supplied by GNH India

Levosert

Active Ingredient:
Levonorgestrel
Origin:
EU

Levosert (Levonorgestrel)

Levonorgestrel, the active ingredient in Levosert, is a progestogen presented as a 52 mg intrauterine system for intrauterine use. It provides hormonal contraception and can be used to manage heavy menstrual bleeding in women of reproductive age.

GNH India supplies Levosert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gedeon Richter Plc.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Levosert, a levonorgestrel‑releasing intrauterine system, is indicated for hormonal contraceptive and menstrual‑related indications.
  • Contraception: provides up to five years of highly effective birth control for women of reproductive age.
  • Heavy menstrual bleeding: reduces menstrual blood loss and improves anemia associated with excessive bleeding.

How It Works

  • Levonorgestrel released from the intrauterine system binds to progesterone receptors in the endometrium, cervical mucus and ovary. The hormone suppresses ovulation, thickens cervical mucus to impede sperm penetration, and induces endometrial atrophy, creating conditions that prevent implantation and markedly reduce menstrual bleeding.

Side Effects

Levosert may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Irregular bleeding or spotting
  • Amenorrhea (absence of periods)
  • Cramping or pelvic pain after insertion
  • Headache
  • Breast tenderness
  • Mood changes

Serious or Rare Side Effects

  • Uterine perforation during insertion
  • Expulsion of the device
  • Pelvic inflammatory disease
  • Ectopic pregnancy if contraception fails
  • Ovarian cyst formation
  • Severe allergic reaction to device components

Precautions & Warnings

Before insertion, clinicians should assess patient suitability and counsel on potential risks.

  • Confirm non‑pregnancy: verify negative pregnancy test before placement.
  • Screen for active pelvic infection: avoid insertion in presence of PID or severe cervicitis.
  • Review uterine anatomy: ensure appropriate cavity size and position.
  • Counsel on bleeding changes: inform patients about possible spotting or amenorrhea.
  • Assess contraindications: avoid in women with known levonorgestrel hypersensitivity or liver disease.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levosert may interact with systemic agents that alter steroid metabolism.

Major Interactions (Avoid)

  • Rifampin and other strong enzyme inducers: may reduce levonorgestrel efficacy.
  • Certain antiepileptic drugs (e.g., carbamazepine, phenytoin): can lower hormone levels.
  • Antifungal azoles (e.g., ketoconazole): may increase levonorgestrel concentrations.

Moderate Interactions (Monitor Closely)

  • St. John's wort: potential reduction in hormone effect, monitor for breakthrough bleeding.
  • Protease inhibitors used in HIV therapy: may affect levonorgestrel metabolism, consider alternative contraception.

Frequently Asked Questions

Levosert is a levonorgestrel‑releasing intrauterine system indicated for hormonal contraception up to five years and for the medical management of heavy menstrual bleeding in women of reproductive age. It provides a localized, steady release of progestogen to prevent pregnancy and reduce menstrual blood loss.

Levonorgestrel released from the intrauterine system acts on the endometrium, cervical mucus and ovary. It suppresses ovulation, thickens cervical mucus to impede sperm passage, and induces endometrial atrophy, creating an environment that prevents implantation and reduces menstrual bleeding.

The dosing regimen of Levosert is determined by the prescribing clinician. The device contains 52 mg of levonorgestrel and releases approximately 20 µg per day for up to five years; the prescriber decides insertion timing and follow‑up schedule based on individual patient needs.

Levosert is classified as pregnancy category X; it must not be used in women who are pregnant or who intend to become pregnant. Breastfeeding is not a contraindication after insertion, but women should discuss any concerns with their healthcare provider, as hormonal exposure may affect milk production.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with combined oral contraceptives, Levosert offers a “set‑and‑forget” approach with continuous low‑dose levonorgestrel release, eliminating daily adherence. Unlike copper IUDs, it reduces menstrual bleeding and may improve anemia, but it does not protect against sexually transmitted infections.

Store Levosert at room temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture and direct sunlight. Do not attempt to open or manipulate the intrauterine system before insertion by a qualified healthcare professional.

Levosert is inserted into the uterine cavity by a trained clinician using a specialized inserter. The procedure is performed in a clinical setting under aseptic conditions, typically during the early follicular phase of the menstrual cycle. Once placed, the device remains effective for up to five years without further dosing.

Serious but uncommon risks include uterine perforation during insertion, expulsion of the device, pelvic inflammatory disease, and ectopic pregnancy if contraception fails. Users should seek immediate medical attention for severe abdominal pain, abnormal bleeding, or signs of infection.

Levosert is contraindicated in women who are pregnant, have current or suspected pelvic infection, unexplained vaginal bleeding, known or suspected uterine malignancy, or a history of severe allergic reaction to levonorgestrel. It should also be avoided in individuals with active liver disease or known hypersensitivity to the device components.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.