Product image of Levosert (Levonorgestrel) supplied by GNH India

Levosert

Active Ingredient:
Levonorgestrel
Origin:
EU

Levosert (Levonorgestrel)

Levonorgestrel, the active ingredient in Levosert, is a progestin presented as an intrauterine system for intrauterine use. It provides long‑acting reversible contraception for women of reproductive age.
GNH India supplies Levosert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

  • Levosert, a levonorgestrel‑releasing intrauterine system, is used within the hormonal contraceptive pathway for long‑acting reversible contraception.
  • Contraception: provides effective prevention of pregnancy for up to five years.
  • Menstrual regulation: reduces menstrual blood loss and can improve cycle regularity.
  • Endometrial protection: suppresses endometrial proliferation during use.

How It Works

  • Levonorgestrel is released locally from the intrauterine system, where it binds to progesterone receptors in the cervical mucus, endometrium, and hypothalamic‑pituitary axis. This action thickens cervical mucus, inhibits endometrial growth, and can suppress ovulation, collectively preventing fertilisation and implantation.

Side Effects

Levosert may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Irregular bleeding or spotting
  • Amenorrhea (absence of periods)
  • Cramping or pelvic pain
  • Headache
  • Breast tenderness
  • Nausea

Serious or Rare Side Effects

  • Uterine perforation during insertion
  • Pelvic inflammatory disease
  • Ectopic pregnancy if contraception fails
  • Device expulsion
  • Severe allergic reaction
  • Hormone‑related thromboembolic events

Precautions & Warnings

  • Before using Levosert, certain precautions should be observed to ensure safety and effectiveness.
  • Screen for pregnancy: confirm the patient is not pregnant prior to insertion.
  • Assess uterine anatomy: evaluate for fibroids, septa, or other abnormalities.
  • Monitor for infection: advise patients to report fever, unusual discharge, or pelvic pain.
  • Avoid in active pelvic infection: postpone insertion until infection resolves.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levosert can interact with other medicines that affect hormone metabolism or uterine environment.

Major Interactions (Avoid)

  • Enzyme inducers (e.g., rifampin): may reduce levonorgestrel efficacy.
  • Anticonvulsants (e.g., carbamazepine): may lower hormone levels and increase failure risk.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., tetracycline): possible slight reduction in contraceptive effect.
  • Antifungal agents (e.g., ketoconazole): may increase levonorgestrel concentrations.
  • Herbal supplements (e.g., St. John’s wort): may decrease hormonal effectiveness.

Frequently Asked Questions

Levosert is a levonorgestrel‑releasing intrauterine system indicated for long‑acting reversible contraception. It provides continuous birth control for up to five years and can also help manage menstrual bleeding patterns.

Levonorgestrel released from the device acts locally on the cervix, endometrium, and hypothalamic‑pituitary axis. It thickens cervical mucus, suppresses endometrial growth, and may inhibit ovulation, together preventing fertilisation and implantation.

Levosert is supplied as a pre‑loaded intrauterine system. The specific dose and duration are determined by the prescribing clinician based on the patient’s medical history and contraceptive needs.

Levosert is intended for use in women who are not pregnant. If pregnancy occurs, the device should be removed. Limited data exist for breastfeeding; clinicians should weigh benefits and risks before use.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Levosert delivers levonorgestrel at a similar rate to other levonorgestrel‑releasing IUDs but is marketed in the EU. Its efficacy, safety profile, and duration of up to five years are comparable to other approved hormonal intrauterine devices.

Store Levosert at room temperature, below 25 °C, in its original sealed packaging. Protect it from moisture, direct sunlight, and extreme temperatures to maintain device integrity before insertion.

Levosert is inserted by a trained healthcare professional into the uterine cavity using a sterile applicator. The procedure is performed in a clinical setting following standard aseptic techniques.

Serious risks include uterine perforation during insertion, pelvic inflammatory disease, device expulsion, and, in rare cases, ectopic pregnancy if contraceptive failure occurs. Prompt medical attention is required if symptoms arise.

Levosert is contraindicated in women who are currently pregnant, have active pelvic infections, unexplained vaginal bleeding, uterine abnormalities that preclude device placement, or known hypersensitivity to levonorgestrel or device components.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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