Product image of Levosert (Levonorgestrel) supplied by GNH India

Levosert

Active Ingredient:
Levonorgestrel
Origin:
EU

Levosert (Levonorgestrel)

Levonorgestrel, the active ingredient in Levosert, is a progestogen presented as a 52 mg intrauterine system for intrauterine use. It provides long‑acting reversible contraception for women of reproductive age.

GNH India supplies Levosert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

  • Levosert is a hormonal intrauterine system used for contraception in women of reproductive age.
  • Contraception: Provides long‑acting reversible contraception to prevent pregnancy.
  • Menstrual regulation: Reduces heavy menstrual bleeding associated with hormonal contraception.
  • Endometrial suppression: Inhibits endometrial proliferation to maintain contraceptive efficacy.

How It Works

  • Levonorgestrel is continuously released from the intrauterine system, where it thickens cervical mucus, impairs sperm motility and function, and suppresses endometrial growth. The local hormone levels may also inhibit ovulation in some cycles, collectively preventing fertilization and implantation.

Side Effects

Levosert may cause a range of local and systemic reactions after insertion.

Common Side Effects

  • Irregular bleeding or spotting during the first months.
  • Amenorrhea after continued use.
  • Cramping or pelvic pain at insertion.
  • Headache or mild nausea.
  • Breast tenderness.
  • Vaginal discharge.

Serious or Rare Side Effects

  • Uterine perforation during insertion.
  • Expulsion of the device.
  • Pelvic inflammatory infection.
  • Ectopic pregnancy if contraception fails.
  • Allergic reaction to device components.
  • Severe abdominal pain requiring medical evaluation.

Precautions & Warnings

  • Before using Levosert, clinicians should assess patient suitability and counsel on potential risks.
  • Contraindications: Pregnancy, known or suspected uterine anomalies, active pelvic infection, or breast cancer.
  • Screening: Verify negative pregnancy test prior to insertion.
  • Follow‑up: Check device position 4–6 weeks after placement.
  • Bleeding changes: Counsel patients that irregular bleeding is common initially.
  • Concurrent hormonal therapy: Avoid overlapping use of other hormonal contraceptives.
  • Store at room temperature: Keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levosert has limited systemic absorption, but certain drugs can affect levonorgestrel levels.

Major Interactions (Avoid)

  • Rifampicin or other strong enzyme inducers: may reduce levonorgestrel efficacy.
  • Anticonvulsants such as carbamazepine, phenytoin: can lower hormone concentrations.
  • Mifepristone: may antagonize progestogenic activity.

Moderate Interactions (Monitor Closely)

  • St. John’s wort: may decrease levonorgestrel levels.
  • Azole antifungals (ketoconazole, itraconazole): may increase hormone exposure.
  • HIV protease inhibitors: potential alteration of hormone metabolism requiring monitoring.

Frequently Asked Questions

Levosert is a levonorgestrel‑releasing intrauterine system indicated for long‑acting reversible contraception in women of reproductive age. It provides continuous hormone delivery within the uterus to prevent pregnancy for up to several years.

Levonorgestrel released from the intrauterine system thickens cervical mucus, reduces sperm motility, and suppresses the growth of the uterine lining. In some cycles it may also inhibit ovulation, together preventing fertilisation and implantation.

Levosert is supplied as a pre‑loaded 52 mg intrauterine system. The exact dosing regimen, including insertion timing and duration of use, is determined by the prescribing clinician based on individual patient needs and regulatory guidelines.

Levosert is contraindicated in pregnancy and must not be inserted in a pregnant woman. Women who become pregnant while the device is in place should have it removed. Limited data exist for breastfeeding; clinicians should weigh benefits against potential risks.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Compared with oral or injectable progestogens, Levosert offers continuous, low‑dose hormone release directly within the uterus, eliminating daily adherence requirements. It typically provides longer protection (up to 5 years) and fewer systemic side effects than systemic hormonal methods.

Levosert should be stored at room temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight and extreme temperatures to maintain its integrity until insertion.

Levosert is inserted by a trained healthcare professional into the uterine cavity using a specialized inserter. The procedure is performed in a clinical setting under aseptic conditions, and the device remains in place for the approved duration without the need for daily dosing.

Serious risks include uterine perforation during insertion, device expulsion, pelvic inflammatory infection, and the rare possibility of ectopic pregnancy if contraceptive failure occurs. Prompt medical evaluation is required if severe abdominal pain, abnormal bleeding or signs of infection develop.

Levosert is contraindicated in women who are pregnant, have known or suspected uterine anomalies, active pelvic infection, breast cancer, or a history of thromboembolic disorders. Women with unexplained vaginal bleeding should be evaluated before insertion.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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