Product image of Levosert (Levonorgestrel) supplied by GNH India

Levosert

Active Ingredient:
Levonorgestrel
Origin:
EU

Levosert (Levonorgestrel)

Levonorgestrel, the active ingredient in Levosert, is a progestogen presented as a 52 mg intrauterine system for intrauterine use. It provides long‑acting reversible contraception for women of reproductive age.
GNH India supplies Levosert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

  • Levosert, a levonorgestrel‑based intrauterine system, is used for hormonal contraceptive control.
  • Long‑acting reversible contraception: provides up to five years of pregnancy prevention without daily dosing.
  • Prevention of unintended pregnancy: continuously releases low‑dose levonorgestrel to inhibit fertilisation.
  • Management of menstrual bleeding: can reduce the volume of menstrual bleeding in some users.

How It Works

  • Levosert releases levonorgestrel at an approximate rate of 20 µg per day within the uterine cavity. The hormone thickens cervical mucus, impairs sperm motility and viability, suppresses endometrial proliferation, and may inhibit ovulation, collectively preventing fertilisation and implantation.

Side Effects

Levosert may cause a range of adverse reactions. Monitoring and prompt reporting of any symptoms are recommended.

Common Side Effects

  • Irregular bleeding or spotting
  • Amenorrhea (absence of periods)
  • Cervical discharge
  • Abdominal pain or cramps

Serious or Rare Side Effects

  • Uterine perforation
  • IUD expulsion
  • Pelvic inflammatory disease (rare)
  • Ectopic pregnancy (if pregnancy occurs)
  • Severe allergic reaction (rash, hives, swelling)

Precautions & Warnings

  • Before insertion of Levosert, certain precautions should be observed to ensure safety and effectiveness.
  • Screen for pregnancy: confirm the patient is not pregnant prior to insertion.
  • Assess uterine anatomy: perform ultrasound if abnormalities are suspected.
  • Check for active infection: treat any pelvic infection before placement.
  • Consider contraindications: avoid use in women with known or suspected malignancy, severe liver disease, or thrombophilia.
  • Counsel on follow‑up: schedule a post‑insertion check to verify correct positioning.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levosert may interact with other medicines that affect hormone metabolism or uterine environment.

Major Interactions (Avoid)

  • Enzyme‑inducing antiepileptics (e.g., carbamazepine, phenytoin): may reduce levonorgestrel efficacy.
  • Rifampicin: decreases hormone levels, compromising contraceptive effect.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., tetracycline): may slightly lower contraceptive reliability.
  • Antifungal azoles (e.g., ketoconazole): can increase levonorgestrel concentrations.
  • Herbal supplements such as St. John’s wort: may reduce hormonal effectiveness.

Frequently Asked Questions

Levosert is an intrauterine system that provides long‑acting reversible contraception. It releases levonorgestrel continuously to prevent pregnancy for up to five years, offering a convenient alternative to daily hormonal methods.

Levonorgestrel released from Levosert thickens cervical mucus, reduces sperm motility, suppresses the growth of the uterine lining, and may inhibit ovulation. These combined actions create an environment that prevents fertilisation and implantation.

Levosert contains a total of 52 mg of levonorgestrel, delivering about 20 µg per day. The exact dosing schedule and insertion timing are determined by the prescribing healthcare professional based on individual patient needs.

Levosert is intended for use in women who are not pregnant. If pregnancy occurs, the device should be removed promptly. Limited data are available for breastfeeding; clinicians usually assess risks and benefits before recommending use.

To order Levosert, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Levosert delivers a similar low‑dose levonorgestrel release as other IUDs such as Mirena, but it is approved for up to five years of use. Its design and release profile may differ slightly, offering clinicians an additional option based on patient preference and regulatory status.

Levosert should be stored at ambient temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight and extreme temperature fluctuations to maintain its integrity until insertion.

Levosert is inserted by a qualified healthcare professional into the uterine cavity using a specialized inserter. The procedure is performed in a clinical setting under sterile conditions, and patients are advised to schedule a follow‑up visit to confirm correct placement.

Serious risks include uterine perforation during insertion, expulsion of the device, pelvic inflammatory disease, and, in rare cases, ectopic pregnancy if conception occurs. Prompt medical attention is required if severe abdominal pain, abnormal bleeding, or signs of infection develop.

Levosert is contraindicated in women who are pregnant, have active pelvic infections, known or suspected uterine or cervical cancer, severe liver disease, unexplained vaginal bleeding, or a history of uterine perforation. A thorough medical evaluation is essential before placement.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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