Product image of Levosert One (Levonorgestrel) supplied by GNH India

Levosert One

Active Ingredient:
Levonorgestrel
Origin:
EU

Levosert One (Levonorgestrel)

Levonorgestrel, the active ingredient in Levosert One, is a progestin presented as an intrauterine system for intrauterine use. It provides long‑acting reversible contraception and prevents pregnancy in women of reproductive age.

GNH India supplies Levosert One as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

Levonorgestrel is a progestin used in hormonal contraception to prevent pregnancy.

  • Long‑acting reversible contraception: provides sustained contraceptive effect when placed intrauterinely.
  • Prevention of pregnancy: blocks ovulation and fertilisation in women of reproductive age.
  • Hormonal contraceptive therapy: offers a non‑daily, highly effective birth‑control option.

How It Works

  • Levonorgestrel binds to progesterone receptors in the hypothalamus and pituitary, suppressing the luteinizing hormone surge and thereby inhibiting ovulation. It also thickens cervical mucus, reducing sperm penetration, and induces endometrial changes that diminish the likelihood of implantation.

Side Effects

Levosert One may cause a range of adverse reactions.

Common Side Effects

  • Irregular vaginal bleeding or spotting.
  • Amenorrhea (absence of periods).
  • Pelvic or abdominal cramping.
  • Device expulsion.
  • Headache.

Serious or Rare Side Effects

  • Uterine perforation during insertion.
  • Pelvic inflammatory infection.
  • Ectopic pregnancy if contraception fails.
  • Severe allergic reaction (anaphylaxis).
  • Thromboembolic events (rare).

Precautions & Warnings

Before insertion and during use, certain precautions should be observed.

  • Screen for uterine abnormalities: perform pelvic exam and ultrasound prior to insertion.
  • Avoid in active pelvic infection: postpone insertion until infection resolves.
  • Contraindicated in pregnancy: product is classified as Category X.
  • Monitor for device expulsion: check strings regularly and seek medical advice if expelled.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel may interact with other medicines, affecting its efficacy.

Major Interactions (Avoid)

  • Enzyme‑inducing anticonvulsants (e.g., carbamazepine): may reduce contraceptive effectiveness.
  • Rifampin: can lower levonorgestrel plasma levels.
  • Antiretroviral efavirenz: may decrease hormonal protection.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., tetracycline): may slightly diminish efficacy.
  • St. John’s wort (herbal supplement): may reduce hormone concentrations.
  • Azole antifungals (e.g., ketoconazole): may increase levonorgestrel levels, requiring monitoring.

Frequently Asked Questions

Levosert One is an intrauterine system that delivers levonorgestrel for long‑acting reversible contraception. It is intended to prevent pregnancy in women of reproductive age by providing continuous hormonal protection for several years.

Levonorgestrel released from the intrauterine system suppresses ovulation, thickens cervical mucus to block sperm entry, and alters the endometrial lining, making it less suitable for implantation. These combined actions provide effective contraception.

The dosing regimen for Levosert One is determined by the prescribing clinician based on the product’s approved specifications. The device is inserted once and provides contraceptive protection for the duration approved by regulatory authorities.

Levosert One is contraindicated in pregnancy (Category X) and should not be inserted in pregnant women. Women who become pregnant while using the device should seek medical advice. Limited data are available for breastfeeding; clinicians should assess risks and benefits.

To order Levosert One, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Compared with daily oral progestins or combined pills, Levosert One offers a single‑procedure, multi‑year contraceptive solution, eliminating the need for daily adherence. Its efficacy is comparable to other long‑acting reversible methods such as copper IUDs, while providing additional menstrual benefits.

Levosert One should be stored at room temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight and extreme temperatures to maintain its integrity until insertion.

Levosert One is a sterile intrauterine system inserted by a qualified healthcare professional into the uterine cavity through the cervical canal. The procedure is performed in a clinical setting under aseptic conditions.

Serious risks include uterine perforation during insertion, pelvic inflammatory infection, ectopic pregnancy if contraception fails, and rare allergic reactions. Prompt medical evaluation is essential if severe abdominal pain, fever, or unusual bleeding occurs.

Women with active pelvic infection, known or suspected uterine abnormalities, current pregnancy, or a history of severe allergic reaction to levonorgestrel should not use Levosert One. Clinicians should also consider contraindications such as certain cancers or unexplained vaginal bleeding.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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