Product image of Levosert Shi (Levonorgestrel) supplied by GNH India

Levosert Shi

Active Ingredient:
Levonorgestrel
Origin:
EU

Levosert Shi (Levonorgestrel)

Levonorgestrel, the active ingredient in Levosert Shi, is a progestin presented as an intrauterine system for intrauterine use. It provides long‑acting contraception and is also indicated for the management of heavy menstrual bleeding in women of reproductive age.

GNH India supplies Levosert Shi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing regulatory‑approved batches and supporting import documentation for global markets. All shipments adhere to WHO GMP standards and are tracked through secure logistics channels.

Manufacturer / TM Owner

Gedeon Richter Plc.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Levonorgestrel, delivered via an intrauterine system, is used in hormonal contraceptive and menstrual‑bleeding management pathways.

  • Contraception: long‑acting prevention of pregnancy for up to five years.
  • Heavy menstrual bleeding: reduction of menstrual blood loss and improvement of anemia.
  • Estrogen‑free contraception: suitable for women who have contraindications to estrogen‑containing methods.

How It Works

  • Levonorgestrel released from the intrauterine system binds to progesterone receptors in the endometrium, cervical mucus, and hypothalamic‑pituitary axis. This suppresses ovulation, thickens cervical mucus to impede sperm passage, and induces endometrial atrophy, thereby preventing implantation and reducing menstrual blood loss.

Side Effects

Levosert Shi may cause a range of adverse reactions. Common side effects are usually mild and transient, while serious or rare events require prompt medical attention.

Common Side Effects

  • Irregular bleeding or spotting.
  • Amenorrhea (absence of periods).
  • Abdominal or pelvic discomfort.
  • Breast tenderness.
  • Headache.

Serious or Rare Side Effects

  • Pelvic inflammatory disease.
  • Device expulsion or malposition.
  • Uterine perforation during insertion.
  • Severe allergic reaction (e.g., rash, swelling).
  • Thromboembolic events (rare).

Precautions & Warnings

Before insertion of Levosert Shi, clinicians should observe several safety measures.

  • Screen for contraindications: ensure no active pelvic infection or malignancy.
  • Assess uterine size and shape: confirm suitability for intrauterine placement.
  • Avoid insertion during pregnancy: verify negative pregnancy test.
  • Monitor for device displacement: schedule follow‑up examinations.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel released from an intrauterine system has limited systemic exposure, yet certain drugs can affect its efficacy.

Major Interactions (Avoid)

  • Enzyme inducers such as rifampin, carbamazepine, phenytoin, or St. John's wort, which may reduce hormone levels.
  • Antiepileptic drugs that increase hepatic metabolism of levonorgestrel.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., griseofulvin) that may modestly lower hormone concentrations.
  • Antifungal agents like ketoconazole that can alter steroid metabolism.
  • HIV protease inhibitors that may affect hormonal activity.

Frequently Asked Questions

Levosert Shi is an intrauterine system that releases levonorgestrel to provide long‑acting contraception and to reduce heavy menstrual bleeding in women of reproductive age.

Levonorgestrel binds to progesterone receptors, suppressing ovulation, thickening cervical mucus to block sperm, and causing endometrial changes that prevent implantation and lessen menstrual blood loss.

The dose and duration of Levosert Shi are determined by the prescribing clinician based on the approved product specifications and the patient’s clinical needs.

Levosert Shi is contraindicated in pregnancy. Women who become pregnant while using the device should seek medical advice. Limited data exist for breastfeeding; clinicians should evaluate risks and benefits individually.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Unlike daily oral pills, Levosert Shi offers continuous, low‑dose hormone release for up to five years, eliminating the need for daily adherence and providing additional benefit of reducing menstrual blood loss, which many oral progestins do not offer.

Store Levosert Shi at room temperature, preferably below 25 °C, in its original sealed packaging. Protect the device from moisture, extreme heat and direct sunlight to maintain its integrity.

Levosert Shi is inserted by a trained healthcare professional into the uterine cavity using a sterile applicator. The procedure is performed in a clinical setting under aseptic conditions.

Serious risks include pelvic inflammatory disease, uterine perforation during insertion, device expulsion or malposition, and rare thromboembolic events. Prompt medical evaluation is essential if any concerning symptoms arise.

Women with active pelvic infection, known or suspected uterine malignancy, unexplained vaginal bleeding, pregnancy, or a history of severe allergic reaction to levonorgestrel or device components should avoid using Levosert Shi.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Levonorgestrel

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT