Product image of Levosert Shi (Levonorgestrel) supplied by GNH India

Levosert Shi

Active Ingredient:
Levonorgestrel
Origin:
EU

Levosert Shi (Levonorgestrel)

Levonorgestrel, the active ingredient in Levosert Shi, is a progestin presented as an intrauterine system for intrauterine use. The device releases levonorgestrel locally over several years, providing reliable contraception for women of reproductive age and reducing menstrual bleeding.

GNH India supplies Levosert Shi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across all markets.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

Levosert Shi delivers levonorgestrel to the uterine cavity and is indicated for hormonal contraceptive and menstrual management pathways.

  • Contraception: prevents pregnancy in women of reproductive age through sustained hormone release.
  • Heavy menstrual bleeding: reduces menstrual blood loss and improves anemia associated with excessive bleeding.
  • Endometrial protection during estrogen therapy: prevents estrogen‑induced endometrial hyperplasia in women receiving combined hormone regimens.

How It Works

  • Levonorgestrel released from the intrauterine system binds to progesterone receptors in the endometrium, cervical mucus, and hypothalamic‑pituitary axis. This suppresses ovulation, thickens cervical mucus to impede sperm passage, and induces endometrial atrophy, creating an environment unsuitable for implantation. The localized delivery maintains effective concentrations within the uterus while minimizing systemic exposure.

Side Effects

Levosert Shi may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Irregular vaginal bleeding or spotting
  • Amenorrhea (absence of periods)
  • Pelvic or abdominal cramping
  • Breast tenderness

Serious or Rare Side Effects

  • Uterine perforation during insertion
  • Device expulsion or displacement
  • Severe allergic reaction (anaphylaxis)

Precautions & Warnings

Before using Levosert Shi, clinicians should observe several safety measures.

  • Pregnancy testing: confirm non‑pregnant status before device insertion.
  • Uterine evaluation: perform ultrasound to rule out anomalies or fibroids that may impede placement.
  • Infection screening: assess for active pelvic infection; treat before insertion.
  • Follow‑up visits: schedule post‑insertion checks to verify correct positioning.
  • Contraindications review: avoid use in women with known hypersensitivity to levonorgestrel or uterine malignancy.
  • Store at room temperature: keep the device in its original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levosert Shi can interact with other medicines that affect hormone metabolism.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin): may markedly reduce contraceptive efficacy.
  • Enzyme‑inducing antiepileptics: can accelerate levonorgestrel metabolism, increasing failure risk.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., tetracycline, metronidazole): may slightly lower hormone levels; advise backup contraception.
  • Antifungal azoles (e.g., ketoconazole): potential modest reduction in effectiveness.
  • Herbal supplements such as St. John’s wort: may diminish hormone exposure; monitor for breakthrough bleeding.

Frequently Asked Questions

Levosert Shi is an intrauterine system that provides levonorgestrel directly to the uterus. It is used primarily to prevent pregnancy in women of reproductive age and can also help manage heavy menstrual bleeding and protect the endometrium during estrogen therapy.

Levonorgestrel released from the device binds to progesterone receptors, suppressing ovulation, thickening cervical mucus to block sperm, and inducing endometrial atrophy. These combined actions create a uterine environment that prevents implantation and reduces menstrual blood loss.

Levosert Shi is supplied as a pre‑loaded intrauterine system that releases a fixed amount of levonorgestrel over several years. The exact dosing regimen is determined by the prescribing clinician based on the product’s specifications and the patient’s needs.

Levosert Shi is contraindicated in women who are pregnant; it must be inserted only after confirming a negative pregnancy test. Limited data exist for use while breastfeeding, so clinicians should evaluate the risk‑benefit profile and discuss alternatives with the patient.

To order Levosert Shi, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with oral progestin pills, Levosert Shi offers continuous, low‑dose hormone delivery without daily adherence. Unlike copper IUDs, it provides hormonal benefits such as reduced menstrual bleeding. Its efficacy, duration (up to several years), and localized action make it a convenient long‑acting reversible contraceptive option.

Levosert Shi should be stored at room temperature, ideally below 25 °C. Keep the device in its original sterile packaging, protect it from moisture, direct sunlight and extreme temperatures until the time of insertion by a qualified healthcare professional.

A trained clinician inserts Levosert Shi through the cervical canal into the uterine cavity using a specialized inserter. The procedure is performed in a clinical setting under aseptic conditions, and the device remains in place to release levonorgestrel for the approved duration.

Serious risks include uterine perforation during insertion, device expulsion or displacement, ectopic pregnancy if contraception fails, and severe allergic reactions such as anaphylaxis. Patients should be monitored for these events and instructed to seek immediate medical attention if symptoms arise.

Levosert Shi is not suitable for women with active pelvic infection, known hypersensitivity to levonorgestrel, uterine anomalies that prevent proper placement, current or suspected pregnancy, or a history of uterine or breast cancer. A thorough medical assessment is required before insertion.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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