Product image of Levosertone (Levonorgestrel) supplied by GNH India

Levosertone

Active Ingredient:
Levonorgestrel
Origin:
EU

Levosertone (Levonorgestrel)

Levonorgestrel, the active ingredient in Levosertone, is a progestin presented as an intrauterine system for intrauterine use. It provides long‑acting reversible contraception for women of reproductive age.

GNH India supplies Levosertone as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

Levosertone (levonorgestrel) is a hormonal contraceptive that works within the reproductive system.

  • Contraception: provides continuous birth control for women seeking reliable intrauterine contraception.
  • Heavy menstrual bleeding: reduces menstrual blood loss and improves cycle regularity.
  • Endometrial protection: offers protection against endometrial hyperplasia when combined with estrogen therapy.

How It Works

  • Levonorgestrel released from the intrauterine system binds to progesterone receptors in the ovary, suppressing the mid‑cycle luteinising hormone surge and thereby inhibiting ovulation. It also thickens cervical mucus, creating a barrier to sperm penetration, and induces endometrial changes that render the uterine lining unsuitable for implantation.

Side Effects

Levosertone may cause a range of adverse reactions, most of which are related to its local hormonal activity.

Common Side Effects

  • Irregular bleeding or spotting
  • Amenorrhea (absence of periods)
  • Pelvic or abdominal cramping
  • Dysmenorrhea (painful periods)
  • Headache
  • Breast tenderness

Serious or Rare Side Effects

  • Uterine perforation during insertion
  • Device expulsion or migration
  • Pelvic inflammatory infection
  • Ectopic pregnancy if contraception fails
  • Severe allergic reaction (rash, swelling)
  • Thromboembolic events (deep vein thrombosis, pulmonary embolism)

Precautions & Warnings

Before using Levosertone, certain safety considerations should be observed.

  • Pregnancy contraindication: do not insert in pregnant women.
  • Breastfeeding: discuss risks with a healthcare professional.
  • Pelvic infection: avoid insertion during active pelvic inflammatory disease.
  • Uterine anomalies: assess for fibroids or malformations that may affect placement.
  • Follow‑up: schedule post‑insertion check to confirm correct positioning.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levosertone can interact with other medicines that affect hormone metabolism.

Major Interactions (Avoid)

  • Rifampin, carbamazepine, phenytoin, phenobarbital: potent enzyme inducers that markedly reduce levonorgestrel levels.
  • St. John’s wort: herbal inducer that may compromise contraceptive efficacy.

Moderate Interactions (Monitor Closely)

  • Ketoconazole, itraconazole: antifungals that can increase levonorgestrel concentrations.
  • Efavirenz, nevirapine: antiretrovirals that may lower effectiveness.
  • Certain antibiotics (e.g., griseofulvin): may modestly affect hormone levels.
  • Anticonvulsants (e.g., valproate): require monitoring of contraceptive reliability.

Frequently Asked Questions

Levosertone is an intrauterine system that delivers levonorgestrel locally to provide long‑acting reversible contraception. It is also indicated for the treatment of heavy menstrual bleeding and for endometrial protection when combined with estrogen therapy.

Levonorgestrel released from the device binds to progesterone receptors, suppressing ovulation, thickening cervical mucus to block sperm entry, and inducing endometrial changes that prevent implantation. These combined actions create a highly effective contraceptive environment.

The dose of levonorgestrel released by Levosertone is pre‑determined by the manufacturer and is not adjusted by the patient. The prescribing clinician selects the appropriate product based on clinical guidelines and the patient’s individual needs.

Levosertone is contraindicated in pregnancy (Category X) and should not be inserted in pregnant women. For breastfeeding mothers, the benefits and risks should be discussed with a healthcare professional, as levonorgestrel does pass into breast milk in low amounts.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levosertone uses levonorgestrel, the same progestin found in many hormonal IUDs, offering comparable efficacy and safety profiles. Differences may lie in the amount of hormone released, device size, and approved duration of use, which should be evaluated by the prescriber based on patient preference and clinical factors.

Levosertone should be stored at ambient temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight and extreme temperature fluctuations to maintain its integrity until insertion.

Levosertone is inserted by a qualified healthcare professional into the uterine cavity through the cervix. The procedure is performed in a clinical setting under aseptic conditions, and the device remains in place for the duration specified by the manufacturer.

Serious risks include uterine perforation during insertion, device expulsion or migration, pelvic inflammatory infection, ectopic pregnancy if contraception fails, and rare allergic reactions. Prompt medical attention is required if any of these events are suspected.

Levosertone should not be used by women who are pregnant, have active pelvic infections, untreated cervical or uterine cancer, unexplained vaginal bleeding, or certain uterine abnormalities such as large fibroids that could impede placement.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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