Product image of Levosertone (Levonorgestrel) supplied by GNH India

Levosertone

Active Ingredient:
Levonorgestrel
Origin:
EU

Levosertone (Levonorgestrel)

Levonorgestrel, the active ingredient in Levosertone, is a progestogen (progestin) presented as an intrauterine system for intrauterine use. It prevents pregnancy and can be used to manage heavy menstrual bleeding.
GNH India supplies Levosertone as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

  • Levosertone, a levonorgestrel‑based intrauterine system, is used in hormonal contraceptive pathways and menstrual management.
  • Contraception: provides long‑term, reversible birth control for women of reproductive age.
  • Heavy menstrual bleeding: reduces menstrual blood loss and improves anemia associated with excessive bleeding.

How It Works

  • Levonorgestrel released from the intrauterine system acts locally on the endometrium and cervical mucus. It thickens cervical mucus to impede sperm passage, suppresses endometrial proliferation to reduce bleeding, and may inhibit ovulation by altering the hypothalamic‑pituitary‑ovarian axis, collectively preventing pregnancy.

Side Effects

Levosertone may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Irregular bleeding or spotting, especially during the first months.
  • Amenorrhea (absence of periods) after prolonged use.
  • Pelvic or uterine cramping after insertion.
  • Breast tenderness or mild hormonal changes.

Serious or Rare Side Effects

  • Pelvic inflammatory disease or uterine infection.
  • Uterine perforation during insertion.
  • Expulsion of the device requiring medical attention.

Precautions & Warnings

  • Before prescribing Levosertone, clinicians should consider several safety measures.
  • Screen for pregnancy: confirm the patient is not pregnant prior to insertion.
  • Assess uterine size and shape: verify suitability for an intrauterine system.
  • Review medical history: avoid use in active pelvic infection, uterine anomalies, or hormone‑sensitive cancers.
  • Monitor bleeding patterns: counsel patients on expected changes and when to seek care.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levosertone can interact with other medicines that affect hormone metabolism.

Major Interactions (Avoid)

  • Enzyme‑inducing anticonvulsants (e.g., carbamazepine, phenytoin): may reduce levonorgestrel efficacy.
  • Rifampin: can lower hormone levels and increase risk of contraceptive failure.
  • Protease inhibitor antiretrovirals: may alter levonorgestrel metabolism.

Moderate Interactions (Monitor Closely)

  • Azole antifungals (e.g., ketoconazole): may increase levonorgestrel concentrations.
  • Certain antibiotics (e.g., tetracycline): have minimal effect but should be monitored for any changes in bleeding.

Frequently Asked Questions

Levosertone is an intrauterine system that delivers levonorgestrel directly to the uterus. It is indicated for long‑term reversible contraception and for the management of heavy menstrual bleeding in women of reproductive age.

Levonorgestrel released from the device thickens cervical mucus, inhibits the growth of the endometrium, and may suppress ovulation. These actions together create an environment that prevents sperm penetration and reduces menstrual blood loss.

The dose of levonorgestrel in Levosertone is fixed by the manufacturer and the device is inserted by a qualified health professional. The prescribing clinician determines suitability and duration of use based on individual patient needs.

Levosertone is intended for use in women who are not pregnant. It should be removed if pregnancy occurs. Limited data are available on breastfeeding; clinicians should weigh benefits against potential risks and discuss options with the patient.

To order Levosertone, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with oral progestins or combined pills, Levosertone offers continuous low‑dose hormone release directly to the uterus, resulting in higher efficacy, fewer systemic side effects, and up to several years of contraception without daily adherence.

Levosertone should be stored at ambient temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight and extreme temperatures to maintain its integrity until insertion.

Levosertone is a sterile intrauterine system that is inserted by a trained clinician through the cervical canal into the uterine cavity. The procedure is performed in a clinical setting under aseptic conditions.

Serious risks include uterine perforation during insertion, pelvic inflammatory disease, device expulsion, and rare cases of ectopic pregnancy if contraception fails. Patients should seek immediate medical attention for severe abdominal pain, fever or abnormal bleeding.

Levosertone is contraindicated in women who are pregnant, have active pelvic infection, unexplained vaginal bleeding, uterine anomalies, known or suspected hormone‑dependent cancers, or who have had a recent uterine surgery that precludes IUS placement.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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