Product image of Levosimendan Accord (Levosimendan) supplied by GNH India

Levosimendan Accord

Active Ingredient:
Levosimendan
Origin:
EU

Levosimendan Accord (Levosimendan)

Levosimendan, the active ingredient in Levosimendan Accord, is a calcium sensitizer presented as an intravenous formulation for intravenous use. It enhances myocardial contractility and reduces cardiac preload and afterload, providing symptomatic relief in acute decompensated heart failure patients with severe left ventricular dysfunction.

GNH India supplies Levosimendan Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and specialty clinics worldwide, sourcing the product from EU‑authorized manufacturers. Our distribution network ensures timely delivery and regulatory compliance across multiple regions.

Manufacturer / TM Owner

Accord Healthcare Polska Sp. Z O.O.

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Indications & Clinical Uses

  • Levosimendan is used in the management of acute heart failure, acting as a calcium sensitizer to improve cardiac performance.
  • Acute decompensated heart failure: improves cardiac output and reduces symptoms of congestion.
  • Severe left ventricular failure: increases contractility in patients with markedly reduced ejection fraction.
  • Low cardiac output states: helps stabilize hemodynamics while definitive therapy is arranged.

How It Works

  • Levosimendan binds to troponin C in cardiac myocytes, increasing its sensitivity to calcium and thereby enhancing contractile force without raising intracellular calcium concentration. It also opens ATP‑sensitive potassium channels in vascular smooth muscle, producing vasodilation and reducing both preload and afterload, which together improve overall cardiac performance.

Side Effects

Levosimendan may be associated with several adverse reactions.

Common Side Effects

  • Headache
  • Hypotension
  • Nausea
  • Dizziness
  • Flushing
  • Palpitations

Serious or Rare Side Effects

  • Severe hypotension leading to syncope
  • Ventricular arrhythmias
  • Myocardial ischemia
  • Allergic skin reactions
  • Significant electrolyte disturbances (e.g., hypokalemia)
  • Elevated liver enzymes

Precautions & Warnings

  • Levosimendan requires careful monitoring and specific safety measures.
  • Monitor blood pressure: check regularly for hypotensive episodes.
  • Assess cardiac rhythm: watch for new or worsening arrhythmias.
  • Evaluate renal function: adjust use if renal impairment is present.
  • Review electrolyte status: especially potassium and magnesium levels.
  • Use with caution in recent myocardial infarction: risk of ischemia may be increased.
  • Store at controlled room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Levosimendan can interact with other cardiovascular agents, necessitating vigilance.

Major Interactions (Avoid)

  • Concomitant vasodilators (e.g., nitroglycerin) may cause profound hypotension.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole) can increase drug exposure.
  • Other calcium sensitizers may produce additive inotropic effects.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers may blunt desired hemodynamic response.
  • Loop diuretics can exacerbate electrolyte imbalances.
  • ACE inhibitors may increase the risk of hypotension when combined.

Frequently Asked Questions

Levosimendan Accord is indicated for the treatment of acute decompensated heart failure, a severe form of heart failure where the heart cannot pump enough blood to meet the body's needs, leading to symptoms such as shortness of breath, fluid buildup, and low blood pressure.

Levosimendan enhances the sensitivity of cardiac troponin C to calcium, which strengthens heart muscle contraction without increasing intracellular calcium levels. It also opens ATP‑sensitive potassium channels in blood vessels, causing vasodilation that reduces the workload on the heart.

The specific dosage and infusion rate of Levosimendan Accord are determined by the prescribing clinician based on the patient’s clinical condition, response, and tolerability. Healthcare professionals follow established guidelines and adjust the regimen as needed.

Safety data for levosimendan in pregnancy and lactation are limited. It should only be used if the potential benefits justify any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Levosimendan Accord, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Levosimendan differs from traditional catecholamine inotropes by increasing contractility without raising intracellular calcium, which may reduce the risk of arrhythmias. It also provides vasodilatory effects, whereas many other inotropes primarily increase heart rate and contractility, potentially leading to higher myocardial oxygen consumption.

Levosimendan Accord should be stored at controlled room temperature, typically below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and avoid freezing to maintain stability.

Levosimendan Accord is given by intravenous infusion under the supervision of a qualified healthcare professional. The infusion is usually started with a loading dose followed by a maintenance infusion, with continuous monitoring of vital signs and cardiac function.

Serious risks include severe hypotension, which can lead to fainting or organ hypoperfusion, and ventricular arrhythmias that may be life‑threatening. Patients should be closely monitored for signs of myocardial ischemia and significant electrolyte disturbances during treatment.

Levosimendan Accord is contraindicated in patients with known hypersensitivity to levosimendan or any of its excipients, and it should be used with caution in individuals with recent myocardial infarction, severe hypotension, or uncontrolled arrhythmias. Clinical judgment is essential to determine suitability.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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