Product image of Levosimendan Altan (Levosimendan) supplied by GNH India

Levosimendan Altan

Active Ingredient:
Levosimendan
Origin:
EU

Levosimendan Altan (Levosimendan)

Levosimendan, the active ingredient in Levosimendan Altan, is a calcium sensitizer/inodilator presented as an intravenous solution for intravenous use. It improves cardiac contractility in patients with acute decompensated heart failure.

GNH India supplies Levosimendan Altan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Altan Pharma Ltd

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Indications & Clinical Uses

  • Levosimendan is employed in the management of heart‑failure related conditions where enhanced cardiac output is required.
  • Acute decompensated heart failure: improves hemodynamics and reduces symptoms of congestion.
  • Low cardiac output syndrome (post‑cardiac surgery): supports myocardial performance and systemic perfusion.
  • Cardiogenic shock (adjunct therapy): may augment cardiac output when conventional measures are insufficient.

How It Works

  • Levosimendan binds to cardiac troponin C, increasing its sensitivity to calcium and thereby enhancing contractile force without raising intracellular calcium levels. Simultaneously, it opens ATP‑sensitive potassium channels in vascular smooth muscle, causing vasodilation and reducing after‑load, which together improve overall cardiac output.

Side Effects

Levosimendan may be associated with several adverse reactions that vary in frequency and severity.

Common Side Effects

  • Headache
  • Hypotension
  • Nausea
  • Flushing
  • Tachycardia
  • Arrhythmia

Serious or Rare Side Effects

  • Severe hypotension leading to syncope
  • Ventricular arrhythmias
  • Myocardial ischemia
  • Anaphylactic or severe allergic reactions
  • Elevated liver enzymes
  • Acute renal failure

Precautions & Warnings

  • When using Levosimendan, clinicians should consider several safety measures.
  • Monitor blood pressure: avoid excessive hypotension.
  • Assess cardiac rhythm: watch for new or worsening arrhythmias.
  • Evaluate renal and hepatic function: adjust use in impairment.
  • Avoid concurrent strong vasodilators: may potentiate hypotensive effects.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levosimendan can interact with other medications, requiring careful management.

Major Interactions (Avoid)

  • Concurrent use with other potent vasodilators (e.g., nitroglycerin) may cause severe hypotension.
  • Strong CYP450 inhibitors (e.g., ketoconazole) can increase plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may blunt desired increase in cardiac output.
  • Diuretics: may exacerbate electrolyte disturbances.
  • Anticoagulants: monitor for bleeding if hypotension occurs.

Frequently Asked Questions

Levosimendan Altan is used to treat acute decompensated heart failure and other conditions where improving cardiac contractility and reducing vascular resistance are needed, such as low cardiac output after cardiac surgery.

Levosimendan increases the sensitivity of troponin C to calcium, enhancing heart muscle contraction without raising calcium levels, and opens ATP‑sensitive potassium channels in blood vessels, causing vasodilation and lowering after‑load.

The dosing regimen for Levosimendan Altan is determined by the prescribing clinician based on the patient’s clinical status, weight, and response; it is administered intravenously under medical supervision.

Safety data for Levosimendan in pregnancy and lactation are limited; it should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Compared with other inodilators, Levosimendan uniquely combines calcium sensitization with potassium‑channel‑mediated vasodilation, offering a sustained hemodynamic effect that may last beyond the infusion period, whereas some alternatives act primarily through catecholamine pathways.

Levosimendan Altan should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. It should be kept in its original packaging until ready for preparation and administration.

Levosimendan Altan is given as an intravenous infusion, typically initiated with a loading dose followed by a continuous infusion, performed in a monitored clinical setting by qualified healthcare personnel.

The most serious risks include severe hypotension, ventricular arrhythmias, myocardial ischemia, and rare cases of anaphylactic reactions; patients should be closely monitored for hemodynamic changes and cardiac rhythm during therapy.

Levosimendan is contraindicated in patients with known hypersensitivity to the drug, those with severe hypotension unresponsive to treatment, and individuals receiving strong vasodilators that could precipitate dangerous blood‑pressure drops.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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