Product image of Levosulpirida Stada (Levosulpiride) supplied by GNH India

Levosulpirida Stada

Active Ingredient:
Levosulpiride
Origin:
EU

Levosulpirida Stada (Levosulpiride)

Levosulpiride, the active ingredient in Levosulpirida Stada, is a benzamide derivative presented as an oral formulation for oral use. It treats schizophrenia, depressive disorders, functional dyspepsia and gastroesophageal reflux disease in adult patients.

GNH India supplies Levosulpirida Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and research institutions worldwide.

Manufacturer / TM Owner

Laboratorio Stada, S.L.

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Indications & Clinical Uses

Levosulpiride is used in psychiatric and gastrointestinal disorders that involve dopamine dysregulation.

  • Schizophrenia: alleviates positive and negative symptoms in adult patients.
  • Depressive disorders: augments antidepressant response and improves mood.
  • Functional dyspepsia: enhances gastric motility and reduces dyspeptic discomfort.
  • Gastroesophageal reflux disease: increases lower esophageal sphincter tone and decreases reflux episodes.

How It Works

  • Levosulpiride selectively antagonizes dopamine D2 receptors in the central nervous system, reducing dopaminergic neurotransmission associated with psychotic symptoms. Its peripheral D2 blockade also exerts prokinetic activity by stimulating gastrointestinal motility, thereby improving gastric emptying and lower esophageal sphincter function.

Side Effects

Levosulpiride may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Nausea
  • Headache
  • Dizziness
  • Dry mouth

Serious or Rare Side Effects

  • Extrapyramidal symptoms such as akathisia or dystonia
  • Neuroleptic malignant syndrome
  • Severe allergic reactions, including anaphylaxis

Precautions & Warnings

Use of levosulpiride requires careful consideration of several safety aspects.

  • Pregnancy: safety not established; avoid unless clearly needed.
  • Breastfeeding: unknown excretion; consider risk versus benefit.
  • Renal impairment: dose adjustment may be required.
  • Hepatic impairment: use with caution and monitor liver function.
  • Elderly patients: increased sensitivity to central effects; start at low dose.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Levosulpiride can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong D2 antagonists (e.g., haloperidol): heightened risk of extrapyramidal effects.
  • Monoamine oxidase inhibitors: potential for hypertensive crisis.
  • QT‑prolonging agents (e.g., quinidine): additive cardiac risk.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine): may increase levosulpiride plasma levels.
  • Central nervous system depressants (e.g., benzodiazepines): enhanced sedation.

Frequently Asked Questions

Levosulpirida Stada is prescribed for adult patients with schizophrenia, depressive disorders, functional dyspepsia and gastroesophageal reflux disease. In psychiatry it helps control psychotic symptoms, while in gastro‑intestinal practice it improves gastric motility and reduces reflux episodes.

Levosulpiride acts as a selective dopamine D2‑receptor antagonist. By blocking D2 receptors in the brain it reduces dopaminergic activity that contributes to psychosis. Peripherally, the same antagonism stimulates gastrointestinal smooth‑muscle activity, providing a prokinetic effect that aids digestion and lower‑esophageal sphincter tone.

The exact dose is set by the prescribing clinician based on the specific indication, severity of disease, patient age, renal and hepatic function, and any concomitant medications. No universal dosing regimen is provided; the prescriber tailors therapy to each individual’s clinical situation.

Safety data for levosulpiride in pregnancy and lactation are limited. It is generally advised to avoid use unless the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare professional.

To request Levosulpirida Stada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levosulpiride is an atypical antipsychotic that selectively blocks dopamine D2 receptors while having minimal affinity for serotonin receptors. Compared with many typical antipsychotics, it tends to produce fewer metabolic side effects but may still cause extrapyramidal symptoms. Its additional prokinetic activity makes it useful for certain gastrointestinal conditions, a feature not shared by most other antipsychotics.

Levosulpirida Stada should be stored at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and store it out of reach of children. Do not refrigerate or freeze the tablets.

Levosulpirida Stada is taken orally. The tablets should be swallowed whole with a glass of water and can be taken with or without food, unless the prescriber advises otherwise. Patients should follow the dosing schedule provided by their healthcare professional.

Serious adverse reactions include extrapyramidal symptoms such as akathisia or dystonia, neuroleptic malignant syndrome—a rare but life‑threatening condition—and severe allergic responses like anaphylaxis. Prompt medical attention is required if any of these events occur.

Levosulpirida Stada is contraindicated in patients with known hypersensitivity to levosulpiride or any excipients, those taking monoamine oxidase inhibitors, and individuals with uncontrolled cardiac arrhythmias or severe QT prolongation. Caution is also advised for patients with significant renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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