Product image of Levosulpiride Aristo (Levosulpiride) supplied by GNH India

Levosulpiride Aristo

Active Ingredient:
Levosulpiride
Origin:
EU

Levosulpiride Aristo (Levosulpiride)

Levosulpiride, the active ingredient in Levosulpiride Aristo, is a benzamide derivative presented as an oral tablet for oral use. It is employed in the management of certain psychiatric conditions and functional gastrointestinal disorders in adult patients. The medication acts by selectively blocking dopamine D2 receptors, which can help alleviate symptoms of psychosis and improve gastrointestinal motility.

GNH India supplies Levosulpiride Aristo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aristo Pharma Gmbh (Art 57)

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Indications & Clinical Uses

Levosulpiride is used in several psychiatric and gastrointestinal pathways.

  • Schizophrenia: reduces psychotic symptoms by antagonizing dopamine D2 receptors.
  • Depressive disorders: may improve mood symptoms when used as adjunct therapy.
  • Anxiety disorders: helps alleviate anxiety through dopaminergic modulation.
  • Functional dyspepsia: enhances gastric motility, relieving upper abdominal discomfort.
  • Gastroparesis: improves gastric emptying in patients with delayed gastric transit.

How It Works

  • Levosulpiride selectively blocks dopamine D2 receptors in the central nervous system, decreasing dopaminergic neurotransmission that underlies psychotic symptoms. The same dopaminergic blockade in the gastrointestinal tract reduces inhibitory dopamine tone, thereby enhancing acetylcholine release and promoting coordinated smooth‑muscle contractions that improve gastric motility.

Side Effects

Levosulpiride may cause a range of adverse reactions.

Common Side Effects

  • Extrapyramidal symptoms (e.g., tremor, rigidity)
  • Drowsiness or fatigue
  • Dry mouth
  • Weight gain
  • Nausea or vomiting
  • Diarrhea

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome
  • Severe hyperprolactinemia
  • Tardive dyskinesia
  • Seizures
  • Cardiac arrhythmias (QT prolongation)
  • Severe allergic reactions (e.g., Stevens‑Johnson syndrome)

Precautions & Warnings

Levosulpiride requires careful monitoring and patient education.

  • Monitor psychiatric status: assess symptom changes regularly.
  • Assess gastrointestinal function: watch for worsening dyspepsia.
  • Avoid abrupt discontinuation: taper under medical supervision.
  • Caution in hepatic impairment: consider dose adjustment if needed.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Levosulpiride can interact with several drug classes.

Major Interactions (Avoid)

  • Antipsychotics (e.g., haloperidol): additive dopamine blockade may increase extrapyramidal effects.
  • CYP450 inhibitors (e.g., ketoconazole): may raise levosulpiride plasma levels.
  • QT‑prolonging drugs: combined use can increase risk of cardiac arrhythmia.

Moderate Interactions (Monitor Closely)

  • Anticholinergics: may reduce gastrointestinal prokinetic effect.
  • Alcohol: can enhance central nervous system depression.
  • Other dopamine antagonists: may potentiate side‑effects such as prolactin elevation.

Frequently Asked Questions

Levosulpiride Aristo is prescribed for several recognized indications, including schizophrenia, depressive and anxiety disorders, functional dyspepsia, and gastroparesis. In psychiatric conditions it helps control psychotic and mood symptoms, while in gastrointestinal disorders it improves gastric motility and symptom relief.

Levosulpiride works by selectively antagonizing dopamine D2 receptors. In the brain this reduces dopaminergic over‑activity that contributes to psychosis, and in the gut it diminishes dopamine‑mediated inhibition of smooth‑muscle activity, thereby enhancing gastric emptying and overall motility.

The appropriate dose of Levosulpiride Aristo is determined by the prescribing clinician based on the specific indication, patient age, renal function, and treatment response. Dosage regimens can vary widely, so patients should follow the exact instructions provided by their healthcare professional.

Safety data for levosulpiride in pregnancy and lactation are limited, and the product is generally not recommended unless the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their physician.

To request Levosulpiride Aristo, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levosulpiride belongs to the benzamide class and differs from typical antipsychotics by having a more selective D2 antagonism and a notable prokinetic effect. Compared with broader‑spectrum agents, it may present a lower risk of metabolic side effects but still carries the potential for extrapyramidal symptoms and prolactin elevation.

Levosulpiride Aristo should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Maintaining a stable, room‑temperature environment helps preserve the tablet’s potency and prevents degradation.

Levosulpiride Aristo is taken orally, usually with or without food as directed by the prescriber. The tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically advised by a healthcare professional.

Serious risks include neuroleptic malignant syndrome, severe hyperprolactinemia, tardive dyskinesia, seizures, and cardiac arrhythmias such as QT prolongation. Patients should be monitored for early signs of these conditions, and any concerning symptoms should prompt immediate medical evaluation.

Levosulpiride Aristo is contraindicated in individuals with known hypersensitivity to levosulpiride or other benzamide derivatives, and in patients with severe hepatic impairment unless a specialist advises otherwise. Caution is also advised for those with a history of cardiac arrhythmias, uncontrolled epilepsy, or prolactin‑dependent tumors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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