Product image of Levosulpiride Eg (Levosulpiride) supplied by GNH India

Levosulpiride Eg

Active Ingredient:
Levosulpiride
Origin:
EU

Levosulpiride Eg (Levosulpiride)

Levosulpiride, the active ingredient in Levosulpiride Eg, is a benzamide antipsychotic presented as an oral tablet for oral use. It is employed in the management of psychiatric conditions such as schizophrenia, depressive and anxiety disorders, as well as gastrointestinal motility disorders including functional dyspepsia and gastroparesis.

GNH India supplies Levosulpiride Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and providing regulatory‑compliant documentation for global distribution.

Manufacturer / TM Owner

Epifarma S.R.L.

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Indications & Clinical Uses

  • Levosulpiride is indicated for several psychiatric and gastrointestinal disorders that involve dopaminergic pathways.
  • Schizophrenia: reduces positive symptoms and improves overall psychotic profile.
  • Depressive disorders: augments antidepressant response in patients with depressive symptoms.
  • Anxiety disorders: alleviates anxiety manifestations associated with dopaminergic dysregulation.
  • Functional dyspepsia: enhances gastric emptying and relieves upper‑abdominal discomfort.
  • Gastroparesis: promotes gastric motility and reduces nausea in delayed gastric emptying.

How It Works

  • Levosulpiride selectively antagonizes dopamine D2 receptors in the central nervous system, which diminishes dopaminergic hyperactivity responsible for psychotic symptoms. The same D2 blockade in the gastrointestinal tract enhances cholinergic activity, leading to increased gastric motility and accelerated gastric emptying, thereby providing prokinetic effects.

Side Effects

Levosulpiride may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Drowsiness
  • Dry mouth
  • Constipation
  • Weight gain
  • Increased prolactin levels
  • Nausea

Serious or Rare Side Effects

  • Extrapyramidal symptoms
  • Tardive dyskinesia
  • Neuroleptic malignant syndrome
  • Severe hyperprolactinemia
  • Cardiac arrhythmias
  • Severe allergic reactions (anaphylaxis)

Precautions & Warnings

  • Levosulpiride requires careful consideration of patient‑specific factors and monitoring for adverse events.
  • Pregnancy: safety not established; avoid unless benefits outweigh risks.
  • Breastfeeding: unknown; consider discontinuation.
  • Elderly: monitor for increased sensitivity to side effects.
  • Renal impairment: dose adjustment may be required.
  • Concomitant CNS depressants: may enhance sedation.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Levosulpiride can interact with other medicines, necessitating assessment of interaction severity.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics with strong D2 antagonism: additive extrapyramidal effects.
  • CYP450 inhibitors (e.g., ketoconazole): increase levosulpiride plasma levels.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: may worsen constipation.
  • CNS depressants (e.g., benzodiazepines): enhanced sedation.
  • SSRIs: potential for serotonin syndrome (rare).

Frequently Asked Questions

Levosulpiride Eg is prescribed for schizophrenia, depressive and anxiety disorders, functional dyspepsia, and gastroparesis. It targets dopaminergic pathways to manage psychotic symptoms and improve gastrointestinal motility.

Levosulpiride acts as a selective dopamine D2 receptor antagonist. In the brain, this reduces dopaminergic overactivity, alleviating psychotic symptoms. In the gut, D2 blockade enhances cholinergic activity, stimulating gastric emptying and providing prokinetic benefits.

The appropriate dose of levosulpiride is determined by the prescribing clinician based on the specific indication, patient characteristics, and therapeutic response. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for levosulpiride in pregnancy and lactation are limited. It is generally advised to avoid use unless the potential benefit justifies the potential risk to the fetus or infant, and decisions should be made in consultation with a healthcare professional.

To request Levosulpiride Eg, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Levosulpiride differs from many antipsychotics by combining dopamine D2 antagonism with prokinetic activity, making it useful for both psychiatric and gastrointestinal indications. Compared with typical antipsychotics, it may have a lower propensity for certain metabolic side effects but still carries risk of extrapyramidal symptoms.

Levosulpiride Eg should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability.

Levosulpiride Eg is administered orally, typically as a tablet taken with or without food as directed by the prescriber. The exact timing and frequency depend on the individual treatment plan established by the healthcare provider.

Serious risks include extrapyramidal symptoms such as tardive dyskinesia, neuroleptic malignant syndrome, severe hyperprolactinemia, and rare cardiac arrhythmias. Patients should be monitored for these events, and any concerning symptoms should prompt immediate medical evaluation.

Levosulpiride is contraindicated in patients with known hypersensitivity to the drug or other benzamide antipsychotics. Caution is advised for individuals with severe renal impairment, uncontrolled cardiac disease, or those taking medications that may cause dangerous interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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