Product image of Levothyroxine Crescent Pharma (Anhydrous Levothyroxine Sodium) supplied by GNH India

Levothyroxine Crescent Pharma

Active Ingredient:
Anhydrous Levothyroxine Sodium
Origin:
EU

Levothyroxine Crescent Pharma (Anhydrous Levothyroxine Sodium)

Levothyroxine, the active ingredient in Levothyroxine Crescent Pharma, is a thyroid hormone presented as an oral tablet for oral use. It replaces deficient endogenous thyroid hormone and is used to treat hypothyroidism, support patients after thyroidectomy, and manage goiter.
GNH India supplies Levothyroxine Crescent Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Crescent Pharma International Limited

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Indications & Clinical Uses

Levothyroxine acts on the thyroid hormone pathway to restore normal metabolic function.

  • Hypothyroidism: normalizes thyroid hormone levels and alleviates symptoms such as fatigue and weight gain.
  • Post‑thyroidectomy hormone replacement: provides the missing thyroxine after surgical removal of the thyroid gland.
  • Goiter: reduces gland enlargement by supplying adequate hormone and suppressing TSH stimulation.

How It Works

  • Levothyroxine is a synthetic form of the endogenous hormone thyroxine (T4). After oral absorption, it enters the bloodstream, binds nuclear thyroid hormone receptors, and modulates gene transcription that controls basal metabolic rate, protein synthesis, and growth. By restoring circulating T4, it normalizes feedback to the pituitary, reducing thyroid‑stimulating hormone (TSH) secretion and stabilizing thyroid function.

Side Effects

Levothyroxine may cause a range of adverse reactions, which are generally categorized by frequency.

Common Side Effects

  • Headache
  • Nervousness
  • Insomnia
  • Weight loss
  • Palpitations
  • Heat intolerance

Serious or Rare Side Effects

  • Cardiac arrhythmia
  • Angina or myocardial infarction
  • Severe bone loss (osteoporosis)
  • Allergic reaction (rash, angioedema)
  • Thyrotoxic crisis
  • Severe hyperglycemia

Precautions & Warnings

When prescribing Levothyroxine, clinicians should consider several safety measures.

  • Dose adjustment: individualize based on serial thyroid function tests.
  • Cardiovascular disease: monitor for tachycardia, angina, or arrhythmias.
  • Elderly patients: initiate therapy with a lower dose and titrate cautiously.
  • Pregnancy and lactation: use only if clearly indicated after risk‑benefit assessment.
  • Drug interactions: review all concomitant medications for potential absorption or metabolic effects.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levothyroxine can interact with several medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Antithyroid drugs (e.g., propylthiouracil, methimazole): antagonize levothyroxine effect.
  • Lithium: may impair thyroid hormone release.
  • Amiodarone: can alter thyroid hormone levels dramatically.
  • Estrogen‑containing oral contraceptives: increase levothyroxine dose requirement.
  • Calcium or iron supplements: reduce levothyroxine absorption when taken simultaneously.

Moderate Interactions (Monitor Closely)

  • Cholestyramine: may decrease levothyroxine absorption.
  • Rifampin: may increase levothyroxine metabolism.
  • Phenytoin and carbamazepine: may lower serum levothyroxine levels.
  • Warfarin: levothyroxine can enhance anticoagulant effect.
  • Beta‑blockers: may mask symptoms of excess thyroid hormone.

Frequently Asked Questions

Levothyroxine Crescent Pharma is prescribed to replace deficient thyroid hormone in patients with hypothyroidism, to provide hormone support after total or partial thyroidectomy, and to manage goiter by normalizing thyroid‑stimulating hormone levels. It helps restore normal metabolism and alleviates related symptoms.

Levothyroxine is a synthetic form of thyroxine (T4). After oral absorption, it binds to nuclear thyroid hormone receptors, influencing gene transcription that regulates basal metabolic rate, protein synthesis, and growth. By increasing circulating T4, it reduces pituitary TSH secretion, thereby stabilizing thyroid function.

The appropriate dose of Levothyroxine Crescent Pharma is individualized by the prescribing clinician based on the patient’s age, weight, severity of hypothyroidism, cardiac status, and laboratory thyroid function tests. Patients should follow the exact dosing instructions provided by their healthcare professional.

Levothyroxine is classified as a pregnancy‑category drug only when clearly needed. Adequate maternal thyroid hormone is essential for fetal development, so the medication may be continued under medical supervision. Breastfeeding mothers should also discuss continuation with their physician, as levothyroxine is excreted in small amounts in milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Levothyroxine provides synthetic T4, the same hormone produced by a healthy thyroid gland, and is the standard of care for most hypothyroid patients. Alternatives such as liothyronine (T3) or combination T4/T3 products may be used in specific cases, but levothyroxine offers a predictable pharmacokinetic profile and is widely studied.

Store the tablets at ambient temperature, preferably below 25 °C, in the original blister pack or container. Protect them from moisture, excessive heat, and direct sunlight. Do not store in the bathroom or near a kitchen sink to maintain product stability.

Levothyroxine Crescent Pharma is taken orally, usually on an empty stomach, at least 30‑60 minutes before breakfast. Swallow the tablet whole with a full glass of water; do not crush or chew. Consistency in timing and food intake helps maintain stable blood levels.

Serious risks include cardiac arrhythmias, angina, myocardial infarction, severe bone loss (osteoporosis), allergic reactions such as rash or angioedema, and thyrotoxic crisis. Patients should promptly report chest pain, rapid heartbeat, severe bone pain, or signs of an allergic reaction to their healthcare provider.

Levothyroxine Crescent Pharma should be avoided in patients with untreated adrenal insufficiency, uncorrected thyrotoxicosis, or known hypersensitivity to levothyroxine or any excipients. Caution is also advised for individuals with recent myocardial infarction, uncontrolled cardiac disease, or severe osteoporosis, and use should be guided by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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