Product image of Levotiroxina Sódica Ratiopharm (Levothyroxine Sodium) supplied by GNH India

Levotiroxina Sódica Ratiopharm

Active Ingredient:
Levothyroxine Sodium
Origin:
EU

Levotiroxina Sódica Ratiopharm (Levothyroxine Sodium)

Levothyroxine sodium, the active ingredient in Levotiroxina Sódica, is a thyroid hormone presented as an oral tablet for oral use. It replaces deficient endogenous thyroid hormone, treating hypothyroidism and supporting patients after thyroidectomy or with goiter, thereby restoring normal metabolic activity.

GNH India supplies Levotiroxina Sódica as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards, meeting stringent regulatory requirements, and providing reliable global distribution.

Manufacturer / TM Owner

Ratiopharm-Comercio E Industria De Produtos Farmaceuticos Lda

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Indications & Clinical Uses

Levothyroxine sodium is used to treat conditions related to thyroid hormone deficiency, acting within the endocrine system to restore normal hormone levels.

  • Hypothyroidism: restores normal thyroid hormone levels, alleviating symptoms such as fatigue, weight gain, and cold intolerance.
  • Post‑thyroidectomy hormone replacement: provides necessary thyroxine after surgical removal of the thyroid gland.
  • Goiter: reduces thyroid gland enlargement by normalizing hormone feedback mechanisms.

How It Works

  • Levothyroxine sodium is a synthetic form of thyroxine (T4) that binds to nuclear thyroid hormone receptors, regulating gene transcription and metabolic processes. By supplementing deficient endogenous hormone, it restores normal basal metabolic rate, protein synthesis, and thermogenesis, thereby normalizing physiological functions that depend on thyroid hormone activity.

Side Effects

Levothyroxine sodium may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: mild to moderate pain in the head.
  • Insomnia: difficulty falling or staying asleep.
  • Palpitations: sensation of rapid or irregular heartbeat.
  • Heat intolerance: increased sensitivity to warm temperatures.

Serious or Rare Side Effects

  • Cardiac arrhythmia: abnormal heart rhythm that may be life‑threatening.
  • Angina pectoris: chest pain due to reduced blood flow to the heart.
  • Myocardial infarction: heart attack occurring in susceptible individuals.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.

Precautions & Warnings

When prescribing levothyroxine sodium, several safety considerations are recommended.

  • Dose adjustment in elderly: start with a lower dose and titrate cautiously.
  • Monitor thyroid function tests: regular TSH and free T4 measurements are required.
  • Cardiovascular disease caution: assess heart condition before initiating therapy.
  • Adrenal insufficiency risk: ensure adequate glucocorticoid coverage before increasing dose.
  • Pregnancy and lactation: evaluate risk‑benefit ratio with a healthcare provider.
  • Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and light.

Avoid Interactions

Levothyroxine sodium can interact with several medicines, affecting its absorption or activity.

Major Interactions (Avoid)

  • Calcium supplements: reduce levothyroxine absorption; separate dosing by at least 4 hours.
  • Iron preparations: interfere with absorption; separate dosing by at least 4 hours.
  • Sucralfate: binds levothyroxine in the gut, decreasing effectiveness.
  • Cholesterol‑binding resins (e.g., cholestyramine): markedly decrease absorption.

Moderate Interactions (Monitor Closely)

  • Amiodarone: may alter thyroid hormone levels; monitor thyroid function.
  • Warfarin: levothyroxine can enhance anticoagulant effect; check INR regularly.
  • Estrogen therapy: may increase levothyroxine requirement; adjust dose as needed.

Frequently Asked Questions

Levotiroxina Sódica contains levothyroxine sodium, which is prescribed to replace deficient thyroid hormone in patients with hypothyroidism, after thyroidectomy, or with goiter. By normalising hormone levels, it helps restore metabolic balance and alleviates related symptoms.

Levothyroxine sodium is a synthetic form of the natural hormone thyroxine (T4). After oral absorption, it enters cells and binds to nuclear thyroid hormone receptors, influencing gene transcription that controls metabolism, growth, and development, thereby compensating for the body’s lack of endogenous hormone.

The appropriate dose of Levotiroxina Sódica is determined individually by a qualified prescriber based on factors such as age, weight, severity of hormone deficiency, and laboratory thyroid function results. Patients should follow the specific dosing instructions provided by their healthcare professional.

Safety in pregnancy and lactation depends on the clinical situation. Levothyroxine is often continued during pregnancy to maintain maternal thyroid levels, but the decision must be made by a physician who weighs potential benefits against any risks. Breastfeeding mothers should also consult their doctor.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Levotiroxina Sódica is a generic levothyroxine formulation equivalent in potency to other branded or generic T4 products. Differences may lie in excipients, tablet size, or manufacturing standards, but clinical efficacy and safety are comparable when the same daily dose is administered.

Store the tablets at ambient temperature, preferably below 25 °C, in the original blister pack or container. Protect them from excess moisture, heat, and direct sunlight to maintain potency throughout the shelf life.

Levotiroxina Sódica is taken orally, usually on an empty stomach, at least 30 minutes before breakfast. The tablet should be swallowed whole with a full glass of water; it should not be crushed, chewed, or divided unless specifically instructed by a healthcare provider.

Serious risks include cardiac arrhythmias, angina, myocardial infarction, and severe allergic reactions such as anaphylaxis. Patients with pre‑existing heart disease, adrenal insufficiency, or a history of hypersensitivity should be monitored closely and report any alarming symptoms promptly.

Levotiroxina Sódica should be avoided in individuals with known hypersensitivity to levothyroxine or any tablet excipients. It is also contraindicated in patients with untreated adrenal insufficiency or acute myocardial infarction until the underlying condition is stabilized.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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